Results 11 to 20 of about 5,782,005 (384)

Structure-function relations in phosphorylcholine-binding mouse myeloma proteins. [PDF]

, 1977
The binding site interactions between the phosphorylcholine (phosphocholine)-binding mouse myeloma proteins TEPC 15, W3207, McPC 603, MOPC 167, and MOPC 511 and the isotopically substituted hapten phosphoryl-[methyl-13C]choline have been investigated ...
Andrew M. Goetze, John H. Richards
openalex   +4 more sources

Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma.

New England Journal of Medicine, 2022
BACKGROUND G protein-coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor expressed in malignant plasma cells. Talquetamab, a bispecific antibody against CD3 and GPRC5D, redirects T cells to mediate killing of GPRC5D-expressing ...
A. Chari, M. Minnema, J. Berdeja, A. Oriol, N. V. D. van de Donk, P. Rodríguez-Otero, E. Askari, M. Mateos, L. Costa, J. Caers, R. Verona, S. Girgis, Shiyi Yang, R. Goldsmith, Xiang Yao, K. Pillarisetti, B. Hilder, Jeffery Russell, J. Goldberg, A. Krishnan   +19 more
semanticscholar   +1 more source

From Polyuria to Pathological Fracture: A Challenging Case of Multiple Myeloma

Liječnički vjesnik, 2023
Multiple myeloma is a proliferation of neoplastic plasma cells producing a monoclonal protein (M-protein). Multiple myeloma can present in various ways with anemia, renal failure, hypercalcemia, and bone fractures as the most common signs.
Lucija Galiot, Zdravko Mitrović
doaj   +1 more source

Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy

Case Reports in Gastrointestinal Medicine, 2021
Multiple myeloma is a type of plasma cell neoplasm that produces monoclonal immunoglobulin. Multiple myeloma is known to cause immunoglobulin light-chain (AL) amyloidosis, which frequently involves the kidney and heart.
Katsuya Endo, Takehito Ito, Jun Nomura, Keigo Murakami, Shiho Kondo, Tomonori Satoh, Daisuke Fukushi, Yuki Yoshino, Yoshiteru Sasaki, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Takayoshi Meguro, Kazuhiro Murakami, Junichi Kameoka, Kennichi Satoh   +15 more
doaj   +1 more source

BNIP3 overexpression may promote myeloma cell apoptosis by enhancing sensitivity to bortezomib via the p38 MAPK pathway

Hematology, 2023
Background: BCL2-interacting protein 3 (BNIP3) expression varies among cancers, and its role in myeloma cells remains unknown. We investigated the role of BNIP3 overexpression in myeloma cells, and particularly its effects on apoptosis and mitochondria ...
Pingping Xiao, Xuyan Chen, Zhigao Dong, Wei Fan, Yongquan Chen, Junnan Su, Qingqing Wang, Lili Ma   +7 more
doaj   +1 more source

A T CELL REDIRECTING BISPECIFIC G-PROTEIN COUPLED RECEPTOR CLASS 5 MEMBER DxCD3 ANTIBODY TO TREAT MULTIPLE MYELOMA.

Blood, 2020
T cell-mediated approaches have shown promise in myeloma treatment. However, there are currently a limited number of specific myeloma antigens that can be targeted, and MM remains an incurable disease. G-protein coupled receptor class 5 member D (GPRC5D)
K. Pillarisetti, S. Edavettal, M. Mendonca, Yingzhe Li, M. Tornetta, A. Babich, Nate Majewski, Matt Husovsky, D. Reeves, Eileen Walsh, Diana Chin, L. Luistro, J. Joseph, Gerald C. Chu, K. Packman, Shoba Shetty, Y. Elsayed, R. Attar, F. Gaudet   +18 more
semanticscholar   +1 more source

Myeloma Proteins, Bence Jones Proteins and Normal Immunoglobulins in Multiple Myeloma [PDF]

Blood, 1967
Abstract The relationship between the anomalous and normal immunoglobulins was studied through measurement of myeloma protein (MP), Bence Jones protein (BJP), and the normal γG, γA, γM and γD-globulin levels in a large group of patients with multiple myeloma. These determinations were made prior to and after initiation of three different
Vincent Caggiano, Vincent Caggiano, Alan Solomon, Janet Cuttner   +3 more
openaire   +3 more sources

FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy

Cancer Research, 2020
This study identifies a new multiple myeloma–specific tumor suppressor complex that regulates autophagy and unconventional secretion, highlighting the sensitivity of multiple myeloma cells to the accumulation of protein aggregates Multiple myeloma is a ...
N. Manfrini, Marilena Mancino, A. Miluzio, S. Oliveto, Matteo Balestra, Piera Calamita, R. Alfieri, R. Rossi, M. Sassoè-Pognetto, C. Salio, A. Cuomo, T. Bonaldi, M. Manfredi, E. Marengo, E. Ranzato, S. Martinotti, Davide Cittaro, G. Tonon, S. Biffo   +18 more
semanticscholar   +1 more source

GPRC5D-Targeted CAR T Cells for Myeloma.

New England Journal of Medicine, 2022
BACKGROUND B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapies have generated responses in patients with advanced myeloma, but relapses are common. G protein-coupled receptor, class C, group 5, member D (GPRC5D) has
S. Mailankody, Sean M. Devlin, Jonathan Landa, Karthik Nath, C. Diamonte, Elizabeth J Carstens, Douglas Russo, Romany Auclair, Lisa Fitzgerald, Briana Cadzin, Xiuyan Wang, D. Sikder, B. Senechal, Vladimir P Bermudez, Terence J. Purdon, K. Hosszu, D. McAvoy, Tasmin Farzana, E. Mead, Jessica A Wilcox, B. Santomasso, G. Shah, U. Shah, N. Korde, A. Lesokhin, C. Tan, M. Hultcrantz, H. Hassoun, M. Roshal, Filiz Sen, Ahmet Dogan, O. Landgren, S. Giralt, Jae H. Park, S. Usmani, I. Rivière, R. Brentjens, Eric L Smith   +37 more
semanticscholar   +1 more source

The concentration and type of monoclonal protein and their impact on clinical severity in patients with symptomatic myeloma

Advanced Medical Journal, 2022
Background and objectives: Multiple Myeloma is a clonal plasma cell proliferation in the bone marrow that produces abnormal monoclonal proteins in serum and /or urine that leads to end-organ damage. We aimed to evaluate concentration, type of monoclonal
Ahmed Khudair Yassin, Najmaddin Salih Husen Khsohnaw, Sana Dlawar Jalal, Akram Mahmood Mohammed, Kawa Mohamedamin Hasan , Dana Ahmed Abdulla, Ameer Badi, Banaz Mubarak Safar, Basil Kadhim Abdulla, Rawand Polus Shamoon, Diveen Jalal Hussein, Nawsherwan Sadiq Mohammed, Kanar Jalal Karim, Abid Mohiaddin Hassen, Hisham Arf Getta, Rezhin Nawzad Rajab, Friad Hiwaizi Hiwaizi, Truska Awat Amin, Zeki Ali Mohamed, Ali Ibrahim Mohammed, Hameed Saeed, Parween Ismael, Alaa Alwan   +22 more
doaj   +1 more source