Results 131 to 140 of about 5,838,181 (363)

Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma.

Blood, 2017
M. McDonald, M. McDonald, M. Reagan, M. Reagan, Scott E. Youlten, Scott E. Youlten, Sindhu T. Mohanty, A. Seckinger, Rachael L. Terry, Rachael L. Terry, J. Pettitt, Marija K Simic, T. Cheng, A. Morse, Lawrence M T Le, David Abi-Hanna, David Abi-Hanna, I. Kramer, C. Falank, H. Fairfield, I. Ghobrial, P. Baldock, P. Baldock, D. Little, M. Kneissel, K. Vanderkerken, J. Bassett, G. Williams, B. Oyajobi, D. Hose, Tri Giang Phan, Tri Giang Phan, P. Croucher, P. Croucher   +33 more
semanticscholar   +1 more source

Dysregulated Immune Proteins in Plasma in the UK Biobank Predict Multiple Myeloma 12 years Before Clinical Diagnosis [PDF]

Joshua Fieggen, Anshul Thakur, Christopher Butler, Karthik Ramasamy, Anjan Thakurta, David A. Clifton, Lei Clifton   +6 more
openalex   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

HETEROGENEITY OF MYELOMA PROTEINS [PDF]

Journal of Clinical Investigation, 1963
openaire   +2 more sources

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

A Case of Combined POEMS Syndrome and Multiple Myeloma with Positive M protein Only on Immunofixation [PDF]

, 2008
Jae Hoon Yang, Joo Young Jung, Chan-Soo So, Yu Jin Lim, Seung-Yong Han, Sarah Park, Jung Han Kim, Mina Hur, Gyung Kyu Lee, Jung‐Weon Shim, Young Iee Park   +10 more
openalex   +1 more source

Supplementary Video 3 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

, 2023
Shuang Chen, Yun Dai, Xin‐Yan Pei, Jennifer S. Myers, Li Wang, Lora B. Kramer, Mandy Garnett, Daniella M. Schwartz, Florence Su, Gary Simmons, Justin D. Richey, Dustin G. Larsen, Paul Dent, Robert Z. Orlowski, Steven Grant   +14 more
openalex   +1 more source

Supplementary Materials and Methods from Protein Kinase CK2 Protects Multiple Myeloma Cells from ER Stress–Induced Apoptosis and from the Cytotoxic Effect of HSP90 Inhibition through Regulation of the Unfolded Protein Response [PDF]

, 2023
Sabrina Manni, Alessandra Brancalion, Laura Quotti Tubi, Anna Colpo, Laura Pavan, Anna Cabrelle, Elisa Ave, Fortunato Zaffino, Giovanni Di Maira, Maria Ruzzene, Fernando Adami, Renato Zambello, Maria Rita Pitari, Pierfrancesco Tassone, Lorenzo A. Pinna, Carmela Gurrieri, Gianpietro Semenzato, Francesco Piazza   +17 more
openalex   +1 more source

The effect of non‐surgical periodontal treatment on Dickkopf‐1 and secreted Frizzled‐Related Protein 5 levels

Journal of Periodontology, EarlyView.
Abstract Background Recent advancements in bone tissue biomarker research have identified 2 promising molecules: Dickkopf‐1 and secreted Frizzled‐Related Protein 5. This study aims to evaluate the levels of these biomarkers in gingival crevicular fluid in periodontal health, gingivitis, and periodontitis and to assess the effects of non‐surgical ...
Sukran Acipinar, Kubilay Baris
wiley   +1 more source

Inhibition of Myeloma Cell Function by Cannabinoid-Enriched Product Associated With Regulation of Telomere and TP53

Integrative Cancer Therapies
Multiple myeloma is a hematological cancer caused by the uncontrolled proliferation of abnormal plasma cells in the bone marrow, leading to excessive immunoglobulin production. Our study aimed to examine the anticancer properties of BRF1A, a cannabinoid (
Ibrahim Musa PhD, Nan Yang PhD, Joseph Breslin PhD, Orion Paulden, Jan Geliebter PhD, Raj Tiwari PhD, Xiu-Min Li MD, MS, MPH   +6 more
doaj   +1 more source