Results 11 to 20 of about 27,004 (255)

PANoptosis in the pathogenesis of myelodysplastic syndromes. [PDF]

Mol Oncol
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Thalla R, Lamichhane J, Lewis C, Breslin P, Zhang J.   +4 more
europepmc   +2 more sources

The myelodysplastic syndromes. [PDF]

BMJ, 1987
The myelodysplastic syndromes constitute a fascinating model for monoclonal premalignant disorders. Haemopoiesis is 'dysplastic' with inefficient maturation of a slowly expanding or sometimes of a stable population, of blood cell precursors. About one third of the patients evolve into acute leukaemia, the result of either a progressive expansion of the
LAYTON, DM, MUFTI, GJ
openaire   +5 more sources

Myelodysplastic syndromes

HemaSphere, 2019
Johanna Ungerstedt, (Coordinating Author)
doaj   +3 more sources

Myelodysplastic Syndromes [PDF]

Acta Haematologica, 2009
The myelodysplastic syndromes (MDS) represent a group of syndromes having in common a defective production of one or more myeloid cell lines. They occur in patients which are more than 50 years old without any sex preponderance. The term MDS is replacing the obsolete and archaic term of’preleukemia’ and/ or ‘oligoblastic leukemia’.
C, Sultan, M, Imbert, H, Jouault, J Y, Scoazec   +3 more
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Myelodysplastic syndromes [PDF]

Seminars in Diagnostic Pathology, 2011
Myelodysplastic syndromes (MDS) are hematopoietic neoplasms characterized by an ineffective hematopoiesis associated with cytopenia(s), functional abnormalities of bone marrow lineages, morphologic dysplasia, and a progression to acute myeloid leukemia.
Jiehao, Zhou, Attilio, Orazi, Magdalena B, Czader   +2 more
openaire   +4 more sources

Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes

Haematologica, 2017
Flow cytometric analysis is a recommended tool in the diagnosis of myelodysplastic syndromes. Current flow cytometric approaches evaluate the (im)mature myelo-/monocytic lineage with a median sensitivity and specificity of ~71% and ~93%, respectively. We
Eline M.P. Cremers, Theresia M. Westers, Canan Alhan, Claudia Cali, Heleen A. Visser-Wisselaar, Dana A. Chitu, Vincent H.J. van der Velden, Jeroen G. te Marvelde, Saskia K. Klein, Petra Muus, Edo Vellenga, Georgina E. de Greef, Marie-Cecile C.J.C. Legdeur, Pierre W. Wijermans, Marian J.P.L. Stevens-Kroef, Pedro da Silva-Coelho, Joop H. Jansen, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht   +18 more
doaj   +1 more source

Multicentric study underlining the interest of adding CD5, CD7 and CD56 expression assessment to the flow cytometric Ogata score in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

Haematologica, 2015
Although numerous recent publications have demonstrated interest in multiparameter flow cytometry in the investigation of myelodysplastic disorders, it is perceived by many laboratory hematologists as difficult and expensive, requiring a high level of ...
Valérie Bardet, Orianne Wagner-Ballon, Julien Guy, Céline Morvan, Camille Debord, Franck Trimoreau, Emmanuel Benayoun, Nicolas Chapuis, Nicolas Freynet, Cédric Rossi, Stéphanie Mathis, Marie-Pierre Gourin, Andréa Toma, Marie C. Béné, Jean Feuillard, Estelle Guérin   +15 more
doaj   +1 more source

Marked upregulation of Survivin and Aurora-B kinase is associated with disease progression in the myelodysplastic syndromes

Haematologica, 2012
Background Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis. Survivin is a member of the inhibitor of apoptosis family and suppresses apoptosis.
Akira Yoshida, Kouichi Zokumasu, Yuji Wano, Takahiro Yamauchi, Shin Imamura, Kazutaka Takagi, Shinji Kishi, Yoshimasa Urasaki, Kaoru Tohyama, Takanori Ueda   +9 more
doaj   +1 more source

Extramedullary Hematopoiesis in Myelodysplastic Syndromes: A Systematic Literature Review

Hemato, 2022
Extramedullary hematopoiesis is rarely seen in patients with myelodysplastic syndromes, and its clinical characterizations are not well-defined.
Chen Wang, Yiyun Shi
doaj   +1 more source

Myelodysplastic syndrome with synchronous gastric cancer: when the symptoms suggest something else

Revista Brasileira de Hematologia e Hemoterapia, 2014
Although myelodysplastic syndromes have a clear definition in theory, the morphologic dysplasia associated with ineffective hematopoiesis may be subtle and difficult to recognize and can commonly be mimicked by systemic conditions, such as infections ...
Paula de Melo Campos, Fabiola Traina, Irene Lorand-Metze, Sara Teresinha Olalla Saad   +3 more
doaj   +1 more source