Results 101 to 110 of about 57,373 (239)

Structural analysis of Cu/Zn‐superoxide dismutase linked to neurodegenerative disease by antibody‐guided cryo‐EM

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Accumulation of misfolded proteins is a hallmark of many neurodegenerative diseases. To characterize such misfolded species in vivo, conformation‐specific antibodies are widely used; however, limited knowledge of antibody–epitope interactions often hampers mechanistic insight.
Yuki Shino, Norifumi Muraki, Yui Kobatake, Hiroaki Kamishina, Hirofumi Kosuge, Makoto Nakakido, Kouhei Tsumoto, Yoshiaki Furukawa   +7 more
wiley   +1 more source

A Chinese X‐Linked Adrenoleukodystrophy Patient With Atypical Clinical Symptoms Contained an Undefined ABCD1 Mutation—A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT X‐linked adrenoleukodystrophy (X‐ALD) is a genetic peroxisome disorder linked to ABCD1 mutation, characterized by rapid and complex clinical symptoms. We here report a case of X‐ALD manifesting solely as dysarthria, associated with an undefined mutation in the ABCD1 gene, underscoring the necessity of atypical clinical symptoms in X‐ALD ...
Fu‐Qing Zhang, Zhuoran Zhang, Dongliang Wang, Ying Yang, Xin Li   +4 more
wiley   +1 more source

Differences in the Demographics and Clinical Characteristics between the Ossification of the Posterior Longitudinal Ligament and Ossification of the Ligamentum Flavum in Patients Who Underwent Thoracic Spinal Surgery for Compressive Myelopathy

Neurologia Medico-Chirurgica
Ossification of the posterior longitudinal ligament (OPLL) and ossification of the ligamentum flavum (OLF) are related diseases associated with the ossification of spinal ligaments that can occasionally lead to thoracic myelopathy.
Shinsuke YOSHIDA, Sho NAKAMURA, Kazuo SAITA, Soichi OYA, Satoshi OGIHARA   +4 more
doaj   +1 more source

Frequency estimation of disease-causing mutations in the Belgian population of some dog breeds, part 1 : shepherds [PDF]

, 2016
In light of improving breeding advice, the frequency was estimated for all the disease-causing mutations that were known at the start of the study and that are potentially relevant for a group of dog breeds, which are relatively popular or in which the ...
Beckers, Evy, Peelman, Luc, Ronsyn, L, Van Poucke, Mario   +3 more
core   +1 more source

Vertebral Artery Occlusion With Ipsilateral Weakness Due to Ischemic Stroke at the Medulla–Cervical Spinal Cord Junction: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Posterior circulation strokes can present with diverse neurological deficits, some of which challenge conventional localization principles. We report a case of a 74‐year‐old male with a history of prior right medullary infarct who presented with recurrent symptoms and was found to have a new medullary acute ischemic stroke in the setting of ...
Peter Felton, Yugant Khand, Mohammad Gharavi, Ram Saha   +3 more
wiley   +1 more source

Editorial: Immune-mediated disorders of the spinal cord: Diagnosis, treatment strategies, and outcomes in the 21st century

Frontiers in Neurology, 2022
Giulia Fadda, Eoin P. Flanagan, Eoin P. Flanagan, Elia Sechi   +3 more
doaj   +1 more source

Global Burden Related to Nitrous Oxide Exposure in Medical and Recreational Settings: A Systematic Review and Individual Patient Data Meta-Analysis. [PDF]

, 2019
The risk of adverse effects of nitrous oxide (N2O) exposure is insufficiently recognized despite its widespread use. These effects are mainly reported through case reports. We conducted an individual patient data meta-analysis to assess the prevalence of
Filhine-Tresarrieu, Pierre, Franczak, Claire, Green, Ralph, Guéant, Jean-Louis, Hajjar, Olivia, Julien, Mélissa, Laugel, Elodie, Levy, Julien, Oussalah, Abderrahim, Stephan, Charlotte, Wandzel, Marion   +10 more
core   +3 more sources

Posterior Spinal Artery Infarction With Unilateral Lumbar Spinal Cord Lesion: A Challenge in Early Diagnosis

Journal of General and Family Medicine, Volume 27, Issue 3, May 2026.
ABSTRACT A 71‐year‐old woman presented with acute muscle weakness and paresthesia in her left lower limb with the preceding back pain and impaired deep sensation. Although initial brain and spinal MRI were normal, follow‐up spinal MRI confirmed the left‐sided posterior lesion at T10 to T12 vertebral level, leading to the diagnosis of posterior spinal ...
Munenori Iwamoto, Aoi Fukunaga, Toshiyuki Uehara   +2 more
wiley   +1 more source

Análise do líquido cefalorraqueano e neuropatogênese da infecção pelo HTLV-I Cerebrospinal fluid analysis and the pathogenesis of central nervous system infection by HTLV-I

Arquivos de Neuro-Psiquiatria, 1997
O mecanismo da mielopatia associada a infecção pelo HTLV-I (HAM), como ocorre o dano da medula espinhal e finalmente a destruição da mielina assim como do oligodendrócito não está definido.
Marzia Puccioni-Sohler
doaj   +1 more source

Clinical features of varicella-zoster virus infection [PDF]

, 2018
Varicella-zoster virus (VZV) is a pathogenic human herpes virus that causes varicella (chickenpox) as a primary infection, following which it becomes latent in peripheral ganglia.
Gershon, Anne A., Kennedy, Peter G.E.
core   +1 more source