Results 271 to 280 of about 523,497 (297)
Some of the next articles are maybe not open access.
The Lancet, 2006
Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haemopoietic progenitor cells and the most common malignant myeloid disorder in adults. The median age at presentation for patients with AML is 70 years. In the past few years, research in molecular biology has been instrumental in deciphering the pathogenesis of the disease.
Elihu, Estey, Hartmut, Döhner
openaire +2 more sources
Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haemopoietic progenitor cells and the most common malignant myeloid disorder in adults. The median age at presentation for patients with AML is 70 years. In the past few years, research in molecular biology has been instrumental in deciphering the pathogenesis of the disease.
Elihu, Estey, Hartmut, Döhner
openaire +2 more sources
Hematology, 2003
AbstractChronic myeloid leukemia (CML) was the first human malignancy to be associated with a specific genetic lesion, the Philadelphia chromosome, harboring the BCR-ABL oncogene. Since then, it has become a paradigm for the discovery of molecular mechanisms and targeted therapeutic approaches in the field of hematologic neoplasias. The past 5 years or
Junia V, Melo +2 more
openaire +2 more sources
AbstractChronic myeloid leukemia (CML) was the first human malignancy to be associated with a specific genetic lesion, the Philadelphia chromosome, harboring the BCR-ABL oncogene. Since then, it has become a paradigm for the discovery of molecular mechanisms and targeted therapeutic approaches in the field of hematologic neoplasias. The past 5 years or
Junia V, Melo +2 more
openaire +2 more sources
Orbit, 2016
Re: Grigalunas AL, Mizen TR. Myeloid sarcoma of the orbit without systemic recurrence of disease in an adult: A clinicopathological case report.
Kamal Kant, Sahu +2 more
openaire +2 more sources
Re: Grigalunas AL, Mizen TR. Myeloid sarcoma of the orbit without systemic recurrence of disease in an adult: A clinicopathological case report.
Kamal Kant, Sahu +2 more
openaire +2 more sources
Nature Reviews Disease Primers, 2016
Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of myeloid cells results in a high level of immature malignant cells and fewer differentiated red blood cells, platelets and white blood cells. The disease occurs at all ages,
Khwaja, A +12 more
openaire +2 more sources
Acute myeloid leukaemia (AML) is a disorder characterized by a clonal proliferation derived from primitive haematopoietic stem cells or progenitor cells. Abnormal differentiation of myeloid cells results in a high level of immature malignant cells and fewer differentiated red blood cells, platelets and white blood cells. The disease occurs at all ages,
Khwaja, A +12 more
openaire +2 more sources
Eosinophilic myeloid neoplasms
Current Opinion in Hematology, 2013In 2012, idiopathic hypereosinophilic syndrome (HES) is still the prevalent diagnosis in patients with persistent eosinophilia, in which a primary or secondary cause of eosinophilia has not been identified. HES is considered a provisional diagnosis until a primary or secondary cause of hypereosinophilia is established.
Pierre, Noel, Ruben A, Mesa
openaire +2 more sources
The Lancet, 2007
Chronic myeloid leukaemia (CML) was the first neoplastic disease for which knowledge of the genotype led to a rationally designed therapy. As a result of its well known pathophysiology, straightforward diagnosis, well established prognostic factors, and treatment for the cause of disease, CML has been studied to an extent that far exceeds that expected
Hehlmann R +3 more
openaire +3 more sources
Chronic myeloid leukaemia (CML) was the first neoplastic disease for which knowledge of the genotype led to a rationally designed therapy. As a result of its well known pathophysiology, straightforward diagnosis, well established prognostic factors, and treatment for the cause of disease, CML has been studied to an extent that far exceeds that expected
Hehlmann R +3 more
openaire +3 more sources
Eosinophilic Myeloid Disorders
Seminars in Hematology, 2012The discovery of therapeutically relevant mutations involving platelet-derived growth factor receptors alpha and beta (PDGFRA and PDGFRB) changed the way we evaluate and treat patients with clonal eosinophilia. Despite our improved understanding of the pathobiology of clonal eosinophilia, more than 50% of patients are diagnosed with idiopathic disease,
openaire +2 more sources
Hereditary myeloid malignancies
Best Practice & Research Clinical Haematology, 2019Myelodysplastic syndromes and acute myeloid leukemia are sporadic for the majority of cases affecting the elderly population. Inherited cases, however, do occur. Genetic predispositions to myeloid malignancies can be classified into three categories: familial cancer syndromes associated with increased risk of various malignancies including ...
Hind, Rafei, Courtney D, DiNardo
openaire +2 more sources
The Lancet, 2018
For several decades, few substantial therapeutic advances have been made for patients with acute myeloid leukaemia. However, since 2017 unprecedented growth has been seen in the number of drugs available for the treatment of acute myeloid leukaemia, with several new drugs receiving regulatory approval.
Nicholas J, Short +2 more
openaire +2 more sources
For several decades, few substantial therapeutic advances have been made for patients with acute myeloid leukaemia. However, since 2017 unprecedented growth has been seen in the number of drugs available for the treatment of acute myeloid leukaemia, with several new drugs receiving regulatory approval.
Nicholas J, Short +2 more
openaire +2 more sources
Best Practice & Research Clinical Haematology, 2001
Childhood myeloid leukaemias are a diverse collection of conditions. Although many are also seen in adults, some are peculiar to childhood. In childhood AML, as in adults, cytogenetic abnormalities are associated with specific clinical features and define prognostic groups.
openaire +2 more sources
Childhood myeloid leukaemias are a diverse collection of conditions. Although many are also seen in adults, some are peculiar to childhood. In childhood AML, as in adults, cytogenetic abnormalities are associated with specific clinical features and define prognostic groups.
openaire +2 more sources