Results 21 to 30 of about 72,146 (78)

Targeted disruption of the BCR-ABL fusion gene by Cas9/dual-sgRNA inhibits proliferation and induces apoptosis in chronic myeloid leukemia cells

Acta Biochimica et Biophysica Sinica
The BCR-ABL fusion gene, formed by the fusion of the breakpoint cluster region protein (BCR) and the Abl Oncogene 1, Receptor Tyrosine Kinase (ABL) genes, encodes the BCR-ABL oncoprotein, which plays a crucial role in leukemogenesis.
Zeng Jianling, Liang Xinquan, Duan Lili, Tan Fenghua, Chen Liujie, Qu Jiayao, Li Jia, Li Kai, Luo Dixian, Hu Zheng   +9 more
doaj   +1 more source

YX0798 is a highly potent, selective, and orally effective CDK9 inhibitor for treating aggressive lymphoma

Blood Advances
: Nongenetic transcription evolution has been increasingly explored and recognized to drive tumor cell progression and therapeutic resistance. As the regulation hub of transcription machinery, cyclin-dependent kinase 9 (CDK9) is the gatekeeper of RNA ...
Vivian Jiang, Yu Xue, Hong Kim, Qingsong Cai, Tianci Zhang, Lei Nie, Joseph McIntosh, Yang Liu, Haiying Chen, Jia Zhou, Michael Wang   +10 more
doaj   +1 more source

Activating Transcription Factor-6 (ATF6) Mediates Apoptosis with Reduction of Myeloid Cell Leukemia Sequence 1 (Mcl-1) Protein via Induction of WW Domain Binding Protein 1 [PDF]

, 2011
Nobuhiro Morishima, Keiko Nakanishi, Akihiko Nakano   +2 more
openalex   +1 more source

Emetine enhances the tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of pancreatic cancer cells by downregulation of myeloid cell leukemia sequence-1 protein

, 2013
YUJEONG HAN, Sojung Park, Ann W. Kinyua, Ladislav Anděra, Ki Woo Kim, Inki Kim   +5 more
openalex   +2 more sources

Expression of heat shock protein gp96, myeloid cell leukemia sequence-1 and prohibitin in liver cirrhosis and hepatocellular carcinoma

, 2008
Ting-yan Hua, Jie-Fei Huang, Hong Zhang, Dong-Feng Huang, Qun Wei   +4 more
openalex   +1 more source

Identification of two novel TP53 mutations in secondary acute myeloid leukemia following multiple myeloma: a case report. [PDF]

Blood Sci
De Francesco MA, Ribolla R, Sottini A, Bertoli D, Giupponi C, Bonuccelli O, Bresciani R, Tucci A, Biasiotto G.   +8 more
europepmc   +1 more source

The oncogenic role of ecotropic viral integration site 1 in hematological malignancies: mechanisms of activation and leukemogenesis. [PDF]

Front Immunol
Hao Y, Liu J, Lou J, Yan J.
europepmc   +1 more source

A Review of CEBPA's Role in Hereditary Leukemia. [PDF]

EJHaem
Rakiewicz T, Palmisiano N.
europepmc   +1 more source

Acute promyelocytic leukemia with a novel TTMV::RARA fusion initially presenting as vertebral myeloid sarcoma: a case report. [PDF]

Front Oncol
Ruijia L, Qianqian Z, Xiaohong L, Sen Y, Nan Z, Jing L.   +5 more
europepmc   +1 more source

Antiapoptotic BCL2 family proteins BCL-XL and MCL1 as factors predicting resistance against venetoclax plus azacitidine for patients with newly diagnosed acute myelogenous leukemia. [PDF]

PLoS One
Kamihara Y, Kikuchi S, Ishikawa N, Shinomiya N, Kunimoto K, Horaguchi R, Fujihira T, Nabe Y, Minemura T, Ono K, Wada A, Dang NH, Sato T.   +12 more
europepmc   +1 more source