Results 131 to 140 of about 18,051 (238)

Perinatal death in pig models of hypertrophic cardiomyopathy carrying sarcomere pathogenic variants

Journal of Molecular and Cellular Cardiology Plus
Hypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease caused by genetic variants in sarcomeric proteins, particularly in myosin binding protein C3 (MYBPC3) and myosin heavy chain 7 (MYH7).
Tatiana Flisikowska, Björn Petersen, Giulia Mearini, Daniela Huber, Mayuko Kurome, Melanie Stoff, Saskia Schlossarek, Andrea Lucas-Hahn, Eckhard Wolf, Judith Montag, Angelika Schnieke, Lucie Carrier   +11 more
doaj   +1 more source

Skeletal Muscle PGC-1β Signaling is Sufficient to Drive an Endurance Exercise Phenotype and to Counteract Components of Detraining in Mice [PDF]

, 2017
Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and -1β serve as master transcriptional regulators of muscle mitochondrial functional capacity and are capable of enhancing muscle endurance when overexpressed in mice.
Ayala, Julio, Coen, Paul M., Fitts, Robert H., Kelly, Daniel P., Lee, Samuel, Leone, Teresa C., Rogosa, Lisa, Rumsey, John, Vega, Rick B.   +8 more
core   +1 more source

Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy [PDF]

, 2015
Frameshift mutations in the TTN gene encoding titin are a major cause for inherited forms of dilated cardiomyopathy (DCM), a heart disease characterized by ventricular dilatation, systolic dysfunction, and progressive heart failure. To date, there are no
Alessandra, Moretti, Alexander, Goedel, Annemieke Aartsma, Rus, Brenda, Gerull, Daniel, Sinnecker, Elvira, Parrotta, John J., Atherton, Julie, Mcgaughran, Karl Ludwig, Laugwitz, Katja, Metzger, Ludwig, Thierfelder, Luna Simona, Pane, Martin, Schaller, Matthias, Mann, Meinrad Paul, Gawaz, Michael, Gramlich, Murgia, Marta, Qifeng, Zhou, Richard P., Harvey, Siegfried, Labeit, Sonja, Sch\uf6tterl, Thomas, Brade, Zhifen, Chen   +22 more
core   +1 more source

Incidence and Prevalence of Congenital Myopathies ‐ A Population‐Based Study From Western Sweden

Annals of Neurology, Volume 99, Issue 2, Page 382-392, February 2026.
Objective Congenital myopathies are a group of rare genetic muscle disorders. Previous studies have estimated point prevalences which only include surviving individuals. Our aim was to perform an epidemiological study with strict inclusion criteria, using modern diagnostic technology to present both incidences and prevalences, and to describe the ...
Eva Michael, Carola Hedberg‐Oldfors, Mar Tulinius, Sara Nordström, Anders Oldfors, Niklas Darin   +5 more
wiley   +1 more source

Fibre Type–Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resistance Training and Beta2‐Adrenergic Agonist

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Skeletal muscle is essential for metabolic health and physical function. While resistance training promotes muscle hypertrophy, alternative therapeutic strategies are needed for individuals unable to engage in physical activity. Because beta2‐adrenergic stimulation induces muscle growth without mechanical load, we assessed muscle ...
Søren Jessen, Andrea Di Credico, Roger Moreno‐Justicia, Lukas Moesgaard, Anders Lemminger, Ben Stocks, Angela Di Baldassarre, Jens Bangsbo, Atul S. Deshmukh, Morten Hostrup   +9 more
wiley   +1 more source

A case report of MYH7 mutation-induced restrictive cardiomyopathy

European Heart Journal - Case Reports
Abstract Background Restrictive cardiomyopathy (RCM) is characterized by impaired diastolic function and ventricular filling, often due to genetic and environmental factors. The MYH7 gene, encoding myosin heavy chain in muscle fibres critical for muscle contraction, has been implicated in RCM.
Shaozhen Zhang, Wang Zhao
openaire   +2 more sources

Context‐Dependent Roles of ANGPTL2‐Mediated Inflammaging in Tissue Homeostasis, Pathological Tissue Remodeling, and Longevity

Aging Cell, Volume 25, Issue 2, February 2026.
Yumoto et al. show that ANGPTL2 regulates inflammation, fibrosis, and tissue remodeling in high‐fat diet‐induced premature aging. ANGPTL2 deficiency shortens lifespan but reduces inflammation, revealing its context‐dependent and organ‐specific roles in maintaining homeostasis.
Shinsei Yumoto, Haruki Horiguchi, Keishi Miyata, Tsuyoshi Kadomatsu, Zhe Tian, Michio Sato, Kimi Araki, Masaaki Iwatsuki, Yuichi Oike   +8 more
wiley   +1 more source

Prevalence and Phenotypic Expression of Mutations in the MYH7, MYBPC3 and TNNT2 Genes in Families with Hypertrophic Cardiomyopathy in the South of Brazil: A Cross-Sectional Study

Arquivos Brasileiros de Cardiologia
Background: Mutations in sarcomeric genes are found in 60-70% of individuals with familial forms of hypertrophic cardiomyopathy (HCM). However, this estimate refers to northern hemisphere populations. The molecular-genetic profile of HCM has been subject
Beatriz Piva e Mattos, Fernando Luís Scolari, Marco Antonio Rodrigues Torres, Laura Simon, Valéria Centeno de Freitas, Roberto Giugliani, Úrsula Matte   +6 more
doaj   +1 more source

RFeusenarcchtional polymorphisms in genes of the Angiotensin and Serotonin systems and risk of hypertrophic cardiomyopathy: AT1R as a potential modifier [PDF]

, 2011
Background: Angiotensin and serotonin have been identified as inducers of cardiac hypertrophy. DNA polymorphisms at the genes encoding components of the angiotensin and serotonin systems have been associated with the risk of developing cardiovascular ...
Berrazueta, J.R. (José), Corao, A.I. (Ana), Coto, Eliecer, Díaz, Marta, García, Cristina, García, Mónica, Martín, María, Morales, Blanca, Morís, César, Ortega, Francisco, Palacín, María, Reguero, J.R. (Julián), Tavira, Beatriz, Álvarez, Victoria   +13 more
core  

The Effect of 14 Weeks of Endurance Training on MYH7 and MYH7β Gene Expression and Left Ventricular Structural Changes in Male Wistar Rats

Armaghane Danesh Bimonthly Journal, 2019
Background & aim:  MYH7 and MYH7β genes play important roles in cardiac function. Endurance activity, on the other hand, challenges the structure and function of the heart. The aim of the present study was to determine and evaluate the effect of 14 weeks
R Rezaei, M Fathi
doaj