Results 261 to 270 of about 1,067,293 (391)

Practical diagnostic approach to assess myeloid and precursor cell neoplasms on trephine bone marrow biopsies: reflection of middle European reality. [PDF]

J Hematop
Menter T, Tzankov A.
europepmc   +1 more source

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source

Somatic mutations in STAG2 are associated with separated megakaryocyte nuclear lobes in myelodysplastic syndromes. [PDF]

Blood Adv
Wong WJ, Zon RL, Gibson CJ, Ho C, Pozdnyakova O, Neuberg D, Battinelli EM, Luskin MR, Tothova Z, Morgan EA, Ebert BL.   +10 more
europepmc   +1 more source

Hyponatraemia Syndrome in Acute Myeloid Leukaemia [PDF]

, 1974
M. Amin Mir, I. W. Delamore
openalex   +1 more source

Single‐Cell Transcriptomics Unravels Growth Factor Erv1‐Like Mediated Ferroptosis as a Key Driver of Intestinal Epithelial Dysfunction in Ulcerative Colitis

Advanced Science, EarlyView.
Single‐cell transcriptomic profiling of ulcerative colitis (UC) tissues identified downregulation of GFER in intestinal epithelial cells. Mechanistically, GFER interacts with PCBP1 to help maintain intracellular iron homeostasis and may also reduce lipid peroxidation by activating the PGC‐1α/PPARγ signaling pathway, thereby inhibiting ferroptosis ...
Ya Song, Fangyan Tan, Qian Song, Xiaohui Liao, Zhechuan Mei, Lin Lv   +5 more
wiley   +1 more source

Myeloid ZNRF1 suppresses autoimmune demyelination and neuroinflammation by regulating MHC-II-mediated T cell activation. [PDF]

J Neuroinflammation
Chang YC, Wu CC, Hsiao FT, Lin YS, Lai TY, Huang KH, Tang SC, Lee CY, Chou SJ, Hsu LC.   +9 more
europepmc   +1 more source

Blood signals: from birth to disease and death

, 2014
Bowman, T., Flores-Figueroa, E., King, K., Kokkaliaris, K., Lessard, J., Trompouki, E., Will, B.   +6 more
core   +1 more source

Juvenile myeloid leukemia with fetal erythropoiesis [PDF]

, 1972
Yehudah Shapira, Aaron Polliack, Gabriel Cividalli, Eliezer A. Rachmilewitz   +3 more
openalex   +1 more source

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

Advanced Science, EarlyView.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang, Yiran Fang, Xiatong Huang, Guichuang Ma, Qianqian Mao, Xiansheng Lu, Guangda Rong, Yunfang Yu, Yuanyuan Wang, Zhenhua Huang, Huiying Sun, Jiani Wu, Wenchao Gu, Na Huang, Jianhua Wu, Rui Zhou, Xiaoxiang Rong, Siting Zheng, Shaowei Li, Gaofeng Wang, Ling Wang, Wenjun Qiu, Luyang Jiang, Peng Luo, Yonggang Liu, Jianping Bin, Yulin Liao, Min Shi, Zuqiang Wu, Jiguang Wang, Wangjun Liao, Gang Chen, Dongqiang Zeng   +32 more
wiley   +1 more source

Mitochondrial dysfunction in myeloid cells: a central deficit in autoimmune diseases. [PDF]

Trends Immunol
Kwong CJ, Kaplan MJ.
europepmc   +1 more source