Results 251 to 260 of about 160,066 (290)

Two myeloid differentiation factor 88 (MyD88) isoforms identified in ducks

Developmental & Comparative Immunology, 2015
MyD88 is an adaptor protein involved in the interleukin-1 receptor-induced and Toll-like receptor (TLR)-induced activation of nuclear factor-κB (NF-κB). In this study, we identified two isoforms of MyD88 gene, designated DuMyD88-X1 and DuMyD88-X2, from duck cells.
Yuqiang, Cheng, Hengan, Wang, Yaxian, Yan, Chan, Ding, Jianhe, Sun   +4 more
openaire   +2 more sources

Design, Synthesis, and In Vitro Activity of Peptidomimetic Inhibitors of Myeloid Differentiation Factor 88

Journal of Medicinal Chemistry, 2008
We describe the design and synthesis of a peptidomimetic library derived from the heptapeptide Ac-RDVLPGT-NH 2, belonging to the Toll/IL-1 receptor (TIR) domain of the adaptor protein MyD88 and effective in inhibiting its homodimerization. The ability of the peptidomimetics to inhibit protein-protein interaction was assessed by yeast 2-hybrid assay and
Nicola, Fantò, Grazia, Gallo, Andrea, Ciacci, Mauro, Semproni, Davide, Vignola, Marco, Quaglia, Valentina, Bombardi, Domenico, Mastroianni, M Pia, Zibella, Giancarlo, Basile, Marica, Sassano, Vito, Ruggiero, Rita, De Santis, Paolo, Carminati   +13 more
openaire   +2 more sources

Role of myeloid differentiation factor 88 in HSP60 signal transduction in dendritic cells

Journal of Nanjing Medical University, 2007
Abstract Objective To explore the role and mechanism of myeloid differentiation factor88 (MyD88) in HSP60 signal transduction in dendritic cells. Methods Mouse DCs were cultured from murine bone marrow cells. The DC marker CD11c was detected by flow cytometry, then DCs were divided into control group, HSP60 groupand RNA interference group ...
Jiajun Chen, Zongquan Sun, Gang Su, Chao Liu, Jinping Liu, Yongzhi Deng, Jiawei Shi   +6 more
openaire   +1 more source

Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88)

Developmental & Comparative Immunology, 2008
Myeloid differentiation factor 88 (MyD88) is an adaptor protein involved in the interleukin-1 receptor- and Toll-like receptor-induced activation of nuclear factor-kappaB (NF-kappaB). A novel isoform of chicken MyD88, designated chicken MyD88-2, has been cloned and functionally characterized.
Yafeng, Qiu, Yang, Shen, Xiangdong, Li, Chan, Ding, Zhiyong, Ma   +4 more
openaire   +2 more sources

Contribution of Toll‐like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration†

Hepatology, 2005
Toll-like receptors (TLRs) act as innate immune signal sensors and play central roles in host defense. Myeloid differentiation factor (MyD) 88 is a common adaptor molecule required for signaling mediated by TLRs. When the receptors are activated, cells bearing TLRs produce various proinflammatory cytokines in a MyD88-dependent manner.
Ekihiro, Seki, Hiroko, Tsutsui, Yuji, Iimuro, Tetsuji, Naka, Gakuhei, Son, Shizuo, Akira, Tadamitsu, Kishimoto, Kenji, Nakanishi, Jiro, Fujimoto   +8 more
openaire   +2 more sources

Characterization and expression analysis of the myeloid differentiation factor 88 (MyD88) in rock bream Oplegnathus fasciatus

Molecular Biology Reports, 2010
Myeloid differentiation factor 88 (MyD88) is a universal adaptor protein able to activate nuclear factor-kappa B (NF-κB) through interactions with interleukin-1 receptor (IL-1R) and the Toll-like receptors (TLRs), with the exception of TLR3. Here, we describe the identification of MyD88 from the rock bream fish Oplegnathus fasciatus and its ...
Ilson, Whang, Youngdeuk, Lee, Hyowon, Kim, Sung-Ju, Jung, Myung-Joo, Oh, Cheol Young, Choi, Woo Song, Lee, Se-Jae, Kim, Jehee, Lee   +8 more
openaire   +2 more sources

Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats

Experimental Neurology, 2017
Accumulating evidence supports that activation of inflammatory pathways is a crucial factor contributing to the pathogenesis of seizures. In particular, the activation of interleukin-1 beta (IL-1β) system exerts proconvulsant effects in a large variety of seizure models.
Na, Wang, Xiong, Han, Haipeng, Liu, Ting, Zhao, Jie, Li, Yan, Feng, Xiujuan, Mi, Yanke, Zhang, Yanan, Chen, Xuefeng, Wang   +9 more
openaire   +2 more sources

Identification, functional characterization and expression pattern of myeloid differentiation factor 88 (MyD88) in Sepiella japonica

Fish & Shellfish Immunology, 2018
Myeloid differentiation factor 88 (MyD88) is an adaptor protein involved in the interleukin-1 receptor and Toll-like receptor-induced activation of nuclear factor-κB (NF-κB). In this study a novel isoform of MyD88 in Sepiella japonica (SjMyD88) was cloned and functionally characterized (GenBank accession no. AQY56781.1).
Liping, Huo, Miaomiao, Bao, Zhenming, Lv, Changfeng, Chi, Tianming, Wang, Huihui, Liu   +5 more
openaire   +2 more sources

Myeloid differentiation factor 88 gene is involved in antiviral immunity in grass carp Ctenopharyngodon idella

Journal of Fish Biology, 2011
A full-length MyD88 cDNA (CiMyD88) was cloned and characterized from grass carp Ctenopharyngodon idella. CiMyD88 was found to be broadly expressed and was up-regulated by grass carp reovirus (GCRV) and CiMyD88 transcripts in vitro were rapidly elevated in C. idella kidney (CIK) cells after challenge with poly(I:C).
J, Su, J, Dong, T, Huang, R, Zhang, C, Yang, J, Heng   +5 more
openaire   +2 more sources

Clinical and pathological significance of myeloid differentiation factor 88 expression in human hepatocellular carcinoma tissues

Pathology International, 2017
The innate immune system, which includes toll‐like receptor (TLR) signaling, plays an important role in inflammation and oncogenesis. Although TLR common adaptor myeloid differentiation factor 88 (MyD88) is known to have multiple effects on carcinogenesis, the role of MyD88 in hepatocarcinogenesis remains unknown.
Keiichi, Kinowaki, Yurie, Soejima, Arisa, Kumagai, Fukuo, Kondo, Keiji, Sano, Takeshi, Fujii, Masanobu, Kitagawa, Toshio, Fukusato   +7 more
openaire   +2 more sources