Results 21 to 30 of about 5,838,181 (363)

Protein Targeting Chimeric Molecules Specific for Bromodomain and Extra-terminal Motif Family Proteins are Active Against Pre-Clinical Models of Multiple Myeloma

Leukemia, 2018
Bromodomain and extraterminal (BET) domain containing protein (BRD)-4 modulates the expression of oncogenes such as c-myc, and is a promising therapeutic target in diverse cancer types.
Xiaohui Zhang, Xiaohui Zhang, Hans C. Lee, F. Shirazi, V. Baladandayuthapani, Heather C. Lin, I. Kuiatse, Hua Wang, R. J. Jones, Z. Berková, Ram K. Singh, Jing Lu, Y. Qian, Kanak Raina, K. Coleman, C. Crews, Bingzong Li, H. Wang, Y. Hailemichael, S. Thomas, Zhiqiang Wang, R. Davis, R. Orlowski   +22 more
semanticscholar   +1 more source

Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis

Nature Communications, 2019
Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains and is one of the most frequently occurring forms of systemic amyloidosis.
Lynn Radamaker, Yin-Hsi Lin, Karthikeyan Annamalai, Stefanie Huhn, Ute Hegenbart, Stefan O. Schönland, Günter Fritz, Matthias Schmidt, Marcus Fändrich   +8 more
doaj   +1 more source

PINK1‐Dependent Mitophagy Regulates the Migration and Homing of Multiple Myeloma Cells via the MOB1B‐Mediated Hippo‐YAP/TAZ Pathway

Advanced Science, 2020
The roles of mitochondrial dysfunction in carcinogenesis remain largely unknown. The effects of PTEN‐induced putative kinase 1 (PINK1)‐dependent mitophagy on the pathogenesis of multiple myeloma (MM) are determined.
Shengjun Fan, Trevor Price, Wei Huang, Michelle Plue, Jonathan Warren, Pasupathi Sundaramoorthy, Barry Paul, Daniel Feinberg, Nancie MacIver, Nelson Chao, Dorothy Sipkins, Yubin Kang   +11 more
doaj   +1 more source

Chronic pain in the thoracic spine as a symptom of multiple myeloma - case report

Journal of Education, Health and Sport, 2017
Multiple myeloma is a hematological cancer, characterized by the neoplastic proliferation of a single clone of plasma cell producing a monoclonal protein. The incidence of multiple myeloma increases with age. The median age ad diagnosis is between 63 and
Kamila Woźniak, Dorota Ratuszek-Sadowska, Mateusz Szostak, Agnieszka Nowacka, Maciej Śniegocki   +4 more
doaj   +3 more sources

Multiple myeloma (pathogenesis, clinical features, diagnosis, differential diagnosis). Part I

Клиническая онкогематология, 2013
Multiple myeloma (MM) is a malignancy characterized by bone marrow infiltration with plasma cell and extensive skeletal bone destruction resulting in bone pain and fractures.
S. S. Bessmeltsev
doaj   +1 more source

Anti-BCMA Immunotoxins: Design, Production, and Preclinical Evaluation

Biomolecules, 2020
Multiple myeloma (MM) is a B-cell malignancy that is incurable for a majority of patients. B-cell maturation antigen (BCMA) is a lineage-restricted differentiation protein highly expressed in multiple myeloma cells but not in other normal tissues except ...
Tapan K. Bera
doaj   +1 more source

Association of Myeloma in Patients of Chronic Kidney Disease; A Single Centered Study

Journal of Bahria University Medical and Dental College, 2023
Objective: To evaluate the frequency along with socio-demographic factors and clinical features of myeloma in patients with chronic kidney disease (CKD) presenting at a tertiary care hospital in Karachi, Pakistan.
Farzana Adnan Sheikh, Syed Tajammul Ali, Sidra Rashid, Mehwish Qamar, Khadijah Abid   +4 more
doaj   +1 more source

Retrospective evaluation of the use of the International Myeloma Working Group response criteria in dogs with secretory multiple myeloma

Journal of Veterinary Internal Medicine, 2021
Background Current recommendations for monitoring disease progression and response to treatment in humans with multiple myeloma include evaluation of serum paraprotein (M‐protein) concentration. Densitometry, species‐specific radial immunodiffusion (RID)
A Russell Moore, Adam Harris, Christina Jeffries, Paul R. Avery, Kate Vickery   +4 more
doaj   +1 more source

Extracellular matrix protein Reelin promotes myeloma progression by facilitating tumor cell proliferation and glycolysis

Scientific Reports, 2017
Reelin is an extracellular matrix protein that is crucial for neuron migration, adhesion, and positioning. We examined the expression of Reelin in a large cohort of multiple myeloma patients recorded in Gene Expression Omnibus (GEO) database and used ...
Xiaodan Qin, Liang Lin, Li-zhen Cao, Xinwei Zhang, Xiao Song, Jie Hao, Yan Zhang, Risheng Wei, Xiaojun Huang, Jin Lu, Q. Ge   +10 more
semanticscholar   +1 more source

IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma

Scientific Reports, 2023
Previous studies have shown the potential of immunogenic cell death-related modalities in myeloma. The significance of IL5RA in myeloma and immunogenic cell death remains unknown.
Cong Xu, Meng Gao, Junhua Zhang, Yunfeng Fu   +3 more
doaj   +1 more source