Results 221 to 230 of about 52,382 (294)

Advancing drug development in myelodysplastic syndromes. [PDF]

Blood Adv
Mina A, McGraw KL, Cunningham L, Kim N, Jen EY, Calvo KR, Ehrlich LA, Aplan PD, Garcia-Manero G, Foran JM, Garcia JS, Zeidan AM, DeZern AE, Komrokji R, Sekeres MA, Scott B, Buckstein R, Tinsley-Vance S, Verma A, Verma A, Wroblewski T, Pavletic S, Norsworthy K.   +22 more
europepmc   +1 more source

Loss of Chromosome Y Associates With Altered Immune Cell Trajectories and X‐Inactivation Features

Aging Cell, Volume 25, Issue 5, May 2026.
Loss of chromosome Y in male leukocytes exhibits cell type‐specific effects on immune cell phenotypes and transcriptional profiles along differentiation trajectories. LOY is associated with profibrotic monocyte signatures and aberrant X‐inactivation gene expression, highlighting links to immune dysfunction and age‐related diseases in men.
Ahmed Dawoud, Luke Green, Owen Rackham
wiley   +1 more source

Health-related quality of life of patients with acute myeloid leukemia and myelodysplastic syndromes/neoplasms treated with decitabine: a systematic literature review. [PDF]

Ann Hematol
Cannella L, Venditti A, Palmieri R, Puglia S, Luppi M, Breccia M, Efficace F.   +6 more
europepmc   +1 more source

Familial Adenomatous Polyposis—Risk of Cancer, Cancer Prevention, and Long‐Term Consequences: Learnings from Five Decades with the Danish Polyposis Register

APMIS, Volume 134, Issue 5, May 2026.
ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley   +1 more source

Development of Machine-Assisted, Human-Centred Bone Marrow Cell Classification: Feasibility Analysis in Patients With Myelodysplastic Syndromes. [PDF]

EJHaem
Ogata K, Mochimaru Y, Saft L, Sijm G, Badaoui B, Alhan C, Almire C, Kato Y, Sakamoto D, Chiba N, Murata N, Kasai N, Sei K, Kawahara N, Ogata M, Chapuis N, Wagner-Ballon O, van de Loosdrecht A, Yamamoto Y.   +18 more
europepmc   +1 more source

Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan, Vishnu Sharma, Venkatesh Atul Bhattaram, Xiaolei Pan, Justin Earp, Yun Wang, Jiang Liu, Hao Zhu   +7 more
wiley   +1 more source

Host Transcriptomics and Culture‐Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit

European Journal of Haematology, Volume 116, Issue 5, Page 625-634, May 2026.
ABSTRACT Background Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non‐infectious fever. T2 magnetic resonance (T2MR) is a culture‐independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is a host response assay ...
Anna Maria Peri, Andrea S. Henden, Ricky Nelles, Mark D. Chatfield, Patrick N. A. Harris, Glen Kennedy, David L. Paterson   +6 more
wiley   +1 more source

Improvement in survival of patients with higher risk but not lower risk myelodysplastic syndromes over 20 years: A retrospective study from Nagasaki, Japan. [PDF]

Br J Haematol
Furumoto T, Ando K, Toriyama E, Hata T, Sakamoto H, Chiwata M, Kitanosono H, Nakashima J, Kato T, Taguchi M, Horai M, Itonaga H, Sato S, Sawayama Y, Imanishi D, Imaizumi Y, Jo T, Yoshida S, Moriuchi Y, Miyazaki Y.   +19 more
europepmc   +1 more source

LDLRAD4 is a potential diagnostic and prognostic biomarker correlated with immune infiltration in myelodysplastic syndromes. [PDF]

Front Genet
Xu M, Wu S, Zhang K, Nie L, Li Q, Zhong J, Zhang Y, He H.   +7 more
europepmc   +1 more source

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer [PDF]

, 2019
Bresnick, Emery H, Cao, Miao, Choi, Kyunghee, Hofmann, Inga, Johnson, Kirby D, Keles, Sunduz, Liu, Peng, Mahta, Charu, Soukup, Alexandra A, Wu, Jun, Zhang, Jing, Zheng, Ye, Zhou, Yun   +12 more
core   +1 more source