Results 261 to 270 of about 61,255 (306)
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The Lancet, 2015
Chronic myeloid leukaemia (CML) was the first leukaemia associated with a unique genetic abnormality, the Philadelphia chromosome. This results from a reciprocal translocation between chromosomes 9 and 22, which generates the BCR-ABL1 fusion gene encoding a constitutively active tyrosine kinase.
Debora A. Casolari, Junia V. Melo
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Chronic myeloid leukaemia (CML) was the first leukaemia associated with a unique genetic abnormality, the Philadelphia chromosome. This results from a reciprocal translocation between chromosomes 9 and 22, which generates the BCR-ABL1 fusion gene encoding a constitutively active tyrosine kinase.
Debora A. Casolari, Junia V. Melo
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The Lancet, 2018
For several decades, few substantial therapeutic advances have been made for patients with acute myeloid leukaemia. However, since 2017 unprecedented growth has been seen in the number of drugs available for the treatment of acute myeloid leukaemia, with several new drugs receiving regulatory approval.
Nicholas J, Short +2 more
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For several decades, few substantial therapeutic advances have been made for patients with acute myeloid leukaemia. However, since 2017 unprecedented growth has been seen in the number of drugs available for the treatment of acute myeloid leukaemia, with several new drugs receiving regulatory approval.
Nicholas J, Short +2 more
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The Lancet, 2007
Chronic myeloid leukaemia (CML) was the first neoplastic disease for which knowledge of the genotype led to a rationally designed therapy. As a result of its well known pathophysiology, straightforward diagnosis, well established prognostic factors, and treatment for the cause of disease, CML has been studied to an extent that far exceeds that expected
Hehlmann R +3 more
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Chronic myeloid leukaemia (CML) was the first neoplastic disease for which knowledge of the genotype led to a rationally designed therapy. As a result of its well known pathophysiology, straightforward diagnosis, well established prognostic factors, and treatment for the cause of disease, CML has been studied to an extent that far exceeds that expected
Hehlmann R +3 more
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Immunotherapy of myeloid leukaemia
Cancer Immunology, Immunotherapy, 2006The treatment of myeloid leukaemia has progressed in recent years with the advent of donor leukocyte infusions (DLI), haemopoietic stem cell transplants (HSCTs) and targeted therapies. However, relapse has a high associated morbidity rate and a method for removing diseased cells in first remission, when a minimal residual disease state is achieved and ...
Guinn, Barbara-Ann +3 more
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Best Practice & Research Clinical Haematology, 2001
Childhood myeloid leukaemias are a diverse collection of conditions. Although many are also seen in adults, some are peculiar to childhood. In childhood AML, as in adults, cytogenetic abnormalities are associated with specific clinical features and define prognostic groups.
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Childhood myeloid leukaemias are a diverse collection of conditions. Although many are also seen in adults, some are peculiar to childhood. In childhood AML, as in adults, cytogenetic abnormalities are associated with specific clinical features and define prognostic groups.
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Critical Reviews in Oncology/Hematology, 2004
The curability of acute myeloid leukaemia (AML) in a fraction of adult patients was demonstrated a long time ago. Currently, the probability of cure is consistently above fifty per cent in patients with de novo disease expressing favourable-risk associated cytogenetic features.
Matthew, Smith +5 more
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The curability of acute myeloid leukaemia (AML) in a fraction of adult patients was demonstrated a long time ago. Currently, the probability of cure is consistently above fifty per cent in patients with de novo disease expressing favourable-risk associated cytogenetic features.
Matthew, Smith +5 more
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British Medical Bulletin, 1996
There has been considerable progress in the understanding and treatment of childhood acute myeloid leukaemia over the past two decades. In particular, cyto- and molecular genetics offer the potential for more specific diagnosis of what is basically a heterogeneous disease.
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There has been considerable progress in the understanding and treatment of childhood acute myeloid leukaemia over the past two decades. In particular, cyto- and molecular genetics offer the potential for more specific diagnosis of what is basically a heterogeneous disease.
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Medicine, 2017
Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder resulting from a reciprocal translocation between the long arms of chromosomes 9 and 22. This is termed the Philadelphia chromosome, and leads to production of the fusion onco-protein BCR-ABL, a 210 kDa constitutively active tyrosine kinase.
Katharine Hanlon, Mhairi Copland
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Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder resulting from a reciprocal translocation between the long arms of chromosomes 9 and 22. This is termed the Philadelphia chromosome, and leads to production of the fusion onco-protein BCR-ABL, a 210 kDa constitutively active tyrosine kinase.
Katharine Hanlon, Mhairi Copland
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Medicine, 2004
Abstract Chronic myeloid leukaemia (CML, previously termed ‘chronic granulocytic leukaemia' or ‘chronic myelogenous leukaemia') appears to result from acquisition in a single pluripotent haemopoietic stem cell of a molecular lesion that causes inappropriate expansion of its progeny.
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Abstract Chronic myeloid leukaemia (CML, previously termed ‘chronic granulocytic leukaemia' or ‘chronic myelogenous leukaemia') appears to result from acquisition in a single pluripotent haemopoietic stem cell of a molecular lesion that causes inappropriate expansion of its progeny.
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2018
Chronic myeloid leukaemia (CML) was recognized in the 1970s by Janet Rowley to be a genetically simple malignancy; resulting as a consequence of a balanced translocation between chromosome 9 and 22. This provided vital insights into the molecular aberration, in the 1990s, which ushered in the current ‘precision medicine’ era, not only for patients of ...
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Chronic myeloid leukaemia (CML) was recognized in the 1970s by Janet Rowley to be a genetically simple malignancy; resulting as a consequence of a balanced translocation between chromosome 9 and 22. This provided vital insights into the molecular aberration, in the 1990s, which ushered in the current ‘precision medicine’ era, not only for patients of ...
openaire +1 more source