Results 131 to 140 of about 60,513 (321)

Idiopathic splanchnic vein thrombosis: is it really idiopathic?

Haematologica, 2022
Giovanni Barosi
doaj   +1 more source

BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms. [PDF]

, 2013
Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of mixed lineage leukemia (MLL) fusion protein-driven leukemias.
Bannister, AJ, Barbieri, I, Calero-Nieto, FJ, Cannizzaro, E, Dawson, MA, Godfrey, A, Gottgens, B, Green, AR, Huntly, B, Kouzarides, T, Li, J, Nangalia, J, Prinjha, RK, Rioja, I, Robson, S, Wiese, M, Wyspiańska, BS   +16 more
core   +1 more source

Triple A Plus (AAA +) Survival Prediction Model for Essential Thrombocythemia: Analysis Involving 7308 Patients

American Journal of Hematology, Volume 100, Issue 11, Page 2017-2027, November 2025.
A new risk model for essential thrombocythemia that is based on complete blood cell count‐derived parameters and host‐related factors. ABSTRACT Survival prediction models in essential thrombocythemia (ET) include the International Prognostic Scoring System (IPSET) and the more recently introduced triple‐A (AAA) prognostic score.
Ayalew Tefferi, Giuseppe G. Loscocco, Lior Rokach, Tamar Tadmor, Priyansh Faldu, Guy Melamed, Hilel Alapi, Maymona Abdelmagid, Rania M. Abdelaziz, Muhammad Yousuf, Merry Nakhleh, Animesh Pardanani, Kebede H. Begna, Mirnal M. Patnaik, Natasha Szuber, Alessandra Carobbio, Tiziano Barbui, Kaaren K. Reichard, Rong He, Paola Guglielmelli, Naseema Gangat, Alessandro M. Vannucchi   +21 more
wiley   +1 more source

Longitudinal In Vivo 3T MRI of Naturally Occurring Early Osteochondrosis Lesions in the Piglet Humeral Epiphyseal Cartilage and Growth Plate

Journal of Orthopaedic Research, Volume 43, Issue 11, Page 1934-1941, November 2025.
ABSTRACT Osteochondrosis/osteochondritis dissecans (OC/OCD) is a developmental orthopedic disease primarily affecting the knee, ankle, and elbow joints of children and multiple animal species. Subclinical lesions of OC/OCD have been described, but most can be visualized only histologically in cadaveric specimens.
Alexandra R. Armstrong, Erick O. Buko, Casey P. Johnson, Ferenc Tóth   +3 more
wiley   +1 more source

Myelofibrosis [PDF]

Proceedings of the Royal Society of Medicine, 1952
R B, FRANKS, J S, RICHARDSON
openaire   +2 more sources

Increased angiogenesis in primary myelofibrosis: latent transforming growth factor-β as a possible angiogenic factor

Revista Brasileira de Hematologia e Hemoterapia, 2014
Objective: The aim of this work was to demonstrate a possible relationship between anti-latency-associated peptide human latent transforming growth factor beta 1 (latent TGF-β1) expression in megakaryocytes and microvascular density in bone marrow ...
Cesar Cilento Ponce, Maria de Lourdes Lopes Ferrari Chauffaille, Silvia Saiuli Miki Ihara, Maria Regina Regis Silva   +3 more
doaj   +1 more source

Systemic mastocytosis with associated myeloproliferative disease and precursor B lymphoblastic leukaemia with t(13;13)(q12;q22) involving FLT3. [PDF]

, 2008
Systemic mastocytoses represent neoplastic proliferations of mast cells. In about 20% of cases systemic mastocytoses are accompanied by clonal haematopoietic non-mast cell-lineage disorders, most commonly myeloid neoplasms.
Dirnhofer, S., Horny, H.-P., Jotterand, M., Muhlematter, D., Sotlar, Karl, Theocharides, A., Tzankov, A., Went, P.   +7 more
core   +1 more source

CALR Type 1‐Like Mutations Increase Endoplasmic Reticulum Free Ca2+ and Induce ERK1/2 Activation Independent of Thrombopoietin Receptor Activation

Cell Biology International, Volume 49, Issue 10, Page 1262-1273, October 2025.
ABSTRACT Calreticulin is a multifunctional protein found in the endoplasmic reticulum lumen that is important for calcium homeostasis and glycoprotein folding. Mutations in exon 9 of the CALR gene are the second most common genetic cause of myeloproliferative neoplasms.
Mifra Faiz, Caitlin Dunstan‐Harrison, Elizabeth C. Ledgerwood   +2 more
wiley   +1 more source

Long-term findings from COMFORT-II, a phase 3 study of ruxolitinib vs best available therapy for myelofibrosis

Leukemia, 2016
Ruxolitinib is a Janus kinase (JAK) (JAK1/JAK2) inhibitor that has demonstrated superiority over placebo and best available therapy (BAT) in the Controlled Myelofibrosis Study with Oral JAK Inhibitor Treatment (COMFORT) studies.
C. Harrison, A. Vannucchi, J. Kiladjian, H. Al-Ali, H. Gisslinger, L. Knoops, F. Cervantes, Mark M. Jones, K. Sun, M. Mcquitty, V. Stalbovskaya, Prashanth Gopalakrishna, T. Barbui   +12 more
semanticscholar   +1 more source

Management of Gaucher Disease Type 1 in a Resource‐Limited Setting: A Pediatric Case Study

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT This case report depicts the management of an 8‐year‐old male with Gaucher Disease Type 1, manifesting as massive splenomegaly, anemia, and skeletal involvement in a resource‐constrained environment. Treated with splenectomy due to the absence of enzyme replacement therapy, it underscores the necessity for enhanced therapeutic access and ...
Bipesh Kumar Shah, Diwakar Koirala, Bivek Mishra, Ramesh Sapkota, Manjil Basnet   +4 more
wiley   +1 more source