Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma [PDF]
, 2012 Copyright @ 2013 Macmillan Publishers Limited. This is the author's accepted manuscript. The final published article is available from the link below.Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM).
A Barbarulo +63 more
core +2 more sources
A Case Report of Atypical Presentation of Multiple Myeloma on Serum Protein Electrophoresis [PDF]
Journal of Krishna Institute of Medical Sciences University, 2018 Multiple myeloma is a group of B-cell disorders resulting in the secretion of a specific and unique monoclonal immunoglobulin (M-protein). Protein electrophoresis is advised whenever multiple myeloma is suspected.
Pooja P. Padasal, Anil Malleshappa
doaj
GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells
Science Translational Medicine, 2019 GPRC5D is an attractive target for immunotherapy of myeloma, and optimized GPRC5D-targeted CAR T cells eradicate myeloma xenografts. CARs to drive away multiple myeloma Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have ...
Eric L. Smith +25 more
semanticscholar +1 more source
Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells [PDF]
, 2017 Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation ...
Cippitelli, M +13 more
core +1 more source
Haematologica, 2015 Proteasome inhibitor resistance is a challenge for myeloma therapy. Bortezomib targets the β5 and β1 activity, but not the β2 activity of the proteasome.
Marianne Kraus +15 more
doaj +1 more source
Heat shock proteins in multiple myeloma [PDF]
Oncotarget, 2014 Heat shock proteins are molecular chaperones with a central role in protein folding and cellular protein homeostasis. They also play major roles in the development of cancer and in recent years have emerged as promising therapeutic targets. In this review, we discuss the known molecular mechanisms of various heat shock protein families and their ...
Jacqueline H. L. Fok +2 more
openaire +3 more sources
Efficacy and safety of bortezomib with dexamethasone regimen in elderly newly diagnosed multiple myeloma patients with co-morbidities [PDF]
, 2016 Bortezomib-based induction therapies have shown to increase complete response rates and are used as an upfront therapy for newly diagnosed multiple myeloma patients.
Lee, Saem
core +1 more source
Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]
, 2016 Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene +12 more
core +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Inhibition of fatty acid metabolism reduces human myeloma cells proliferation. [PDF]
PLoS ONE, 2012 Multiple myeloma is a haematological malignancy characterized by the clonal proliferation of plasma cells. It has been proposed that targeting cancer cell metabolism would provide a new selective anticancer therapeutic strategy.
José Manuel Tirado-Vélez +4 more
doaj +1 more source