Results 11 to 20 of about 5,838,181 (363)
From Polyuria to Pathological Fracture: A Challenging Case of Multiple Myeloma
Liječnički vjesnik, 2023 Multiple myeloma is a proliferation of neoplastic plasma cells producing a monoclonal protein (M-protein). Multiple myeloma can present in various ways with anemia, renal failure, hypercalcemia, and bone fractures as the most common signs.
Lucija Galiot, Zdravko Mitrović
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Cancer Research, 2020 This study identifies a new multiple myeloma–specific tumor suppressor complex that regulates autophagy and unconventional secretion, highlighting the sensitivity of multiple myeloma cells to the accumulation of protein aggregates Multiple myeloma is a ...
N. Manfrini +18 more
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Hematology, 2023 Background: BCL2-interacting protein 3 (BNIP3) expression varies among cancers, and its role in myeloma cells remains unknown. We investigated the role of BNIP3 overexpression in myeloma cells, and particularly its effects on apoptosis and mitochondria ...
Pingping Xiao +7 more
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Advanced Medical Journal, 2022 Background and objectives: Multiple Myeloma is a clonal plasma cell proliferation in the bone marrow that produces abnormal monoclonal proteins in serum and /or urine that leads to end-organ damage. We aimed to evaluate concentration, type of monoclonal
Ahmed Khudair Yassin +22 more
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Myeloma Proteins, Bence Jones Proteins and Normal Immunoglobulins in Multiple Myeloma [PDF]
Blood, 1967 Abstract The relationship between the anomalous and normal immunoglobulins was studied through measurement of myeloma protein (MP), Bence Jones protein (BJP), and the normal γG, γA, γM and γD-globulin levels in a large group of patients with multiple myeloma. These determinations were made prior to and after initiation of three different
V, Caggiano, J, Cuttner, A, Solomon
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GPRC5D-Targeted CAR T Cells for Myeloma.
New England Journal of Medicine, 2022 BACKGROUND B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapies have generated responses in patients with advanced myeloma, but relapses are common. G protein-coupled receptor, class C, group 5, member D (GPRC5D) has
S. Mailankody +37 more
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Epidemiology, Staging, and Management of Multiple Myeloma
Medical Science, 2021 Multiple myeloma (MM) is a plasma cell disorder that is on the rise throughout the world, especially in the US, Australia, and Western Europe. In the US, MM accounts for almost 2% of cancer diagnoses and over 2% of cancer deaths (more than double the ...
S. Padala +7 more
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Technology in Cancer Research & Treatment, 2020 Objective: The present study aimed to explore the correlation of protein kinase D 1 with prognosis in bortezomib-treated multiple myeloma patients and further investigate the effect of protein kinase D 1 knockdown on drug sensitivity to bortezomib in ...
Xuesong Li MM, Ying Yang MM, Xue Yi MM
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Technology in Cancer Research & Treatment, 2020 Objective: The present study aimed to detect A-kinase interacting protein 1 expression and further explore the association of A-kinase interacting protein 1 with clinical features and prognosis in patients with multiple myeloma.
Wei Wang MD +4 more
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Blood, 2019 Three proteasome inhibitors have garnered regulatory approvals in various multiple myeloma settings; but drug resistance is an emerging challenge, prompting interest in blocking upstream components of the ubiquitin-proteasome pathway. One such attractive
J. Zhuang +18 more
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