Results 51 to 60 of about 5,782,005 (384)
Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease [PDF]
, 2020 The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
Li, Jing, Sherman, David J.
core
"Myeloma Protein" in a Patient with Monocytic Leukemia [PDF]
Blood, 1969 Abstract A 74 year old man with monocytic leukemia was found to have serum and urinary protein findings typical of myelomatosis. Lysozyme excretion in the urine was in the range characteristic of monocytic leukemia. There were no x-ray findings indicative of myeloma.
Lawrence Berman +2 more
openaire +3 more sources
The non-coding RNA landscape of plasma cell dyscrasias [PDF]
, 2020 Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat.
Azab, Kareem A +3 more
core +1 more source
Gene Co-expression Network and Copy Number Variation Analyses Identify Transcription Factors Associated With Multiple Myeloma Progression [PDF]
, 2019 Multiple myeloma (MM) has two clinical precursor stages of disease: monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). However, the mechanism of progression is not well understood.
Abu Zaid, Mohammad +7 more
core +5 more sources
CPT: Pharmacometrics & Systems Pharmacology, 2019 The heterogeneous polyclonal nature of multiple myeloma complicates the identification of protein biomarkers predictive of drug response. In this study, a pharmacodynamic systems modeling approach was used to link in vitro bortezomib exposure and myeloma
Vidya Ramakrishnan, Donald E. Mager
doaj +1 more source
A Rare Case of Multiple Myeloma with Biclonal Gammopathy [PDF]
Journal of Clinical and Diagnostic Research, 2016 Multiple myeloma is a debilitating malignancy arising from plasma cells. These malignant plasma cells called myeloma cells proliferate and infiltrate the bone marrow.
Abhik Banerjee +2 more
doaj +1 more source
Preclinical evidence of a direct pro-survival role of arginine deprivation in multiple myeloma
Frontiers in Oncology, 2022 Multiple myeloma grows by establishing multiple interactions with bone marrow cells. These include expansion of myeloid-derived suppressor cells, which drive immunoevasion via mechanisms that include arginase-1-driven depletion of L-arginine, thus ...
Matteo Trudu +11 more
doaj +1 more source
Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
core +1 more source
DangER: protein ovERload. Targeting protein degradation to treat myeloma
Haematologica, 2012 Myeloma is a malignancy of the antibody-producing plasma cells and, as such, these cells synthesize large quantities of unfolded or misfolded immunoglobulin.
Lauren I. Aronson, Faith E. Davies
doaj +1 more source
IMMUNOLOGICAL RELATIONSHIPS AMONG THE MYELOMA PROTEINS [PDF]
The Journal of Experimental Medicine, 1955 An immunological study of 21 myeloma sera was carried out to determine their relationship to components of normal γ-globulin and to each other. Ten proteins were separated for detailed characterization. Every one of the myeloma proteins studied was immunologically different, indicating individual specificity.
S. M. Ward +2 more
openaire +3 more sources