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The consequences of cohesin mutations in myeloid malignancies
Frontiers in Molecular Biosciences, 2023 Recurrent somatic mutations in the genes encoding the chromatin-regulatory cohesin complex and its modulators occur in a wide range of human malignancies including a high frequency in myeloid neoplasms. The cohesin complex has a ring-like structure which
Shubhra Ashish Bhattacharya +6 more
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Classification of Acute Leukaemia based on Blast Morphology, Cytochemistry and Flow Cytometry [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Acute leukaemias are a heterogeneous group of malignancies due to the abnormal proliferation of immature cells. The classification of acute leukaemia has been transformed over a period.
P Jubit Paulose, J Latha Fathima
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Adult type CML in paediatric age group – a case series from tertiary care hospital
Asian Journal of Medical Sciences, 2021 Chronic myeloid leukaemia is a clonal disorder arising from hematopoietic stem cell, affecting all the lineage of haematopoietic stem cells. The average age of affection in chronic myeloid leukaemia is 60 to 65 years and is extremely rare in childhood ...
Sumaiya Irfan +3 more
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Epitope editing enables targeted immunotherapy of acute myeloid leukaemia
Nature, 2023 Despite the considerable efficacy observed when targeting a dispensable lineage antigen, such as CD19 in B cell acute lymphoblastic leukaemia^ 1 , 2 , the broader applicability of adoptive immunotherapies is hampered by the absence of tumour-restricted ...
Gabriele Casirati +15 more
semanticscholar +1 more source
Nature Cell Biology, 2023 N ^6-methyladenosine (m^6A) methylation can be deposited on chromatin-associated RNAs (caRNAs) by the RNA methyltransferase complex (MTC) to regulate chromatin state and transcription.
Xiaoyang Dou +18 more
semanticscholar +1 more source
Autoimmunity, 2021 Odd-skipped related transcription factor 1 (OSR1) is implicated in various pathophysiologic processes, such as embryonic heart and urogenital formation, and functions as a tumour suppressor in diverse tumours.
Lingyan Zong, Yingxin Sun
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Leukaemic Ascites and Peritoneal Myeloid Sarcoma: Rare but Not Impossible
European Journal of Case Reports in Internal Medicine, 2022 A myeloid sarcoma is an extramedullary tumour arising from infiltration by leukemic cells at an anatomic site other than the bone marrow. Most commonly it precedes acute myeloid leukaemia but occasionally occurs simultaneously.
Luís Landeiro +4 more
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Nature Communications, 2022 The gut microbiota has been linked to many cancers, yet its role in acute myeloid leukaemia (AML) progression remains unclear. Here, we show decreased diversity in the gut microbiota of AML patients or murine models.
Ruiqing Wang +8 more
semanticscholar +1 more source
Journal of Translational Medicine, 2022 Background The survival rate for patients with relapsed and refractory acute myeloid leukaemia (R/R-AML) remains poor, and treatment is challenging.
Yu Lu +6 more
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Spinal Chloroma – Herald of blast crisis in a patient with chronic myeloid leukaemia: A case report
South African Journal of Radiology, 2022 Myeloid sarcoma or chloroma is a localised tumour characterised by extramedullary proliferation of precursor myeloid cells. Commonly occurring in association with acute myeloid leukaemia, chloroma can occasionally be seen in myeloproliferative disorders ...
Stuti Chandola +3 more
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