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2022
Acute myeloid leukaemia accounts for 15-20% of paediatric leukae-mia. This chapter describes the epidemiology, clinical features, inves-tigation, diagnosis and classification of acute myeloid leukaemia in children. Treatment with intensive chemotherapy and (in some chil-dren) haemopoietic stem cell transplantation, treatment complications and prognosis
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Acute myeloid leukaemia accounts for 15-20% of paediatric leukae-mia. This chapter describes the epidemiology, clinical features, inves-tigation, diagnosis and classification of acute myeloid leukaemia in children. Treatment with intensive chemotherapy and (in some chil-dren) haemopoietic stem cell transplantation, treatment complications and prognosis
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The Lancet, 2007
www.thelancet.com Vol 369 February 3, 2007 367 USA, 30–60 mg/day is an infrequently prescribed dose, whereas doses over 100 mg/day are now the norm. It is with consternation that we acknowledge the escalation of dosing standards as our best explanation for the increase in morbidity and mortality among methadone-treated patients.
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www.thelancet.com Vol 369 February 3, 2007 367 USA, 30–60 mg/day is an infrequently prescribed dose, whereas doses over 100 mg/day are now the norm. It is with consternation that we acknowledge the escalation of dosing standards as our best explanation for the increase in morbidity and mortality among methadone-treated patients.
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Medicine, 2013
Chronic myeloid leukaemia (CML) is a clonal disorder in which cells of the myeloid lineage undergo inappropriate clonal expansion, caused by a BCR–ABL1 fusion gene resulting from a balanced translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), also known as the Philadelphia (Ph) chromosome.
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Chronic myeloid leukaemia (CML) is a clonal disorder in which cells of the myeloid lineage undergo inappropriate clonal expansion, caused by a BCR–ABL1 fusion gene resulting from a balanced translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), also known as the Philadelphia (Ph) chromosome.
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1992
Although less frequent than acute lymphoblastic leukaemia (ALL) the incidence of acute myeloid leukaemia (AML) is still significant, constituting approximately 20% of childhood acute leukaemia cases in large series [1]. Compared with childhood ALL, the treatment of AML is less satisfactory because of (a) lower remission rate, (b) lower percentage of ...
M. L. N. Willoughby, B. Lampkin
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Although less frequent than acute lymphoblastic leukaemia (ALL) the incidence of acute myeloid leukaemia (AML) is still significant, constituting approximately 20% of childhood acute leukaemia cases in large series [1]. Compared with childhood ALL, the treatment of AML is less satisfactory because of (a) lower remission rate, (b) lower percentage of ...
M. L. N. Willoughby, B. Lampkin
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The clinical development of antibody–drug conjugates — lessons from leukaemia
Nature Reviews Clinical Oncology, 2021Elias J Jabbour +2 more
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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
Nature, 2021Eliza Yankova +2 more
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Treatment-free remission in patients with chronic myeloid leukaemia
Nature Reviews Clinical Oncology, 2020David Ross, Timothy P Hughes
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Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
Nature, 2022Jan Joseph Melenhorst +2 more
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Chronic lymphocytic leukaemia: from genetics to treatment
Nature Reviews Clinical Oncology, 2019Francesc Bosch
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