Results 151 to 160 of about 24,077 (195)
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The Myeloproliferative Disorders
New England Journal of Medicine, 2006The discovery of an identical mutation (V617F) of the JAK2 gene in patients with polycythemia vera, essential thrombocythemia, and myelofibrosis — the principal Philadelphia chromosome–negative myeloproliferative disorders — has greatly advanced our understanding of these conditions.
Peter J, Campbell, Anthony R, Green
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Veterinary Clinics of North America: Small Animal Practice, 1985
Myeloproliferative disorders are uncommon in the dog and may be classified as chronic or acute. Excessive proliferation of mature cells leads to an overproduction of terminally differentiated blood cells (chronic MPD). Inability of cells to mature results in the accumulation of poorly differentiated blast cells in the peripheral blood and bone marrow ...
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Myeloproliferative disorders are uncommon in the dog and may be classified as chronic or acute. Excessive proliferation of mature cells leads to an overproduction of terminally differentiated blood cells (chronic MPD). Inability of cells to mature results in the accumulation of poorly differentiated blast cells in the peripheral blood and bone marrow ...
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Clonality in Myeloproliferative Disorders
The American Journal of the Medical Sciences, 1992The myeloproliferative disorders are a group of hematologic diseases that are believed to arise from somatic mutations in an early hematopoietic stem cell. This statement is based on the demonstration of monoclonal involvement of terminally differentiated myeloid and lymphoid elements.
K L, Blanchard +2 more
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Transient myeloproliferative disorder
Blood, 2012![Figure][1] An 11-day-old boy presented with high-grade fever since the second day of life. He was dysmorphic with Down syndrome (DS) facies, pallor, irritability, tachypnea, pan-systolic murmur, and hepatosplenomegaly.
Bushra, Moiz, Maria, Shafiq
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Myelodysplasia and myeloproliferative disorders
Current Opinion in Hematology, 1997Myelodysplasia and the myeloproliferative disorders are clonal hematopoietic stem cell disorders with heterogeneous clinical presentations and prognoses. This review highlights some of the recent progress that has been made in these disorders. Specifically, a number of studies have enhanced our understanding of the pathogenesis of these disorders, and ...
J E, Anderson, F R, Appelbaum
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Medicine, 2004
Myeloproliferative disorders are caused by abnormalities of hematopoietic stem cells leading to uncontrolled proliferation of one or more cell lines in the blood. Besides sharing common clinical and hematologic features they are characterized by clonal hematopoiesis and genetic instability, resulting in a disease-specific rate of transformation into ...
Tarja Juopperi, Heather Leigh DeHeer
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Myeloproliferative disorders are caused by abnormalities of hematopoietic stem cells leading to uncontrolled proliferation of one or more cell lines in the blood. Besides sharing common clinical and hematologic features they are characterized by clonal hematopoiesis and genetic instability, resulting in a disease-specific rate of transformation into ...
Tarja Juopperi, Heather Leigh DeHeer
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Chronic Myeloproliferative Disorders
Hematology, 2003AbstractThe Philadelphia chromosome-negative chronic myeloproliferative disorders (CMPD), polycythemia vera (PV), essential thrombocythemia (ET) and chronic idiopathic myelofibrosis (IMF), have overlapping clinical features but exhibit different natural histories and different therapeutic requirements.
Jerry L, Spivak +6 more
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Splenectomy for myeloproliferative disorders
World Journal of Surgery, 1985AbstractSplenectomy is highly successful in reversing hypersplenism associated with myeloproliferative disorders (MPD). Significant improvement in leukocyte, platelet, and erythrocyte counts usually occurs within 1 week of splenectomy. Relief of symptoms associated with progressive splenomegaly seen with these entities is also achieved by splenectomy ...
R E, Wilson +3 more
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Myeloproliferative Disorders in Pregnancy
Hematology/Oncology Clinics of North America, 2011This article reviews pregnancy outcome in women diagnosed with a myeloproliferative neoplasm (MPN), and discusses possible risk markers and the pathogenesis of poor pregnancy outcome. An outline of the key factors regarding the diagnosis and management of MPN in women of reproductive potential is followed by a description of the authors' management ...
Claire N, Harrison, Susan E, Robinson
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Phagocytosis in Myeloproliferative Disorders
American Journal of Clinical Pathology, 1980The phagocytic function was investigated by means of four tests (capillary tube random migration, phagocytosis of yeast particles, quantitative nitroblue tetrazolium dye reduction and whole-blood bactericidal activity for Staphylococcus aureus) in 57 patients who had myeloproliferative disorders: 24 had chronic granulocytic leukemia, 22 had ...
J, Corberand +4 more
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