Results 181 to 190 of about 5,838,181 (363)

IRF4 Enhances Radiosensitivity of Cervical Cancer by Inhibiting the PI3K/Akt/mTOR Pathway to Regulate Autophagy

open access: yesCancer Science, EarlyView.
IRF4 is a prognostic biomarker in cervical cancer. IRF4 enhances radiosensitivity and inhibits tumor growth via PI3K/AKT/mTOR‐mediated autophagy. IRF4 boosts radiation response in vitro and in vivo. ABSTRACT Interferon regulatory factor 4 (IRF4), a critical member of the IRF transcription factor family, harbors an elusive biological role in cervical ...
Meihui Gao   +9 more
wiley   +1 more source

Navigating the evolving management of smoldering multiple myeloma. [PDF]

open access: yesHemasphere
Hammami MB   +6 more
europepmc   +1 more source

Label-free protein-structure-sensitive live-cell microscopy for patient-specific assessment of myeloma therapy [PDF]

open access: hybrid
Francesca Gasparin   +10 more
openalex   +1 more source

Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer

open access: yesCancer Science, EarlyView.
The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Toshiki Oka   +26 more
wiley   +1 more source

Affinity labeling of the heavy and light chains of a myeloma protein with anti-2,4-dinitrophenyl activity.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1970
J. Haimovich, D. Givol, H. Eisen
semanticscholar   +1 more source

LncRNA H19‐Encoded Micropeptide altH19 Promotes DNA Replication and Mitosis in Myeloma Cells by Enhancing the Phosphorylation of CDK2 at Threonine 160

open access: yesCell Proliferation, EarlyView.
The micropeptide altH19 interacts with phosphorylated CDK2 (p‐CDK2), subsequently activating CDK2 phosphorylation. This enhances the downstream E2F1 target gene RB activity, which accelerates DNA replication, ultimately leading to rapid myeloma cell mitosis and proliferation.
Yaxin Zhang   +6 more
wiley   +1 more source

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