Results 331 to 340 of about 5,782,005 (384)

Vaccination in Multiple Myeloma: Challenges and Strategies

European Journal of Haematology, EarlyView.
ABSTRACT Background Multiple myeloma (MM) is a hematological malignancy characterized by profound immunosuppression resulting from both disease‐related mechanisms and treatment‐induced immune dysfunction. This compromised immune status markedly increases susceptibility to infections, a leading cause of morbidity and mortality in MM patients.
Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Santino Caserta, Francesco Mendicino, Fortunato Morabito, Massimo Gentile   +10 more
wiley   +1 more source

A Rare Type of Myeloma: A Case of Monoclonal IgD-Lambda. [PDF]

Cureus
Kaya R, Kocabıyık AB, Kurtoğlu E, Karakuş V.   +3 more
europepmc   +1 more source

Physical and functional interactions between LDLR family members and CXCR4 in breast cancer

The FEBS Journal, EarlyView.
Here, we demonstrate that members of the low‐density lipoprotein receptor (LDLR) family can regulate C‐X‐C chemokine receptor type 4 (CXCR4) signaling and therefore affect CXCR4‐induced breast cancer metastasis. We found that very low‐density lipoprotein receptor (VLDLR), low‐density lipoprotein receptor‐related protein 8 (LRP8) and apolipoprotein E ...
Jiankang Zhang, Jinxiao Chen, Da Wo, En Ma, Hongwei Yan, Jun Peng, Dan‐ni Ren, Weidong Zhu   +7 more
wiley   +1 more source

Prognostic and diagnostic value of PVR gene and protein levels, serum amylase, and urinary IGFBP-7 and TIMP-2 biomarkers in multiple myeloma. [PDF]

BMC Cancer
Habib EM, Hasan AM, Mohammed SAA, Othman AAA, Elgamal R, Sherief DE.   +5 more
europepmc   +1 more source

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

The FEBS Journal, EarlyView.
Multiple myeloma is characterised by the clonal proliferation of plasma cells in the bone marrow. Extracellular vesicles (EVs) are a key component of cell‐to‐cell communication within the bone marrow microenvironment, promoting tumour growth, bone remodelling, immune modulation, angiogenesis and therapeutic resistance.
Chloe Wylie, Rebecca Rowan, Dessi Malinova, Lisa Crawford   +3 more
wiley   +1 more source

Quantification of Total and Unbound Selinexor Concentrations in Human Plasma by a Fully Validated Liquid Chromatography-Tandem Mass Spectrometry Method. [PDF]

Pharmaceutics
Lee S, Yang S, Kim H, Shim WS, Song E, Han S, Park SS, Choi S, Han S, Joo SH, Park SJ, Shin B, Kim D, Kim HS, Lee KT, Chung EK.   +15 more
europepmc   +1 more source

TENT5C functions as a corepressor in the ligand‐bound glucocorticoid receptor and estrogen receptor α complexes

The FEBS Journal, EarlyView.
TENT5C is a suppressor of ERα and GR transcriptional activation. A specific LXXLL motif in TENT5C, absent in the other members of the TENT5 subfamily, mediates a stable interaction with the Ligand Binding Domain of ERα but not with that of GR.
Yin Li, Lalith Perera, Rebecca S. He, Marine Baptissart, Robert M. Petrovich, Marcos Morgan   +5 more
wiley   +1 more source

Stage-specific gene pair ratios highlight genes and mechanisms related to presymptomatic and symptomatic Multiple Myeloma. [PDF]

Comput Struct Biotechnol J
Georgiou G, Minadakis G, Karathanasis N, Savva K, Athieniti E, Bourdakou MM, Spyrou GM.   +6 more
europepmc   +1 more source

Potential cytotoxicity of truncated slow skeletal muscle troponin T (ssTnT) in a loss of function TNNT1 myopathy mouse model

The FEBS Journal, EarlyView.
A loss of function TNNT1 myopathy mouse model with the nonsense mutation p.E180* showed potential cytotoxicity of the truncated slow troponin T fragment. The mRNA expression profile in the soleus muscle of Tnnt1‐p.E180* mice showed very different changes in comparison to that of Tnnt1‐knockout mice.
Han‐Zhong Feng, Kevin A. Strauss, Jian‐Ping Jin   +2 more
wiley   +1 more source

Immunosuppressive Effects of Multiple Myeloma-Derived Extracellular Vesicles Through T Cell Exhaustion. [PDF]

Cancer Sci
Hagiwara S, Ri M, Ebina T, Marumo Y, Nakamura T, Hirade K, Nakashima T, Asano A, Kinoshita S, Suzuki T, Narita T, Masaki A, Komatsu H, Iida S.   +13 more
europepmc   +1 more source