Results 281 to 290 of about 467,609 (357)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Neuronal Reshaping of the Tumor Microenvironment in Tumorigenesis and Metastasis: Bench to Clinic

Medicine Advances, EarlyView.
This graphical abstract illustrates the multidimensional crosstalk between neurons and tumor microenvironment as well as targeted intervention strategies identified in the study. It highlights three core interaction axes: nerve‐tumor crosstalk mediated by neurotransmitters and neurotrophic factors, neuro‐vascular communication driving angiogenesis via ...
Yimao Wu, Ruowei Sun, Shuai Ren, Gokhan Zengin, Mengyao Li   +4 more
wiley   +1 more source

Epidemiology of acute myeloid leukemia in children and adolescents (1990-2021): a global burden of disease study. [PDF]

Naturwissenschaften
Jia F, Li Y, Hao T, Ma G.
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Molecular abnormalities and clinical features in adult patients with acute myeloid leukemia in Thailand. [PDF]

Diagn Pathol
Chantrathammachart P, Jinawath A, Puavilai T, Arsa L, Police P, Noikongdee P, Phojanasenee T, Sae-Lim P, Piyajaroenkij T, Choksomnuk P, Chuncharunee S, Niparuck P.   +11 more
europepmc   +1 more source

Rib Ewing Sarcomas in Children and Young Adults: A Large National Retrospective Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Purpose Ewing sarcoma (ES) is the most prevalent malignant thoracic tumor in childhood and young adults. This study reports the outcome of a national cohort treated in an international prospective trial for a localized rib ES, with a long follow‐up.
Audrey Claren, Alexandre Beige, Magali Morelle, Jérôme Doyen, Cyril Lervat, Luc Ollivier, Cécile Vérité, Perrine Marec‐Bérard, Maria Jolnerovski, Anne Ducassou, Valentine Martin, Line Claude, French Multidisciplinary Working Group on Bone Primary Tumours (GROUPOS), GSF (French Sarcoma Group), GETO (Bone Tumour Study Group) and SFCE (French Society for the Fight against Childhood and Adolescent Cancer and Leukaemia)   +14 more
wiley   +1 more source

Aberrant expression of MAPK1 and MCTS1 in chronic myeloid leukemia (CML). [PDF]

MicroPubl Biol
Kortendick L, Meyer C, Nagel S.
europepmc   +1 more source

Detection of low abundance mRNA of myeloid specific genes in cells of acute and chronic lymphoid leukemias by cRNA hybridization.

, 1990
Sérgio Ferrari, G Ceccherelli, Enrico Tagliafico, Patrizia Zucchini, Rossella Manfredini, G Torelli, Giovanni Emilia, U Torelli   +7 more
openalex   +1 more source

Patient and Family Demographics in the Momcology Pediatric Cancer Patient Advocacy Organization

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Momcology is a US‐based patient advocacy organization that provides support for families of children with cancer. This study describes Momcology for researchers by detailing the demographic, clinical, and socioeconomic (socioeconomic status [SES]) data within its registry and comparing it to the National Surveillance, Epidemiology ...
Ryan Salama, Alexis Shuck, Zhanni Lu, Kimberly Buff, Michelle A. Roesler, Catherine Paciente, Logan G. Spector   +6 more
wiley   +1 more source

A Mutational Landscape in Acute Myeloid Leukemia: Overview and Prognostic Impacts. [PDF]

Diagnostics (Basel)
Chen J, Hassan F, Tirado CA.
europepmc   +1 more source