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Diagnostic Approach to Myeloproliferative Neoplasms and Myelodysplastic/Myeloproliferative Neoplasms
Advances in Anatomic PathologyThe International Consensus Classification (ICC) updated in 2022 the World Health Organization (WHO) classification of hematopoietic tumors (2016 revision of the 4th edition WHO classification). Although the major categories of myeloid neoplasms remained unchanged from the prior WHO classification, many disease entities including those in the ...
Sonam Prakash, Attilio Orazi
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Inflammation and myeloproliferative neoplasms
Journal of Autoimmunity, 2017Myeloproliferative neoplasms (MPN) include three main entities: Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Myelofibrosis (MF). MPN represent a unique model of the relationship between the clonal development of a hematologic malignancy and chronic inflammation.
F. Lussana, A. Rambaldi
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2021
In the 2017 WHO classification, chronic myeloid neoplasms include myeloproliferative neoplasms (MPNs), myelodysplastic/myeloproliferative neoplasms (MDS/MPNs), myelodysplastic syndrome (MDS), mastocytosis and myeloid/lymphoid neoplasms with eosinophilia with rearrangements in FGFR1, PDGFRA, PDGFRB, or PCM1-JAK2 fusions.
Julie Li, Gang Zheng
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In the 2017 WHO classification, chronic myeloid neoplasms include myeloproliferative neoplasms (MPNs), myelodysplastic/myeloproliferative neoplasms (MDS/MPNs), myelodysplastic syndrome (MDS), mastocytosis and myeloid/lymphoid neoplasms with eosinophilia with rearrangements in FGFR1, PDGFRA, PDGFRB, or PCM1-JAK2 fusions.
Julie Li, Gang Zheng
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Genetics of the myeloproliferative neoplasms
Current Opinion in Hematology, 2011Since the discovery of the JAK2V617F mutation in 2005, an increasing number of somatic and germline genetic events responsible for myeloproliferative neoplasm (MPN) pathogenesis have been uncovered. The purpose of this review is to outline the most recent discoveries of the genetic alterations found in patients with MPNs.In addition to the JAK2V617F ...
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Cytogenetics of Myeloproliferative Neoplasms
2011The introduction of JAK2 mutation testing has changed dramatically the diagnostic algorithms for myeloproliferative neoplasms (MPNs) but there is still a place for conventional cytogenetic analysis in the initial work-up of MPN cases, particularly as this group of myeloid disorders has been expanded to include chronic eosinophilic leukaemia and myeloid
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Myeloproliferative and Myelodysplastic/Myeloproliferative Neoplasms
2011Myeloproliferative syndromes (MPS) are characterized by clonal proliferation patterns of hematological precursor cells with a tendency to develop acute leukemia. Cytopenias typically seen in myelodysplastic syndrome (MDS) are uncommon, as are dysplastic morphological features.
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