Results 91 to 100 of about 919,731 (432)
Splenectomy in myeloid metaplasia [PDF]
Blood, 1979 Abstract Between 1960 and 1977, 50 patients with agnogenic myeloid metaplasia were splenectomized. Twenty-five of 26 patients with painful splenomegaly, 4 of 9 patients with refractory hemolytic anemia, 4 of 10 patients with refractory thrombocytopenia, and 4 of 4 patients with portal hypertension showed significant benefit from the ...
William H. ReMine, Murray N. Silverstein
openaire +4 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Extramedullary Acute Myeloid Leukemia Tumor Presenting in the Radial Nerve
Journal of the Belgian Society of Radiology, 2022 Teaching Point: Extramedullary acute myeloid leukemia tumor belongs to the differential diagnosis when a tumor develops in a patient with a history of leukemia, and magnetic resonance imaging is of diagnostic value by demonstrating iso-intensity and ...
Nico Hustings +2 more
doaj +1 more source
MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. [PDF]
, 2014 Low-grade systemic inflammation is often associated with metabolic syndrome, which plays a critical role in the development of the obesity-associated inflammatory diseases, including insulin resistance and atherosclerosis.
DeFranco, Anthony L +19 more
core +2 more sources
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
A model for the functional assessment of elderly with myeloid neoplasms
Revista Brasileira de Hematologia e Hemoterapia, 2015 Objective: Myeloid neoplasms are heterogeneous diseases that are more incident in the elderly. The goals of this study were to aggregate a geriatric approach to the patient assessment, to show the impact of gender, age, hemoglobin concentration and ...
Ana Lúcia Ippolito Carbonell +4 more
doaj +1 more source
VISTA: A Target to Manage the Innate Cytokine Storm
Frontiers in Immunology, 2021 In recent years, the success of immunotherapy targeting immunoregulatory receptors (immune checkpoints) in cancer have generated enthusiastic support to target these receptors in a wide range of other immune related diseases. While the overwhelming focus
Mohamed A. ElTanbouly +8 more
doaj +1 more source
Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
Cells, 2020 The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes.
Andrew M. K. Law +2 more
semanticscholar +1 more source
Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo. [PDF]
, 2015 Human cytomegalovirus (HCMV) causes significant morbidity in the immunocompromised host. Following primary infection, the virus establishes latent infection in progenitor cells of the myeloid lineage.
core +1 more source
Radiation-induced myeloid leukemia in murine models. [PDF]
, 2014 The use of radiation therapy is a cornerstone of modern cancer treatment. The number of patients that undergo radiation as a part of their therapy regimen is only increasing every year, but this does not come without cost.
Davoren, Michael +2 more
core +2 more sources