Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish [PDF]
JCI Insight, 2021 Myosin heavy chain 7 (MYH7) is a major causative gene for hypertrophic cardiomyopathy, but the affected signaling pathways and therapeutics remain elusive.
Haisong Bu +8 more
doaj +4 more sources
Natural History of MYH7-related Dilated Cardiomyopathy. [PDF]
Journal of the American College of Cardiology, 2022 Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described.We sought to determine the phenotype and prognosis of MYH7-related DCM.
Fernando de Frutos +39 more
semanticscholar +21 more sources
Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides [PDF]
Molecular Therapy: Nucleic Acids, 2020 Hundreds of dominant-negative myosin mutations have been identified that lead to hypertrophic cardiomyopathy, and the biomechanical link between mutation and disease is heterogeneous across this patient population. To increase the therapeutic feasibility
Brian R. Anderson +20 more
doaj +3 more sources
A Family with Myh7 Mutation and Different Forms of Cardiomyopathies
Biomedicines, 2023 Background: Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are common heart muscle disorders that are caused by pathogenic variants in sarcomere protein genes.
Bianca Iulia Catrina +7 more
semanticscholar +4 more sources
YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy [PDF]
Cell & Bioscience, 2021 Pathological cardiac hypertrophy is a major contributor of heart failure (HF), which seriously threatens human’s health world widely. Deregulation of m6A RNA methylation, and m6A methyltransferases and de-methyltransferases have been demonstrated to act ...
Hongfei Xu +7 more
semanticscholar +4 more sources
Sex-Specific Expression Patterns of MYH6 and MYH7 Gene Transcripts in Large Cohorts of Non-Failing and Failing Human Left Ventricular Tissues [PDF]
Journal of Cardiovascular Development and DiseaseThe transcriptional regulation of MYH6 and MYH7 genes has been extensively investigated in healthy versus failing hearts; however, their expression dynamics in healthy human hearts across age and sex, particularly in the context of cardiovascular risk ...
Zdenko Červenák +6 more
doaj +2 more sources
Lower left ventricular ejection time in MYBPC3 variant carriers with overt or subclinical hypertrophic cardiomyopathy [PDF]
ESC Heart FailureAims Hypertrophic cardiomyopathy (HCM) is an inherited cardiomyopathy often caused by pathogenic variants in MYBPC3 and MYH7, encoding myosin‐binding protein C3 and myosin heavy chain 7, respectively.
Isabell Yan +10 more
doaj +2 more sources
Clinical Features and Outcomes of Pediatric MYH7‐Related Dilated Cardiomyopathy
Journal of the American Heart AssociationBackground Although genetic variants in MYH7 are the most frequent cause of pediatric genetic dilated cardiomyopathy (DCM), there are no studies available describing this entity.
Fernando de Frutos +21 more
semanticscholar +5 more sources
Electrophysiological Characterization of a MYH7 Variant with Tremor Phenotype
Movement Disorders Clinical Practice, 2023 The concept of a myopathy with associated tremor (“myogenic tremor”) in humans has been previously described for specific MYBPC1 (Myosin‐Binding Protein C) variants.
Felipe Vial +10 more
semanticscholar +3 more sources
Genotype-Phenotype Correlation in Hypertrophic Cardiomyopathy: New Variant p.Arg652Lys in MYH7 [PDF]
Genes, 2022 Hypertrophic cardiomyopathy (HCM) is a genetic disease characterised by increased left ventricle (LV) wall thickness caused by mutations in sarcomeric genes.
G. Antoniutti +9 more
semanticscholar +5 more sources