Myeloma protein kinetics following chemotherapy [PDF]
Blood, 1982 The effects of chemotherapy were evaluated in 43 multiple myeloma patients with high monoclonal globulin levels in both serum and urine. In responding patients, Bence Jones protein excretion declined more rapidly and markedly than the serum myeloma protein.
P McLaughlin, Raymond Alexanian
semanticscholar +6 more sources
PHYSICOCHEMICAL CHARACTERIZATION OF MOUSE MYELOMA PROTEINS: DEMONSTRATION OF HETEROGENEITY FOR EACH MYELOMA GLOBULIN [PDF]
The Journal of Experimental Medicine, 1961 Physicochemical characterization of mouse myeloma proteins revealed the individuality of each myeloma protein. When the myeloma proteins are considered collectively a wide range of individual properties were represented, including electrophoretic mobilities varying from the gamma to alpha region, hexose contents from 1 to 4 per cent, and ...
John L. Fahey
openalex +5 more sources
Cell-Bound Myeloma Proteins on the Surface of Myeloma Cells: Potential Targets for the Immune System [PDF]
Proceedings of the National Academy of Sciences, 1972 Rosette formation with 2,4,6-trinitrophenylated (Tnp)-sheep erythrocytes was used to demonstrate cell-bound myeloma proteins on cells from each of the eleven mouse plasmacytomas tested. Tnp-erythrocytes were bound directly by cells from two tumors (MOPC-315 and MOPC-460) that formed myeloma proteins with antihapten combining sites; rosette formation ...
Kristian Hannestad +2 more
openalex +5 more sources
A BALB/c Mouse IgA Myeloma Protein That Binds Salmonella Flagellar Protein [PDF]
Journal of Immunology, 1975 A BALB/c IgA mouse myeloma protein in ascites (MOPC-467) had been found to bind an antigen in heat extracts from Salmonella, Pasteurella, and Herellea cultures. MOPC-467 ascites was shown to immobilize motile S.
Alan Smith, M Potter
openalex +2 more sources
Studies on the localization of radiolabeled antibodies to a mouse myeloma protein [PDF]
Cancer, 1971 Arnold E. Reif
openalex +2 more sources
Nature Communications, 2022 The myeloma surface proteome (surfaceome) determines tumor interaction with the microenvironment and serves as an emerging arena for therapeutic development.
Ian D. Ferguson +28 more
semanticscholar +1 more source
Mechanisms of antigen escape from BCMA- or GPRC5D-targeted immunotherapies in multiple myeloma
Nature Network Boston, 2023 Tumor-intrinsic resistance mechanisms, including mutational events and immunoselection of mutant clones, were identified in 30 patients with multiple myeloma who experienced relapse after treatment with anti-BCMA CAR T cells and/or anti-BCMA bispecific T
Holly Lee +32 more
semanticscholar +1 more source
Multiple myeloma metabolism – a treasure trove of therapeutic targets?
Frontiers in Immunology, 2022 Multiple myeloma is an incurable cancer of plasma cells that is predominantly located in the bone marrow. Multiple myeloma cells are characterized by distinctive biological features that are intricately linked to their core function, the assembly and ...
Monica Roman-Trufero +3 more
doaj +1 more source
Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM
Nature Communications, 2021 Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains (LCs) but how post-translational modifications (PTMs) of LCs influence amyloid formation is not well understood.
Lynn Radamaker +17 more
doaj +1 more source
Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis
Nature Communications, 2021 Systemic AL amyloidosis is a protein misfolding disease caused by the aggregation and fibrillation of immunoglobulin light chains (LCs). Here, the authors present the cryo-EM structures of λ3 LC-derived amyloid fibrils that were isolated from patient ...
Lynn Radamaker +8 more
doaj +1 more source