Results 81 to 90 of about 88,666 (249)

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
A Quintas-Cardama, A Quintas-Cardama, A Quintas-Cardama, AJ Tipping, AJ Tipping, B Zhang, C Akgul, C Bellodi, G Gurel, H de Lavallade, H Konig, HG Jorgensen, HM Kantarjian, J Kuroda, KJ Aichberger, L Legros, M Copland, M Copland, NB Heaney, R Chen, R Tang, RG Powell, RM Stone, S Chu, SM Graham, SV Sharma, T Kobayashi, Y Chen   +27 more
core   +1 more source

Polypept(o)ide‐Based Core–Shell Bottlebrush Polymers: A Versatile Platform for Drug Encapsulation

Macromolecular Bioscience, Volume 25, Issue 7, July 2025.
This study developed polypept(o)ide‐based core–shell brushes (CSBs) with tunable sizes (Rh: 17–70 nm) for hydrophobic drug delivery. CSBs achieved 10% dasatinib loading through π–π interactions, enabling sustained release over 72 h. Notably, CSB‐dasatinib complexes showed comparable cell viability reduction to the free drug in U‐87 MG cells ...
Bonan Zhao, Jingyuan Wei, Rüdiger Berger, Lin Jian, Kaloian Koynov, Heyang Zhang, Matthias Barz   +6 more
wiley   +1 more source

Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Reham Hassan Mekky, Mohammed E. Abo‐El Fetoh, Safaa A. Faheem, Abdullah F. Radwan, Mariam H. Fawzy, Aya M. Mustafa, Mohamed A. Said, Daniela Calina, Javad Sharifi‐Rad, William C. Cho   +9 more
wiley   +1 more source

Potential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells

AMB Express, 2018
The lipopeptide iturin from Bacillus subtilis has been found to have a potential inhibitory effect on breast cancer, alveolar adenocarcinoma, renal carcinoma, and colon adenocarcinoma. In this study, the potential of B.
Haobin Zhao, Lu Yan, Xiaoguang Xu, Chunmei Jiang, Junling Shi, Yawen Zhang, Li Liu, Shuzhen Lei, Dongyan Shao, Qingsheng Huang   +9 more
doaj   +1 more source

Modelling hematopoiesis mediated by growth factors with applications to periodic hematological diseases [PDF]

, 2006
Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors.
Adimy, Mostafa, Crauste, Fabien, Ruan, Shigui   +2 more
core   +5 more sources

The Current State of Palliative Care Research for Adolescents and Young Adults With Cancer: A Systematic Review and Meta‐Thematic Analysis of Empirical Literature

Psycho-Oncology, Volume 34, Issue 7, July 2025.
ABSTRACT Background Palliative care is critical to the wellness of cancer patients and survivors, but adolescents and young adults (AYAs) with cancer are confronted with the divide between pediatric and adult palliative care as well as pediatric and adult/medical oncology. Consequently, attention to palliative care for AYAs with cancer has just started,
Anao Zhang, Meiyan Chen, Rachel Brandon, Jennifer Currin‐McCulloch, Xingzhi Liu, Brennan Cheladyn, Betty Ferrell, Barbara Jones, Bradley Zebrack, Adam S. DuVall   +9 more
wiley   +1 more source

Treatment of acute myelogenous leukaemia [PDF]

Journal of Internal Medicine, 1997
The author presents a brief overview of current therapy in adults of various ages with acute myelogenous leukaemia, including remission induction and post‐remission treatment and the use of haematopoietic growth factors.
openaire   +4 more sources

TP53 ‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, Volume 100, Issue S4, Page 88-115, June 2025.
ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53 mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah, Daniel A. Arber, Devendra K. Hiwase   +2 more
wiley   +1 more source

The BCR-ABLT315I mutation compromises survival in chronic phase chronic myelogenous leukemia patients resistant to tyrosine kinase inhibitors, in a matched pair analysis

Haematologica, 2013
The BCR-ABL T315I mutation confers resistance to currently licensed tyrosine kinase inhibitors in chronic myelogenous leukemia. However, the impact of this mutation on survival in early stages of disease, in chronic phase, has never been detailed.
Franck E. Nicolini, Amr R. Ibrahim, Simona Soverini, Giovanni Martinelli, Martin C. Müller, Andreas Hochhaus, Inge H. Dufva, Dong-Wook Kim, Jorge Cortes, Michael J. Mauro, Charles Chuah, Hélène Labussière, Stéphane Morisset, Catherine Roche-Lestienne, Eric Lippert, Sandrine Hayette, Senaka Peter, Wei Zhou, Véronique Maguer-Satta, Mauricette Michallet, John Goldman, Jane F. Apperley, François-Xavier Mahon, David Marin, Gabriel Etienne   +24 more
doaj   +1 more source

A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling [PDF]

, 2018
Trib2 pseudokinase is involved in the etiology of a number of cancers including leukaemia, melanoma, ovarian, lung and liver cancer. Both high and low Trib2 expression levels correlate with different types of cancer.
Carmody, Ruaidhri J., Chaudhury, Shahzya, Keeshan, Karen, Magee, Aoife, Salomé, Mara, Sarrou, Evgenia, Yalla, Krishna   +6 more
core   +2 more sources