Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy [PDF]
Case Reports in Gastrointestinal Medicine, 2021 Multiple myeloma is a type of plasma cell neoplasm that produces monoclonal immunoglobulin. Multiple myeloma is known to cause immunoglobulin light-chain (AL) amyloidosis, which frequently involves the kidney and heart.
Katsuya Endo +15 more
doaj +2 more sources
Myeloma protein kinetics following chemotherapy [PDF]
Blood, 1982 The effects of chemotherapy were evaluated in 43 multiple myeloma patients with high monoclonal globulin levels in both serum and urine. In responding patients, Bence Jones protein excretion declined more rapidly and markedly than the serum myeloma protein.
P, McLaughlin, R, Alexanian
openaire +4 more sources
Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma [PDF]
Cancer Research, 2016 Sergei Vatolin +16 more
openalex +2 more sources
Nature Communications, 2022 The myeloma surface proteome (surfaceome) determines tumor interaction with the microenvironment and serves as an emerging arena for therapeutic development.
Ian D. Ferguson +28 more
semanticscholar +1 more source
Multiple myeloma metabolism – a treasure trove of therapeutic targets?
Frontiers in Immunology, 2022 Multiple myeloma is an incurable cancer of plasma cells that is predominantly located in the bone marrow. Multiple myeloma cells are characterized by distinctive biological features that are intricately linked to their core function, the assembly and ...
Monica Roman-Trufero +3 more
doaj +1 more source
Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM
Nature Communications, 2021 Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains (LCs) but how post-translational modifications (PTMs) of LCs influence amyloid formation is not well understood.
Lynn Radamaker +17 more
doaj +1 more source
Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis
Nature Communications, 2021 Systemic AL amyloidosis is a protein misfolding disease caused by the aggregation and fibrillation of immunoglobulin light chains (LCs). Here, the authors present the cryo-EM structures of λ3 LC-derived amyloid fibrils that were isolated from patient ...
Lynn Radamaker +8 more
doaj +1 more source
Mechanisms of antigen escape from BCMA- or GPRC5D-targeted immunotherapies in multiple myeloma
Nature Medicine, 2023 Tumor-intrinsic resistance mechanisms, including mutational events and immunoselection of mutant clones, were identified in 30 patients with multiple myeloma who experienced relapse after treatment with anti-BCMA CAR T cells and/or anti-BCMA bispecific T
Holly Lee +32 more
semanticscholar +1 more source
Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma.
New England Journal of Medicine, 2022 BACKGROUND G protein-coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor expressed in malignant plasma cells. Talquetamab, a bispecific antibody against CD3 and GPRC5D, redirects T cells to mediate killing of GPRC5D-expressing ...
A. Chari +19 more
semanticscholar +1 more source
Blood, 2020 T cell-mediated approaches have shown promise in myeloma treatment. However, there are currently a limited number of specific myeloma antigens that can be targeted, and MM remains an incurable disease. G-protein coupled receptor class 5 member D (GPRC5D)
K. Pillarisetti +18 more
semanticscholar +1 more source