Results 101 to 110 of about 3,367,821 (256)

Cerebrovascular Disorders Associated with Ph-Negative Myeloproliferative Diseases

Клиническая онкогематология, 2019
Background. Cerebrovascular disorders continue to be among the most common and socially significant worldwide. Among multiple reasons for circulatory disturbances special importance is attached to hemorheology and hemostasis disorders occurring also in ...
M. M. Tanashyan, Polina Igorevna Kuznetsova, A. L. Melikyan, A. A. Raskurazhev   +3 more
doaj   +1 more source

Sex differences in the JAK2V617F allele burden in chronic myeloproliferative disorders

Haematologica, 2010
Background The JAK2V617F allele burden is a variable measure, determined by the frequency of mitotic recombination events and the expansion of JAK2V617F clones.
B. Stein, Donna M. Williams, Nae-Yuh Wang, O. Rogers, M. Isaacs, N. Pemmaraju, J. Spivak, A. Moliterno   +7 more
semanticscholar   +1 more source

Combining Small‐Molecular Compounds With CAR T‐Cell Therapy: Novel Strategies for Enhanced Cancer Immunotherapy

Cancer Innovation, Volume 5, Issue 2, April 2026.
Chimeric antigen receptor (CAR) T‐cell therapy, although revolutionary for haematological malignancies, faces significant challenges, including T‐cell exhaustion, limited persistence, and treatment‐related toxicity. The integration of small‐molecule compounds offers a promising strategy to overcome these limitations.
Rangzi Yi, Zijian Zhang, Yang Yang, Haichuan Zhu   +3 more
wiley   +1 more source

The chronic myeloid leukemia stem cell: stemming the tide of persistence [PDF]

, 2017
Chronic myeloid leukaemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a haemopoietic stem cell (HSC), transforming it into a leukaemic stem cell (LSC) that self-renews, proliferates and differentiates to give rise to a ...
Holyoake, Tessa L., Vetrie, David
core   +1 more source

A Difficult‐to‐Manage Case of Primary Idiopathic Erythromelalgia—Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Erythromelalgia is a rare condition with symptoms of erythema, warmth, and painful extremities exacerbated by warmth and relieved by cooling. Pain management is often challenging. The sodium channel blocker, lacosamide, was most effective in this patient.
Sarah Wide, Rajish S. K. Shil, Bernhard Frank, Viraj Bharambe   +3 more
wiley   +1 more source

A mutação JAK2 V617F e as síndromes mieloproliferativas JAK2 V617F mutation and the myeloproliferative disorders

Revista Brasileira de Hematologia e Hemoterapia, 2008
Síndromes mieloproliferativas (SMPs) são doenças hematopoéticas de origem clonal que apresentam amplificação de uma ou mais linhagens mielóides. Policitemia vera (PV), trombocitemia essencial (TE), mielofibrose idiopática (MF) e leucemia mielóide crônica
Bárbara C. R. Monte-Mór, Fernando F. Costa   +1 more
doaj   +1 more source

KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]

, 2009
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny, K K Reichard, K Sotlar, M K Foucar, S A McClintock-Treep   +4 more
core   +1 more source

Stent Thrombosis: A Narrative Review From Pathophysiology to Therapy

Clinical Cardiology, Volume 49, Issue 4, April 2026.
Stent thrombosis remains a life‐threatening complication of PCI driven by complex interactions between stent design, procedural factors, thrombogenic milieu, and inflammation. This review integrates pathophysiological mechanisms with contemporary and emerging therapeutic strategies, highlighting optimized PCI, tailored antithrombotic therapy, and novel
Emanuele Cecchi, Andrea Grasso Granchietti, Ruggero Mazzotta, Manuel Garofalo, Giorgia Panichella, Giuseppe Iula, Francesca Maria Di Muro, Silvia Menale, Rossella Marcucci   +8 more
wiley   +1 more source

Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia

Case Reports in Hematology, 2016
The development of acute lymphoblastic leukemia in an existing myeloproliferative neoplasm is rare with historical cases unable to differentiate between concomitant malignancies or leukemic transformation.
Stephen E. Langabeer, Karl Haslam, David O’Brien, Johanna Kelly, Claire Andrews, Ciara Ryan, Richard Flavin, Patrick J. Hayden, Christopher L. Bacon   +8 more
doaj   +1 more source

Successful Haplo‐Hematopoietic Stem Cell Transplantation for Juvenile Myelomonocytic Leukemia in a Child With Underlying Thrombocytopenia‐Absent Radius Syndrome: A Unique Case

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Thrombocytopenia‐absent radius (TAR) syndrome is a rare congenital disorder characterized by bilateral radial aplasia with preserved thumbs and early‐onset thrombocytopenia. While hematologic and skeletal abnormalities define the condition, its association with hematologic malignancies is extremely rare, with only a few reported ...
Sondus Al Sharidah, Ahmed Elhussien, Walid I. A. Soliman, Nesma I. Ellithy   +3 more
wiley   +1 more source