Results 161 to 170 of about 60,444 (298)
AIE‐Active Cationic Tripyrrole Targeting Mitochondrial SDHAF1 for Acute Myeloid Leukemia Therapy
Aggregate, Volume 7, Issue 3, March 2026.Cationic tripyrrole oligomers (Tri‐DPPy) selectively accumulate in mitochondria and suppress Complex II activity by binding to SDHAF1, thereby effectively eradicating AML cells both in vitro and in vivo. ABSTRACT Therapy‐resistant acute myeloid leukemia (AML) depends on mitochondrial oxidative phosphorylation (OXPHOS) to meet its energy demands, and ...
Wangxing Lin +6 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 3, March 2026.Etoposide mediated topoisomerase II inhibition in Cervical Cancer. ABSTRACT Background Etoposide is a semisynthetic derivative of podophyllotoxin and an FDA‐approved topoisomerase II inhibitor that induces DNA strand breaks leading to cancer cell death.
Nikitha Kotian +3 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 3, March 2026.ABSTRACT Background Existing evidence indicates that germline BRCA mutation (gBRCA‐m) may increase chemotherapy sensitivity and toxicity. However, its role in chemotherapy‐induced myelosuppression (CIM) remains unclear. We conducted this study to investigate the influence of gBRCA‐m on CIM incidence and severity in patients with epithelial ovarian ...
Hongtao Hu +13 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 3, March 2026.ABSTRACT Background Over half of esophageal cancer (EC) cases occur in China, where paclitaxel and platinum agents have become the preferred chemotherapeutic regimen for EC patients. However, there is a clinical need for a non‐platinum‐based therapeutic option.
Yun Wang +8 more
wiley +1 more source
Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.ABSTRACT The organotellurane RF07 (RF07) is an organic compound containing tellurium, a rare semi‐metal, and its leishmanicidal and antimalarial activity has already been reported in previous studies. This study evaluated the toxic effects of RF07 at 0.42, 21.37, and 42.75 mg/kg using comet assay, micronucleus test, and hematological/biochemical tests ...
Felipe Emannuel Alvino de Jesus +16 more
wiley +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.Abstract This study aims to explore the mechanism of action of the Bromodomain‐containing protein 4 (BRD4) inhibitor GNE‐987 in the treatment of pediatric T‐cell Acute Lymphoblastic Leukemia (T‐ALL), focusing on its effect in inhibiting T‐ALL cell proliferation by activating the HLA Complex P5 (HCP5) Super‐enhancer.
Xu Sang +6 more
wiley +1 more source
Cancer Reports, Volume 9, Issue 3, March 2026.ABSTRACT Background The malignant glioma, as the most common and aggressive primary brain and spinal cord neoplasm, has shown limited responsiveness to available treatments, including tumor dissection, radiation, and chemotherapy. Thus, interferon type I, as a supplemental therapy, is added to the main therapies to overcome neoplasm resistance and ...
Nima Goudarzi +4 more
wiley +1 more source
Splenic myelosuppressive syndrome. A case report [PDF]
Cancer, 1968 B C, Korbitz, C W, Reiquam, H D, Palmer
openaire +2 more sources
Cancer Reports, Volume 9, Issue 3, March 2026.ABSTRACT Background Myeloid sarcoma is a rare solid tumour of immature myeloid precursors occurring in an extramedullary site. It often presents significant diagnostic and therapeutic challenges to clinical haematologists. Case We describe a previously healthy patient who presented simultaneously with hyperleucocytic chronic myeloid leukaemia in ...
Kar Ying Yong +3 more
wiley +1 more source
Erythema Nodosum Associated with Myelodysplastic Syndrome: A Case Report [PDF]
, 2011 Adam, Christian +3 more
core +1 more source