Results 81 to 90 of about 5,838,181 (363)

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Lack of pokeweed mitogen-induced IgE formation in vitro by human peripheral blood mononuclear cells: detection of cross-reacting idiotypic determinants on polyclonal Ig by antibodies to a single IgE myeloma protein.

Journal of Immunology, 1983
The ability of human peripheral blood mononuclear cells to synthesize IgE in vitro in response to pokeweed mitogen (PWM) is controversial. To determine whether the conflicting results obtained by different laboratories could be due to inherent ...
H. Spiegelberg, J. M. Plummer, J. Ruedi, L. Thompson, M. Mellon, R. Zeiger   +5 more
semanticscholar   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Recommendations for use of tumor markers in monoclonal gammopathies [PDF]

Journal of Medical Biochemistry, 2007
Monoclonal gammopathies constitute a group of disorders characterized by the clonal proliferation of plasma cells. The M protein is a tumor marker specific for monoclonal gammopathies because it reflects the clonal production of immunoglobulin.
Dajak Marijana
doaj  

Structural studies of a human gamma 3 myeloma protein (Jir) bearing the allotypic marker Gm(st).

Journal of Immunology, 1983
The authors established the amino acid substitutions determining G3m(s) and G3m(t) specificities, which characterize Mongoloid populations, by sequence analysis of the Fc region of a myeloma protein (Jir).
H. Matsumoto, S. Ito, T. Miyazaki, T. Ohta   +3 more
semanticscholar   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Current Status and Challenges in Treatment of Relapsed/Refractory Multiple Myeloma

Zhongliu Fangzhi Yanjiu, 2019
Multiple myeloma remains an incurable hematological malignancy. In recent years, the application of many agents has improved the survival and life quality of patients.
WAN Yike, HOU Jian
doaj   +1 more source

Skin sensitizing antibodies: a comparative study of canine and human PK and PCA antibodies and a canine myeloma protein.

Journal of Immunology, 1967
Canine reaginic antibody from 13 atopic animals with hypersensitivity to ragweed pollens has been separated from other canine immunoglobulins, including the γM-globulins, a canine polymeric (10 S) myeloma protein and a canine γG-antibody eliciting a ...
J. H. Rockey, Robert M. Schwartzman
semanticscholar   +1 more source

Inferring Gene Regulatory Networks From Single‐Cell RNA Sequencing Data by Dual‐Role Graph Contrastive Learning

Advanced Science, EarlyView.
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan, Jiating Yu, Jieyi Pan, Fan Yuan, Jiadong Ji, Rusong Zhao, Zhi‐Ping Liu, Bingqiang Liu, Ling‐Yun Wu, Duanchen Sun   +9 more
wiley   +1 more source

Hypoxia-induced long non-coding RNA DARS-AS1 regulates RBM39 stability to promote myeloma malignancy

Haematologica, 2020
Multiple myeloma is a malignant plasma-cell disease, which is highly dependent on the hypoxic bone marrow microenvironment. However, the underlying mechanisms of hypoxia contributing to myeloma genesis are not fully understood.
Jia Tong, Xiaoguang Xu, Zilu Zhang, Chengning Ma, Rufang Xiang, Jia Liu, Wenbin Xu, Chao Wu, Junmin Li, Fenghuang Zhan, Yingli Wu, Hua Yan   +11 more
doaj   +1 more source