Results 281 to 290 of about 950,400 (402)

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, EarlyView.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

Acute Myeloid Leukemia With <i>NPM1</i> Mutation Presenting With Rapidly Progressing Hypereosinophilia. [PDF]

Case Rep Hematol
Einarsdottir S, Orrsjö G, von Bahr L, Staffas A, Fogelstrand L.   +4 more
europepmc   +1 more source

IMBALANCE IN NUCLEOTIDE POOLS OF MYELOID LEUKEMIA CELLS AND HL-60 CELLS: CORRELATION WITH CELL CYCLE PHASE,CELL PROLIFERATION AND DIFFERENTIATION: 53 [PDF]

, 1985
D De Korte, Willem A. Haverkort, Dirk Roos, A. H. van Gennip   +3 more
openalex   +1 more source

Somatic mutations precede acute myeloid leukemia years before diagnosis

Nature Network Boston, 2018
Pinkal M. Desai, N. Mencia-Trinchant, O. Savenkov, M. Simon, Gloria Cheang, Sangmin Lee, Michael B. Samuel, E. Ritchie, M. Guzman, K. Ballman, G. Roboz, D. Hassane   +11 more
semanticscholar   +1 more source

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, EarlyView.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Histologically verified penile lichen sclerosus—Incidence in Denmark over 26 years and long‐term risk of penile and non‐penile cancer

International Journal of Cancer, EarlyView.
What's New? About half of penile squamous cell carcinomas are causally associated with inflammatory conditions such as lichen sclerosus (LSc), but few large‐scale studies have assessed the risk of penile cancer in men with LSc. Here, the authors conducted a large nationwide study in Denmark to estimate the risk of penile and non‐penile cancer in men ...
Marianne Gardar Stærk, Emma L. Kaderly Rasmussen, Charlotte Gerd Hannibal, Rasmus Hertzum‐Larsen, Louise Baandrup, Susanne K. Kjær   +5 more
wiley   +1 more source

Acute Myeloid Leukemia with <i>NUP98::LNP1</i> Fusion Mimicking Chronic Myeloid Leukemia [PDF]

Turk J Haematol
Wang H, Peng Y, Yang Z.
europepmc   +1 more source

Establishment and characterization of a human myeloid cell line from Philadelphia chromosome-negative myeloblastic leukemia arising in a patient with myelodysplastic syndrome [PDF]

, 1987
TM McCarty, S. Rajaraman, FF Elder, Preston F. Gadson, E. Aubrey Thompson   +4 more
openalex   +1 more source

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

Nature Network Boston, 2018
D. Pollyea, Brett M. Stevens, Courtney L Jones, Amanda C. Winters, Shanshan Pei, Mohammad Minhajuddin, A. D’Alessandro, Rachel Culp-Hill, K. Riemondy, A. Gillen, J. Hesselberth, Diana Abbott, Derek Schatz, J. Gutman, E. Purev, Clayton A. Smith, C. Jordan   +16 more
semanticscholar   +1 more source

Apoptosis regulators of the Bcl‐2 family play a key role in chemoresistance of cholangiocarcinoma organoids

International Journal of Cancer, EarlyView.
What's New? Poor prognosis in cholangiocarcinoma (CCA) is attributed to late diagnosis and intrinsic chemoresistance. In particular, resistance mechanisms that suppress apoptosis limit the effectiveness of gemcitabine‐based regimens, which remain the standard treatment.
Wunan Mi, Gilles S. van Tienderen, Shaojun Shi, Amy Broeders, Kathryn Monfils, Henk P. Roest, Luc J. W. van der Laan, Monique M. A. Verstegen   +7 more
wiley   +1 more source