Results 151 to 160 of about 33,638 (296)

Multiple‐Dose Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Subcutaneous Rusfertide, a Hepcidin Mimetic, in Healthy Subjects

open access: yesClinical Pharmacology in Drug Development, Volume 14, Issue 4, Page 311-323, April 2025.
Abstract Rusfertide, a peptide hepcidin mimetic, has shown efficacy in polycythemia vera. This trial investigated the multiple‐dose pharmacokinetics, pharmacodynamics, and safety of once‐weekly rusfertide 60 mg for 5 weeks in healthy subjects. Subjects were randomized to subcutaneous injection in the abdomen, upper arm, or thigh. Eighteen subjects were
Nishit B. Modi   +2 more
wiley   +1 more source

Two Cases of Myelofibrosis

open access: bronze, 1971
Yuruko OKAMOTO   +3 more
openalex   +2 more sources

Reticulin‐Free Quantitation of Bone Marrow Fibrosis in MPNs: Utility and Applications

open access: yeseJHaem, Volume 6, Issue 2, April 2025.
ABSTRACT Background Automated quantitation of marrow fibrosis promises to improve fibrosis assessment in myeloproliferative neoplasms (MPNs). However, analysis of reticulin‐stained images is complicated by technical challenges within laboratories and variability between institutions.
Hosuk Ryou   +9 more
wiley   +1 more source

Real World Management of Cytopenias and Infections in Patients With Myelofibrosis Treated With Ruxolitinib

open access: yeseJHaem, Volume 6, Issue 2, April 2025.
ABSTRACT Introduction Ruxolitinib was the first JAK2 inhibitor approved for the treatment of primary and secondary myelofibrosis. It is currently used worldwide as first‐line therapy for advanced disease (intermediate‐2 and high‐risk) and is effective in polycythaemia vera (PV) and essential thrombocythaemia (ET), but not funded for this indication in ...
Liesl A. Butler   +3 more
wiley   +1 more source

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