Results 91 to 100 of about 51,615 (305)

TimeFlow 2: An Unsupervised Cell Lineage Detection Method for Flow Cytometry Data

Cytometry Part A, EarlyView.
TimeFlow 2 is a new method for cell lineage inference in flow cytometry data. It constructs cell state paths along pseudotime and aggregates them into biologically informative groups. It allows tracking of cytometry markers within each automatically inferred lineage.
Margarita Liarou, Thomas Matthes, Stéphane Marchand‐Maillet   +2 more
wiley   +1 more source

Hematologic responses to deferasirox therapy in transfusion-dependent patients with myelodysplastic syndromes

Haematologica, 2012
Background Reductions in transfusion requirements/improvements in hematologic parameters have been associated with iron chelation therapy in transfusion-dependent patients, including those with myelodysplastic syndromes; data on these reductions ...
Norbert Gattermann, Carlo Finelli, Matteo Della Porta, Pierre Fenaux, Michael Stadler, Agnes Guerci-Bresler, Mathias Schmid, Kerry Taylor, Dominique Vassilieff, Dany Habr, Andrea Marcellari, Bernard Roubert, Christian Rose   +12 more
doaj   +1 more source

TP53 and MDM2 single nucleotide polymorphisms influence survival in non-del(5q) myelodysplastic syndromes [PDF]

, 2015
:P53 is a key regulator of many cellular processes and is negatively regulated by the human homolog of murine double minute-2 (MDM2) E3 ubiquitin ligase.
Basiorka, Ashley A., Cluzeau, Thomas, Epling-Burnette, P. K., Irvine, Brittany A., Ling, Zhang, List, Alan F., Maciejewski, Jaroslaw, Mallo, Mar, McGraw, Kathy L., Rollison, Dana E., Sallman, David A., Sokol, Lubomir, Solé, Francesc   +12 more
core   +3 more sources

Clinical Images: Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome presenting as aseptic pustular dermatosis: A rare clinical manifestation

Arthritis &Rheumatology, EarlyView.
Peter Chen, Héloïse Briançon, Deborah Eshagh, Tali‐Anne Szwebel, Benjamin Terrier, Pierre Sohier, Rudy Birsen   +6 more
wiley   +1 more source

Efficacy, safety, and relapse outcomes of MAPK inhibitors in pediatric Langerhans cell histiocytosis: A real‐world study

International Journal of Cancer, EarlyView.
What's new? Mitogen‐activated protein kinase (MAPK) inhibitors are promising treatments for pediatric Langerhans cell histiocytosis (LCH), a rare heterogeneous neoplasm that often affects multiple organ systems. Which MAPK inhibitors are most effective against LCH remains uncertain.
Xue Tang, Jing‐jing Sun, Zhi Wan, Xiao‐yu Jing, Xia Guo, Ju Gao   +5 more
wiley   +1 more source

The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

Haematologica, 2012
Background Patients with paroxysmal nocturnal hemoglobinuria harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation.
Jeffrey J. Pu, Rong Hu, Galina L. Mukhina, Hetty E. Carraway, Michael A. McDevitt, Robert A. Brodsky   +5 more
doaj   +1 more source

Comparison of I-FISH and G-banding for the detection of chromosomal abnormalities during the evolution of myelodysplastic syndrome [PDF]

, 2009
Myelodysplastic syndrome (MDS) patients with a normal karyotype constitute a heterogeneous group from a biological standpoint and their outcome is often unpredictable. Interphase fluorescence in situ hybridization (I-FISH) studies could increase the rate
Chauffaille, Maria de Lourdes Lopes Ferrari, Pinheiro, R.f.   +1 more
core   +2 more sources

Acute severe cholestatic hepatitis and lymphopenia characterize pediatric hepatitis‐associated aplastic anemia

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Hepatitis‐associated aplastic anemia (HAAA) is described as acute severe hepatitis of unknown origin followed by bone marrow failure (BMF). We aimed to provide a comprehensive picture of pediatric HAAA. Methods Two‐center retrospective analysis was performed using data from children diagnosed with acquired BMF, including severe ...
Daniel Tegtmeyer, Sofia Tsaka, Kai Lehmberg, Michaela Höfs, Jan Beime, Andrea Briem‐Richter, Jun Oh, Elke Lainka, Sebastian Schulz‐Jürgensen   +8 more
wiley   +1 more source

Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients

Haematologica, 2016
The clinical and histopathological distinctions between inherited versus acquired bone marrow failure and myelodysplastic syndromes are challenging.
Siobán B. Keel, Angela Scott, Marilyn Sanchez-Bonilla, Phoenix A. Ho, Suleyman Gulsuner, Colin C. Pritchard, Janis L. Abkowitz, Mary-Claire King, Tom Walsh, Akiko Shimamura   +9 more
doaj   +1 more source

CLINICAL APPLICABILITY OF PROPOSED ALGORITHM FOR IDENTIFYING INDIVIDUALS AT RISK FOR HEREDITARY HEMATOLOGIC MALIGNANCIES [PDF]

, 2017
Over the past decade, more than 12 genes have been identified to cause hereditary predispositions to hematologic malignancies. These syndromes are characterized by an increased risk to develop myelodysplastic syndrome (MDS), acute myeloid leukemia (AML),
Clifford, Maggie
core   +1 more source