Results 161 to 170 of about 301,311 (355)

CXCR1 Depletion in Ly6C+ cDC2 Alleviates Acute Lung Injury via Modulation of Th17/Treg Balance

Advanced Science, EarlyView.
Pro‐inflammatory Ly6C⁺ cDC2s are identified as key effector cells mediating Cxcr1 signaling, driving the progression of ALI. Ly6C⁺ cDC2s release high levels of Il‐6 and Il‐1β, inducing Th17 differentiation. Cxcr1 deficiency reduces Il‐6 and Il‐1β production from Ly6C⁺ cDC2s through suppressing MEK1/ERK /NF‐κB signaling, thereby shifts naïve T cells ...
Shenghui Li, Wei Zhuang, Yang Wang, Hao Qin, Xichun Qin, Xianliang Yan, Xuefei Hu, Xiucheng Liu, Chang Chen   +8 more
wiley   +1 more source

Piplartine eliminates CD34 + AML stem/progenitor cells by inducing oxidative stress and suppressing NF-κB signalling

Cell Death Discovery
Acute myeloid leukaemia (AML) is a haematological malignancy characterised by the accumulation of transformed myeloid progenitors in the bone marrow. Piplartine (PL), also known as piperlongumine, is a pro-oxidant small molecule extracted from peppers ...
Ana Carolina B. da C. Rodrigues, Suellen L. R. Silva, Ingrid R. S. B. Dias, Rafaela G. A. Costa, Maiara de S. Oliveira, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Emily M. Johnson, Cristina Pina, Daniel P. Bezerra   +11 more
doaj   +1 more source

Cardiovascular toxicity induced by TKIs in patients with chronic myeloid leukaemia: Are women and men different? [PDF]

ESC Heart Fail
This study analyzes 148 patients (66 women and 82 men) with chronic myeloid leukemia treated with tyrosine kinase inhibitors, focusing on cardiovascular adverse events. The risk assessment, performed using the HFA/ICOS score, reveals sex‐specific differences: venous thrombosis is more common in women, while arterial thrombosis predominates in men.
Madaudo C, Di Lisi D, Cannatà A, Manfrè F, Vullo C, Santoro M, Botta C, Mancuso S, Siragusa S, Galassi AR, Novo G.   +10 more
europepmc   +2 more sources

Characteristics of murine myeloid leukaemia colonies in the spleen.

, 1969
T Tanaka, L. G. Lajtha
openalex   +1 more source

Acute myeloid leukaemia in pregnancy [PDF]

British Journal of Haematology, 2015
Emma Das-Gupta, Andrew McGregor
openaire   +2 more sources

A Network‐Driven Framework for Drug Response Precision Prediction of Acute Myeloid Leukemia

Advanced Science, EarlyView.
A network‐based precision medicine platform, named NetAML is offered for personalized treatment of AML. It combines network analysis and machine learning to develop 87 models predicting drug sensitivity for clinical drugs. NetAML identifies interpretable gene signatures that drive differential drug responses, enabling the prediction of individual ...
Yinyin Wang, Rui Liu, Yinnan Zhang, Xiang Luo, Chengzhuang Yu, Shentong Fang, Ninghua Tan, Jing Tang   +7 more
wiley   +1 more source

Pulmonary function after bone marrow transplantation for chronic myeloid leukaemia. [PDF]

, 1988
Tom G. Sutedja, Jane F. Apperley, J. M. B. Hughes, V R Aber, Harry Kennedy, Peter B. Nunn, Lydia Jones, Laura Rose Hopper, John M. Goldman   +8 more
openalex   +1 more source

ASO Therapy Targeting STAU2 to Inhibit Pancreatic Ductal Adenocarcinoma Progression and Metastasis by Regulating the PALLD‐Mediated EMT Signaling Pathway

Advanced Science, EarlyView.
This study identifies STAU2 as an oncogenic RNA‐binding protein (RBP) with elevated expression in pancreatic ductal adenocarcinoma (PDAC), where its high levels are significantly correlated with metastatic progression. It elucidates that STAU2 directly binds and regulates PALLD, while mediating the functional role of IQGAP1, thereby driving metastasis ...
Jiayu Ding, Hao Shen, Jiaying Ji, Jiaxing Li, Zhongrui Shi, Xuejiao Wang, Bangbang Li, Yi Hou, Wenjian Min, Chengliang Sun, Kai Yuan, Yasheng Zhu, Liping Wang, Shun‐Qing Liang, Wenbin Kuang, Xiao Wang, Peng Yang   +16 more
wiley   +1 more source

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Nature, 2011
J. Zuber, Junwei Shi, E. Wang, Amy R. Rappaport, H. Herrmann, E. Sison, D. Magoon, J. Qi, Katharina Blatt, M. Wunderlich, Meredith J. Taylor, C. Johns, A. Chicas, J. Mulloy, S. Kogan, P. Brown, P. Valent, J. Bradner, S. Lowe, C. Vakoc   +19 more
semanticscholar   +1 more source

Cellular sensitization in chronic myeloid leukaemia patients to leukaemic blast antigens

, 1979
Sudha Gangal, NK Damle, Akriti Khare, Suresh H. Advani   +3 more
openalex   +1 more source