Results 1 to 10 of about 72,140 (72)

Knockdown of Myeloid Cell Leukemia-1 by MicroRNA-101 Increases Sensitivity of A549 Lung Cancer Cells to Etoposide [PDF]

Iranian Journal of Medical Sciences, 2021
Background: Studies have shown that myeloid cell leukemia-1 (Mcl-1) is the target gene for microRNA -101 (miRNA-101), and decreased levels of miRNA-101 are associated with elevated levels of Mcl-1 and lung cancer survival.
Mahshid Shahverdi, Jamal Amri, Hadi Karami, Maryam Baazm   +3 more
doaj   +1 more source

Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance. [PDF]

PLoS Pathogens, 2011
The rise in type 1 diabetes (T1D) incidence in recent decades is probably related to modifications in environmental factors. Viruses are among the putative environmental triggers of T1D.
Maikel L Colli, Tatiane C Nogueira, Florent Allagnat, Daniel A Cunha, Esteban N Gurzov, Alessandra K Cardozo, Merja Roivainen, Anne Op de Beeck, Decio L Eizirik   +8 more
doaj   +1 more source

OTUD1 Activates Caspase‐Independent and Caspase‐Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation

Advanced Science, 2021
Apoptosis‐inducing factor (AIF) plays a dual role in regulating cell survival and apoptosis, acting as a prosurvival factor in mitochondria via its NADH oxidoreductase activity and activating the caspase‐independent apoptotic pathway (i.e., parthanatos ...
Qingyu Luo, Xiaowei Wu, Pengfei Zhao, Yabing Nan, Wan Chang, Xiaolin Zhu, Dan Su, Zhihua Liu   +7 more
doaj   +1 more source

REV3L, a promising target in regulating the chemosensitivity of cervical cancer cells. [PDF]

PLoS ONE, 2015
REV3L, the catalytic subunit of DNA Polymerase ζ (Polζ), plays a significant role in the DNA damage tolerance mechanism of translesion synthesis (TLS). The role of REV3L in chemosensitivity of cervical cancer needs exploration.
Li Yang, Tingyan Shi, Fei Liu, Chunxia Ren, Ziliang Wang, Yingyi Li, Xiaoyu Tu, Gong Yang, Xi Cheng   +8 more
doaj   +1 more source

Recombinant purified buffalo leukemia inhibitory factor plays an inhibitory role in cell growth. [PDF]

PLoS ONE, 2018
Leukemia Inhibitory Factor (LIF) is a polyfunctional cytokine, involved in numerous regulatory effects in vivo and in vitro, varying from cell proliferation to differentiation, and has therapeutic potential for treating various diseases.
Syed Azmal Ali, Dhruba Malakar, Jai Kumar Kaushik, Ashok Kumar Mohanty, Sudarshan Kumar   +4 more
doaj   +1 more source

Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p53 and INK4 protein families.

PLoS ONE, 2023
B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove found in ...
Anna McGriff, William J Placzek
doaj   +1 more source

Immediate early response 3 gene promotes aggressive progression and autophagy of AML by negatively regulating AKT/mTOR

Translational Oncology, 2023
Background: Immediate early response 3 (IER3) plays a vital role in many tumors. This study aims to explore the function and mechanism of IER3 in Acute myeloid leukemia (AML).
Yimin Chen, Zhenqian Huang, Shuyi Chen, Li Tan, Lang He, Danyun Yuan, Lixia Zheng, Jing hua Zhong, Anqiao Li, Heng Zhang, Huo Tan, Lihua Xu   +11 more
doaj   +1 more source

A novel requirement for Janus kinases as mediators of drug resistance induced by fibroblast growth factor-2 in human cancer cells. [PDF]

PLoS ONE, 2011
The development of resistance to chemotherapy is a major cause of cancer-related death. Elucidating the mechanisms of drug resistance should thus lead to novel therapeutic strategies.
Catarina R Carmo, Janet Lyons-Lewis, Michael J Seckl, Ana P Costa-Pereira   +3 more
doaj   +1 more source

Prognostic Significance of the Lymphoblastic Leukemia-Derived Sequence 1 (LYL1) Gene Expression in Egyptian Patients with Acute Myeloid Leukemia

Turkish Journal of Hematology, 2014
OBJECTIVE: Aberrant activation of transcription factor genes is the most frequent target of genetic alteration in lymphoid malignancies. The lymphoblastic leukemia-derived sequence 1 (LYL1) gene, which encodes a basic helix-loop helix, was first ...
Nadia El Menshawy, Doaa Shahin, Hayam Fathi Ghazi   +2 more
doaj   +1 more source

Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer

Journal of Experimental & Clinical Cancer Research, 2020
Background Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC).
Xinyou Yu, Feng Gao, Wei Li, Li Zhou, Wenbin Liu, Ming Li   +5 more
doaj   +1 more source