Results 101 to 110 of about 523,497 (297)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

FLT3 and IDH1/2 Inhibitors for Acute Myeloid Leukemia: Focused Clinical Narrative Review of Forthcoming Drugs from an Indian Context

Indian Journal of Medical and Paediatric Oncology
Therapeutic approaches for acute myeloid leukemia (AML) have witnessed minimal evolution in recent decades, primarily relying on advancements in supportive care and transplantation to drive improvements in overall survival rates.
Suvir Singh, Kunal Jain, Jagdeep Singh, Nitish Garg, Akriti Arora   +4 more
doaj   +1 more source

Molecular and cytogenetic abnormalities in acute myeloid leukemia: review and case studies [PDF]

Einstein (São Paulo), 2011
Objective: To study the frequency of mutations that maylead to a good or bad prognosis, as well as their relation withthe karyotype and immunophenotype in patients with acutemyeloid leukemia. Methods: Thirty samples of patients withacute myeloid leukemia
Elvira Deolinda Rodrigues Pereira Velloso, Carlos Henrique Ares Silveira da Motta, Juliana Braga Furtado, Nydia Strachman Bacal, Paulo Augusto Achucarro Silveira, Cynthia Bachir Moyses, Roberta Sitnik, João Renato Rebello Pinho   +7 more
doaj  

S154: IMATINIB-RESISTANT CLONES ISOLATED FROM A MODEL OF BLAST CRISIS OF CHRONIC MYELOID LEUKAEMIA DIFFER IN MUTATIONS IN BCR::ABL1 AND OTHER CANCER RELATED GENES AND IN THEIR SENSITIVITY TO BH3-MIMETICS

, 2022
A. Laznicka, N. Curik, Václava Polívková, Jitka Koblihova, P. Burda, Alexandra Dolníková, Eva Pokorná, Cyril Šálek, Hana Klamová, Dana Srbová, P. Klener, Kateřina Machová Poláková   +11 more
openalex   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

A novel ETV6::FGFR1 fusion gene in a myeloid/lymphoid neoplasm with FGFR1 rearrangement sensitive to specific FGFR1-2-3 inhibition

, 2023
Carlos Jiménez‐Vicente, Marta Garrote, Mònica López‐Guerra, Eva Villamón, Francesca Guijarro, Amanda Isabel Pérez‐Valencia, Alexandra Martinez-Roca, Olga Balaguer, Alberto Álvarez‐Larrán, Juan Carlos Hernández‐Boluda, Montserrat Rovira, Dolors Colomer, Marina Díaz‐Beyá, Marı́a Rozman, Jordi Esteve   +14 more
openalex   +2 more sources

CLINICAL FEATURES OF FLT3 MUTATIONS IN ACUTE MYELOID LEUKEMIA CASES AND THE ROLE OF FLT3 INHIBITORS IN THE TREATMENT OF ACUTE MYELOID LEUKEMIA: A SINGLE CENTER EXPERIENCE [PDF]

, 2022
İbrahim Halil Açar, Hüseyin Derya Dincyurek, Özge Sönmezler, Şule Menziletoğlu Yıldız, Atıl Bişgin, Birol Güvenç   +5 more
openalex   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Conditioning regimens in pediatric myeloid malignancies undergoing allogeneic HSCT: a comparative single-center study

Frontiers in Oncology
IntroductionOptimal conditioning regimen for pediatric myeloid malignancies is still subject for debate. This single-center retrospective study compares the efficacy and toxicity profiles of three conditioning strategies, myeloablative conditioning (MAC),
Andra D. Marcu, Andra D. Marcu, Cristina G. Jercan, Cristina G. Jercan, Ana M. Bica, Ana M. Bica, Andreea N. Serbanica, Andreea N. Serbanica, Letitia E. Radu, Letitia E. Radu, Irina Avramescu, Irina Avramescu, Anda Mocanu, Anda Mocanu, Oana O. Niculita, Oana O. Niculita, Delia C. Popa, Delia C. Popa, Cerasela Jardan, Cerasela Jardan, Mihaela Dragomir, Andrei Colita, Andrei Colita, Alina D. Tanase, Alina D. Tanase, Anca Colita, Anca Colita   +26 more
doaj   +1 more source

Survival of Patients with Acute Myeloid Leukemia Relapsing after Allogeneic Hematopoietic Cell Transplantation: A Center for International Blood and Marrow Transplant Research Study

, 2014
Nelli Bejanyan, Daniel J. Weisdorf, Brent R. Logan, Hai-Lin Wang, Steven M. Devine, Marcos de Lima, Donald Bunjes, Mei-Jie Zhang   +7 more
openalex   +1 more source