Results 111 to 120 of about 42,337 (292)

Bestatin Treatment of Myelodysplastic Syndromes (MDS) and the Effects of Bestatin on Hematopoiesis in MDS [PDF]

, 1990
Y Uzuka, Yoshiko Saito
openalex   +1 more source

The importance of systemic inflammatory response measurements as pretransplant risk factors for outcome after allogeneic haematopoietic cell transplantation

British Journal of Haematology, EarlyView.
In oncological patients SIR measures like the mGPS have great impact on prognosis at starting therapy. We recorded at admission for allo‐HCT the mGPS in 2201 patients: score 0 CRP/sALB normal; score 1 CRP >10mg/dl; score 2 CRP >10mg/dl + sALB <35g/L. Multivariate analysis revealed a significant impact with a low GPS score for OS: mGPS 1 vs.
Hartmut Bertz, Jörg Sahlmann, Donald C. McMillan, Claudia Wehr, Jesus Duque‐Afonso, Kristina Maas‐Bauer, Ralph Wäsch, Julia Nikolaychuk, Christine Greil, Jann Arends, Jürgen Finke, Robert Zeiser   +11 more
wiley   +1 more source

Pharmacologic doses of recombinant human erythropoietin in the treatment of myelodysplastic syndromes [see comments] [PDF]

, 1991
R S Stein, RI Abels, SB Krantz
openalex   +1 more source

A phase 1, first‐in‐human, dose‐escalation study of JNJ‐74856665 (dihydroorotate dehydrogenase inhibitor) alone or in combination in patients with AML or MDS

British Journal of Haematology, EarlyView.
Emma Searle, Thomas Cluzeau, Jenny O'Nions, Christian Recher, Emmanuel Gyan, Daniel Morillo, Jordi Esteve, Austin Kulasekararaj, Emmanuel Raffoux, Harriet S. Walter, Arnaud Pigneux, David Valcárcel, Nikki Daskalakis, Jacqueline Bussolari, E. Christine Pietsch, Scott Kuduk, Tammy Bush, Xiaochun Zhang, Ulrike Philippar, Adetokunbo Oluwasanjo, Kathryn Bradford, Jonathan Miller, Charlotte Van Bogaert, Martin Curtis, Shih‐Yu Chang, Christina Guttke, Stan Gaj, Rachel Pearson, Joseph Murphy, Wim van Dijck, Ana Alfonso Piérola   +30 more
wiley   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Patients’ needs in hematology: whose perspectives?

Haematologica, 2013
Sam Salek, Tatyana Ionova, Esther Oliva
doaj   +1 more source

The evaluation of low-dose cytarabine in the treatment of myelodysplastic syndromes: a phase-III intergroup study [PDF]

, 1993
K B Miller, K. Kyungmann, Francis S. Morrison, Jane N. Winter, John M. Bennett, Richard S. Neiman, David R. Head, Peter A. Cassileth, M J O'Connell   +8 more
openalex   +1 more source

TP‐0903 Suppresses Aurora A–PLK1 Signaling to Inhibit Proliferation of a Myelodysplastic Syndrome‐Derived Cell Line

Cancer Science, EarlyView.
TP‐0903 exerts the antitumor effects through diverse cell‐specific mechanisms, including apoptosis, ferroptosis, and cell cycle disruption. These insights underline the potential of TP‐0903 as a therapeutic agent for hematological malignancies and emphasize the need for further research to fully elucidate the molecular targets of TP‐0903 and optimize ...
Tomoko Kimura‐Hyoda, Mikuri Ryu, Ryosuke Yuta, Saori Fukumoto, Kentaro Hosokawa, Hisayuki Yao, Yoko Yasuda, Koichi Miura, Kaoru Tohyama, Fumio Arai, Takeshi Uchiumi   +10 more
wiley   +1 more source

Globin chain synthesis in myelodysplastic syndromes. [PDF]

, 1991
G. Chalevelakis, S Karaoulis, Athanasios Yalouris, T. Economopoulos, Nikolaos Tountas, S. Raptis   +5 more
openalex   +1 more source

Homoharringtonine Promotes FTO Degradation to Suppress LILRB4‐Mediated Immune Evasion in Acute Monocytic Leukaemia

Cell Proliferation, EarlyView.
Homoharringtonine (HHT) suppresses immune evasion in acute monocytic leukaemia (AML‐M5) by attenuating the FTO/m6A/LILRB4 axis, thereby enhancing CD8+ T cell cytotoxicity. ABSTRACT Acute monocytic leukaemia, a subtype of acute myeloid leukaemia (AML), is a highly aggressive malignancy characterised by a poor prognosis, primarily due to the ability of ...
Fangfang Huang, Xiang Luo, Mengyu Zhang, Le Jin, Wenxin Sun, Peihan Chen, Xiuli Hong, Chenyu Xu, Meizhi Jiang, Die Hu, Bin Zhang, Shengwei Hu, Chuanjiang Yang, Rui Gao, Jinzhang Zeng, Quanyi Lu, Qiang Luo, Jun Wu, Siming Chen   +18 more
wiley   +1 more source