Results 321 to 330 of about 950,400 (402)

Childhood Cancer Survivors in Latin America: Insights Into Health Outcomes and Information Needs

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood cancer survivors (CCSs) face long‐term health challenges, yet the health and specific needs of Latin American survivors remain underexplored. This study aimed to describe the health‐related, psychosocial late effects, and information needs among CCSs in the region. Methods This mixed‐method study combined quantitative data
Ana Carolina Izurieta‐Pacheco, David H. Noyd, Julia Challinor, Nuria Rossell, Maria Fernanda Olarte‐Sierra, Daniel Bastardo Blanco, Marcela Zubieta, Nicholas B. George, Sara Perez‐Jaume, Anna Felip‐Badia, Viviana Trigoso, Patricia Loggetto, Valeska Gonzalez, Carlos Frias, Sinders Rincon, Roberta Ortiz, Soad Fuentes‐Alabi de Aparicio, Liliana Vásquez Ponce   +17 more
wiley   +1 more source

Raising Awareness: Real World Data On Palliative Care for Advanced Pediatric Cancers in Bavaria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Early integration of palliative care in children with cancer provides a variety of positive effects and is recommended at diagnosis. However, barriers often delay its implementation, and palliative care remains underutilized. This study provides real‐world data on palliative care and integration in pediatric oncology in a high ...
Nadja Nehls, Maja Börner, Sebastian Ziegelmayer, Bernhard Haller, Felicitas Ferrari‐von Klot, Markus Metzler, Michael C. Frühwald, Paul‐Gerhardt Schlegel, Selim Corbacioglu, Tobias Feuchtinger, Irene Teichert‐von Lüttichau   +10 more
wiley   +1 more source

The Problem of Molecular Target Choice for CAR-T Cells in Acute Myeloid Leukemia Therapy. [PDF]

Int J Mol Sci
Maiorova V, Mollaev MD, Vikhreva P, Kibardin A, Maschan MA, Larin SS.   +5 more
europepmc   +1 more source

Thiostrepton Suppresses the Progression of Rhabdomyosarcoma by Inhibiting the PI3K‐AKT Signaling Pathway

Pediatric Discovery, EarlyView.
The study establish TST as a multi‐mechanism PI3K‐AKT inhibitor for refractory RMS while validating Cmap‐driven drug repurposing for pediatric oncology. ABSTRACT Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma with 5‐year survival below 30% in high‐risk/metastatic cases, was investigated through integrated bioinformatics analysis (
Yu Wang, Peng Hong, Zhiqiang Gao, Wei Ma, Zaihong Hu, Jie Lin, Kongkong Cui, Qinlin Shi, Xiao‐Mao Tian, Guanghui Wei   +9 more
wiley   +1 more source

Acute myeloid leukemia: A rare cause of acquired isolated factor VII deficiency. [PDF]

Leuk Res Rep
Mlayah Z, Hafsa H, Ghorbel A, Slama N, Boukhris S, Laatiri MA.   +5 more
europepmc   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Recent advances of chimeric antigen receptor T-cell therapy for acute myeloid leukemia. [PDF]

Front Immunol
Liu Y, Wang W, Wang C, Deng J, Hu Y, Mei H, Luo S.   +6 more
europepmc   +1 more source

Push Forward Clinical Management of Hematological Toxicity due to Lenalidomide Overexposure: Model‐Informed Precision Dosing for Chinese Population With Renal Insufficiency

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Dose‐dependent hematological toxicity of lenalidomide has been reported previously, and thus, there is a clinical need for dose individualization to manage toxicities. The objectives of this study were to explore optimal individualized dosing regimens for Chinese B‐cell malignancies patients with varying degrees of renal function, and to push ...
Yi Ma, Zaiwei Song, Hao Bing, Huan He, Libo Zhao, Rongsheng Zhao   +5 more
wiley   +1 more source

Disease characteristics and monitoring of IDH1/IDH2-mutated acute myeloid leukemia. [PDF]

Blood Cancer J
Dantec M, Dufossé M, Boudry A, Fournier E, Goursaud L, Lebon D, Bories C, Plantier I, Tricot S, Daniel A, Willaume A, Coiteux V, Berthon C, Marolleau JP, Preudhomme C, Duployez N, Fenwarth L.   +16 more
europepmc   +1 more source