Results 181 to 190 of about 903,302 (304)

Limited but powerful toolbox: myeloid cells as critical immunomodulators in glioma progression. [PDF]

Signal Transduct Target Ther
Liu Y, Fang J, Sankowski R.
europepmc   +1 more source

Myeloid-derived suppressor cells coming of age

Nature Immunology, 2018
F. Veglia, Michela Perego, D. Gabrilovich   +2 more
semanticscholar   +1 more source

SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway

Advanced Science, EarlyView.
Structural maintenance of chromosome protein 4 (SMC4) has been implicated in prostate cancer metastasis. Knockdown of SMC4 in RM1‐LM cells significantly attenuates proliferation, migration, and lung metastasis in vivo. Furthermore, SMC4 interacts with GLUT1 (Slc2a1), thereby enhancing glycolysis, ATP production, and activation of the Rheb/mTOR pathway.
Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang   +9 more
wiley   +1 more source

AKI in chronic myeloid leukemia: remember lysozyme-induced nephropathy. [PDF]

J Bras Nefrol
Santos A, Marques N, Pestana R.
europepmc   +1 more source

Identification of CD38high Monocyte as a Candidate Diagnostic Biomarker and Therapeutic Target for Sepsis

Advanced Science, EarlyView.
This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua, Limin Kong, Li Fan, Yanan Bai, Yujun Zhou, Yanfang Zhang, Qingwei Zhao, Xiaoyang Lu, Hongyu Yang, Hangyang Li, Peili Ding, Yuyu Nan, Qinghua Ji, Ping Yang, Lu Li, Yijing Xin, Lijuan Zhao, Wei Yang, Wenqiao Yu, Saiping Jiang   +19 more
wiley   +1 more source

MAFB: a key regulator of myeloid commitment involved in hematological diseases. [PDF]

Cell Death Discov
Ventura AB, Loconte T, Negri A, Viggiano L, Fiermonte G, Ciavarella S, Guarini A, Volpe G.   +7 more
europepmc   +1 more source

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

Development of myeloid neoplasia associated with prolonged immune cell-associated hematotoxicity after CAR T-cell treatment of B-cell lymphoma: Should we surveille for pre-existing myeloid mutations? [PDF]

Hemasphere
Carlsten M, Lindfors Rossi EL, Jädersten M, Tesi B, Abd Own S, Sander B, Deneberg S, Ivinskiy A, Sonnevi K, Sjölund H, Enblad G, Wahlin B, Mielke S.   +12 more
europepmc   +1 more source

Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling

Advanced Science, EarlyView.
This research presents a novel strategy employing the VGM cocktail, which combines HES7 overexpression with HDAC inhibitor and GABA, to enhance platelet production from hematopoietic stem and progenitor cells by promoting megakaryocyte progenitor (MkP) generation.
Huicong Liu, Lingna Wang, Jiaqing Liu, Haitao Yuan, Kaiqing Zhang, Yun Qiu, Fangfang Zhu   +6 more
wiley   +1 more source

WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity. [PDF]

Nat Commun
Trzeciak AJ, Liu ZL, Gatie M, Krebs AS, Saitz Rojas W, O'Neal AJ, Baako AK, Wang Z, Nelson J, Miranda IC, Uddin J, Lipshutz A, Xie J, Huang CL, Saavedra PHV, Hadjantonakis AK, Overholtzer M, Glickman MS, Subramanya AR, Vierbuchen T, Etchegaray JI, Lucas CD, Parkhurst CN, Perry JSA.   +23 more
europepmc   +1 more source