Results 11 to 20 of about 72,146 (78)

The FBXW7‐NOTCH interactome: A ubiquitin proteasomal system‐induced crosstalk modulating oncogenic transformation in human tissues

Cancer Reports, 2021
Background Ubiquitin ligases or E3 ligases are well programmed to regulate molecular interactions that operate at a post‐translational level. Skp, Cullin, F‐box containing complex (or SCF complex) is a multidomain E3 ligase known to mediate the ...
Rohan Kar, Saurabh Kumar Jha, Shreesh Ojha, Ankur Sharma, Sunny Dholpuria, Venkata Sita Rama Raju, Parteek Prasher, Dinesh Kumar Chellappan, Gaurav Gupta, Sachin KumarSingh, Keshav Raj Paudel, Philip M. Hansbro, Sandeep KumarSingh, Janne Ruokolainen, Kavindra Kumar Kesari, Kamal Dua, Niraj Kumar Jha   +16 more
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The biology of SCUBE

Journal of Biomedical Science, 2023
The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins in vertebrates, SCUBE1, 2 and 3, which are highly conserved in zebrafish, mice and humans.
Yuh-Charn Lin, Binay K. Sahoo, Shiang-Shin Gau, Ruey-Bing Yang   +3 more
doaj   +1 more source

Decreased SATB1 expression promotes AML cell proliferation through NF-κB activation

Cancer Cell International, 2019
Background Special AT-rich sequence-binding protein 1 (SATB1) is a chromatin-remodeling protein that regulates gene expressions in different types of cancer. Up-regulation of SATB1 is linked with progression of tumors.
Xiaodan Luo, Lihua Xu, Xiaohong Wu, Huo Tan, Lian Liu   +4 more
doaj   +1 more source

Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates

Nanomaterials, 2019
This study aimed to evaluate the anti-cancer effect of a combination therapy of miRNA-29b and genistein loaded in mucin-1 (MUC 1)-aptamer functionalized hybrid nanoparticles in non-small cell lung cancer (NSCLC) A549 cell line. Genistein-miRNA-29b-loaded
Koita Sacko, Karthik Thangavel, Sunday A. Shoyele   +2 more
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Shrimp miR-965 induced the human melanoma stem-like cell apoptosis and inhibited their stemness by disrupting the MCL-1-ER stress-XBP1 feedback loop in a cross-species manner

Stem Cell Research & Therapy, 2020
Background Melanoma is a type of aggressive skin cancer with a poor survival rate. The resistance to conventional therapy of this disease is, at least in part, attributed to its cancer stem cell population. However, the mechanism of survival and stemness
Wenlin Wu, Chenxi Xu, Xiaobo Zhang, An Yu, Le Shu   +4 more
doaj   +1 more source

MiR-130a is aberrantly overexpressed in adult acute myeloid leukemia with t(8;21) and its suppression induces AML cell death

Upsala Journal of Medical Sciences, 2018
Background: Emerging evidence has revealed that miRNAs can function as oncogenes or tumor suppressor genes in leukemia. The ectopic expression of miR-130a has been reported in chronic leukemia, but our understanding of the biological implications of miR ...
Chao Ding, Su-Ning Chen, Roderick A. F. Macleod, Hans G. Drexler, Stefan Nagel, De-Pei Wu, Ai-Ning Sun, Hai-Ping Dai   +7 more
doaj   +1 more source

Mutation or loss of Wilms' tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination

Journal of Translational Medicine, 2010
Background Efficacy of cancer vaccines may be limited due to immune escape mechanisms like loss or mutation of target antigens. Here, we analyzed 10 HLA-A2 positive patients with acute myeloid leukemia (AML) for loss or mutations of the WT1 epitope or ...
Ochsenreither Sebastian, Nonnenmacher Anika, Scheibenbogen Carmen, Letsch Anne, Busse Antonia, Thiel Eckhard, Keilholz Ulrich   +6 more
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Deubiquitinase USP9x Confers Radioresistance through Stabilization of Mcl-1

Neoplasia: An International Journal for Oncology Research, 2012
Myeloid cell leukemia sequence 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family, is often overexpressed in tumor cells limiting the therapeutic success. Mcl-1 differs from other Bcl-2 members by its high turnover rate.
Donatella Trivigno, Frank Essmann, Stephan M Huber, Justine Rudner   +3 more
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Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer

Molecular Therapy: Nucleic Acids, 2013
MicroRNA-29b (miR-29b) expression has been shown to be reduced in non-small–cell lung cancer (NSCLC) tissues. Here, we have identified the oncogene cyclin-dependent protein kinase 6 (CDK6) as a direct target of miR-29b in lung cancer.
Yun Wu, Melissa Crawford, Yicheng Mao, Robert J Lee, Ian C Davis, Terry S Elton, L James Lee, Serge P Nana-Sinkam   +7 more
doaj   +1 more source

Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis

Neoplasia: An International Journal for Oncology Research, 2013
Owing to the high levels of antiapoptotic B-cell lymphoma 2 (BCL-2) family members observed in several cancers, there has been a major effort to develop inhibitors of the BCL2-family as chemotherapeutic agents.
Shankar Varadarajan, Michael Butterworth, Jun Wei, Maurizio Pellecchia, David Dinsdale, Gerald M Cohen   +5 more
doaj   +1 more source