Results 61 to 70 of about 5,838,181 (363)

TAZ upregulates MIR‐224 to inhibit oxidative stress response in multiple myeloma

Cancer Reports, 2023
Background Oxidative stress within the bone marrow niche of multiple myeloma contributes to disease progression and drug resistance. Recent studies have associated the Hippo pathway with miRNA biogenesis and oxidative stress in solid tumors.
Samuel O. Abegunde, Stacy Grieve, Tony Reiman   +2 more
doaj   +1 more source

Expression of p53 protein isoforms predicts survival in patients with multiple myeloma [PDF]

, 2022
Elizabeta A. Rojas, Luís A. Corchete, Cristina De Ramón, Patryk Krzemiński, Dalia Quwaider, Ramón García‐Sánz, Joaquín Martínez‐López, Albert Oriol, Laura Rosiñol, Joan Bladé, Juan José Lahuerta, Jesús F. San Miguel, Marcos González, María‐Victoria Mateos, Jean‐Christophe Bourdon, Irena Misiewicz-Krzemińska, Norma C. Gutiérrez   +16 more
openalex   +1 more source

Daratumumab Treatment for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated neuropathy featuring progressive weakness, sensory deficits, and areflexia. While corticosteroids, intravenous immunoglobulin, and plasmapheresis are effective first‐line immunotherapies, a subset of patients remains treatment‐refractory.
Xueyu Zhang, Jianli Zhao, Xue Zhao, Xiaowei Hu, Zichun Xiao, Jie Wu, Xiaowen Li, Jing Xu, Yu‐Jing Li   +8 more
wiley   +1 more source

Combined Proteasome and Autophagy Inhibition in Relapsed/Refractory Multiple Myeloma—A Phase I Trial of Hydroxychloroquine, Carfilzomib, and Dexamethasone

eJHaem
Multiple myeloma is characterized by malignant cells which produce high amounts of monoclonal immunoglobulin. Myeloma cells are, therefore, dependent on effective protein degradation.
Tobias S. Slørdahl, Frida Bugge Askeland, Margrete Sofie Sætre Hanssen, Håkon Hov, Stine Marie Sundt‐Hansen, Sofia Lindahl, Nils Tore Vethe, Henrik Hjorth‐Hansen, Mona H. Fenstad, Anders Waage, Øyvind Hjertner, Fredrik Schjesvold, Anders Sundan   +12 more
doaj   +1 more source

Impact of XIAP protein levels on the survival of myeloma cells

Haematologica, 2009
Background XIAP is the best characterized and the most potent direct endogenous caspase inhibitor and is considered a key actor in the control of apoptotic threshold in cancer cells.
Grégoire Desplanques, Nicola Giuliani, Roberto Delsignore, Vittorio Rizzoli, Régis Bataille, Sophie Barillé-Nion   +5 more
doaj   +1 more source

Monitoring the M-protein of multiple myeloma patients treated with a combination of monoclonal antibodies: the laboratory solution to eliminate interference [PDF]

, 2021
Somayya Noori, Christie P.M. Verkleij, Marina Zajec, Pieter Langerhorst, Patricia W.C. Bosman, Yolanda B. de Rijke, Sonja Zweegman, Martijn M. VanDuijn, Theo M. Luider, Niels W.C.J. van de Donk, Joannes F.M. Jacobs   +10 more
openalex   +1 more source

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

THE FORMATION OF MYELOMA PROTEIN BY A MOUSE PLASMA CELL TUMOR

Journal of Experimental Medicine, 1958
The origin of the myeloma protein found in mice bearing the plasma cell tumor X5563 has been investigated. Specific activity-time curves of the myeloma proteins isolated from the tumor and from the plasma of these animals were compared following ...
D. Nathans, J. Fahey, M. Potter
semanticscholar   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
ABSTRACT Multiple myeloma (MM) is a hematologic malignancy driven by clonal expansion of malignant plasma cells. Despite the long‐term disease control achieved with immunotherapies in some patients, treatment resistance remains a major cause of disease relapse.
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source