Results 141 to 150 of about 5,838,181 (363)

The role of bone morphogenetic proteins in myeloma cell survival [PDF]

, 2014
Toril Holien, Anders Sundan
openalex   +1 more source

The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma

Molecular Cancer Therapeutics, 2017
R. Le Moigne, B. Aftab, S. Djakovic, Eugen Dhimolea, E. Valle, M. Murnane, E. King, F. Soriano, M. Menon, Zhiheng Wu, Steve T. Wong, Grace J. Lee, B. Yao, Arun P. Wiita, C. Lam, J. Rice, Jinhai Wang, M. Chesi, P. Bergsagel, M. Kraus, C. Driessen, Szerenke Kiss von Soly, F. Yakes, D. Wustrow, L. Shawver, Han-Jie Zhou, T. Martin, J. Wolf, C. Mitsiades, Daniel J. Anderson, M. Rolfe   +30 more
semanticscholar   +1 more source

A Refractory Leg Skin Ulcer Associated With Multiple Myeloma Successfully Treated With Plasma Exchange, Lenalidomide, and Dexamethasone

JEADV Clinical Practice, EarlyView.
ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder that primarily presents with CRAB symptoms (calcium elevation, renal failure, anemia, and bone abnormalities). In rare cases, MM manifests with systemic complications like skin ulcers, which present management challenges. Here, we report a 78‐year‐old Japanese man with MM and refractory
Naoko Hattori, Yutaka Kuwatsuka, Tomoka Waseda, Daisuke Ehara, Koji Ando, Hiroyuki Murota   +5 more
wiley   +1 more source

B-371 Two Cases of Multiple Myeloma Achieving Complete Remission But Presenting Residual M-protein by the EXENT® Solution [PDF]

, 2023
Oscar Berlanga, Jane Birtwistle, Sariah J. Allen, Gill Malin, Gabriella Lakos   +4 more
openalex   +1 more source

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

Evaluation of serum glucose-regulated protein 78 (GRP78) as a biomarker of treatment response to bortezomib-based induction regimen in multiple myeloma: A cross-sectional pilot study

, 2022
Suganthi S. Ramachandran, Pooja Gupta, Lalit Kumar, Ritu Gupta, Lavisha Goel, Vijay Lakshmi KUMAR, Yogendra Kumar Gupta   +6 more
openalex   +2 more sources

C-reactive protein promotes bone destruction in human myeloma through the CD32–p38 MAPK–Twist axis

Science Signaling, 2017
Jing Yang, Zhiqiang Liu, Huan Liu, Jin He, J. Yang, P. Lin, Qiang Wang, J. Du, Wencai Ma, Zheng Yin, E. Davis, R. Orlowski, J. Hou, Q. Yi   +13 more
semanticscholar   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Wnt inhibitors reduce the unfolded protein response and enhance bortezomib-induced cell death in multiple myeloma [PDF]

, 2022
Ingrid Spaan, Niels van Nieuwenhuijzen, Thomas Kimman, Dedeke Rockx-Brouwer, Ralph G. Tieland, Madelon M. Maurice, Monique C. Minnema, Reinier Raymakers, Victor Peperzak   +8 more
openalex   +1 more source