Results 21 to 30 of about 18,051 (238)

Sacubitril/Valsartan Ameliorates Crizotinib-Induced Cardiotoxicity in Mice

Reviews in Cardiovascular Medicine, 2023
Background: Lung cancer is one of the major cause of death globally. Crizotinib is a first-line drug used in treating non-small-cell lung cancer (NSCLC). However, the pathophysiological mechanisms underlying its cardiotoxicity are unknown.
Lijun Cheng, Junying Duan, Gary Tse, Tong Liu, Guangping Li   +4 more
doaj   +1 more source

Experience in genetic testing of hypertrophic cardiomyopathy using nanopore DNA sequencing

Российский кардиологический журнал, 2021
Aim. To investigate the application of the Oxford Nanopore Technologies’ third generation sequencing for the genetic testing of hypertrophic cardiomyopathy.Material and methods.
R. R. Salakhov, M. V. Golubenko, E. N. Pavlukova, A. N. Kucher, N. P. Babushkina, N. R. Valiahmetov, A. V. Markov, E. O. Belyaeva, A. F. Kanev, M. S. Nazarenko   +9 more
doaj   +1 more source

Generation of a homozygous MYH7 gene knockout human embryonic stem cell line (WAe009-A-69) using an episomal vector-based CRISPR/Cas9 system

Stem Cell Research, 2021
Myosin heavy chain 7 (MYH7) encodes the human heart myosin heavy chain subunit, which plays an important role in myocardial contraction. MYH7 is the main pathogenic gene that causes Hypertrophic cardiomyopathy (HCM) and Dilated cardiomyopathy (DCM).
Tianwei Guo, Youxu Jiang, Yuanxiu Song, Shuhong Ma, Yun Chang, Siyao Zhang, Hongyue Wang, Tao Dong, Hongfeng Jiang, Wenjing Lu   +9 more
doaj   +1 more source

Recessive MYH7-related myopathy in two families [PDF]

Neuromuscular Disorders, 2019
Myopathies due to recessive MYH7 mutations are exceedingly rare, reported in only two families to date. We describe three patients from two families (from Australia and the UK) with a myopathy caused by recessive mutations in MYH7. The Australian family was homozygous for a c.5134C > T, p.Arg1712Trp mutation, whilst the UK patient was compound ...
Beecroft, Sarah J., van de Locht, Martijn, de Winter, Josine M., Ottenheijm, Coen A., Sewry, Caroline A., Mohammed, Shehla, Ryan, Monique M., Woodcock, Ian R., Sanders, Lauren, Gooding, Rebecca, Davis, Mark R., Oates, Emily C., Laing, Nigel G., Ravenscroft, Gianina, McLean, Catriona A., Jungbluth, Heinz   +15 more
openaire   +4 more sources

Genetic Study of Hypertrophic Cardiomyopathy in Iranian children: The Role of a De novo Variant [PDF]

پژوهان, 2023
Background and Objectives: Hypertrophic cardiomyopathy is a common cardiac disease diagnosed in young adults and rarely detectable in childhood. Hypertrophic cardiomyopathy exhibits considerable diversity in its clinical and genetic characteristics.
Arastoo Kaki, Mohammad Dalili, Nejat Mahdieh, Mehrdad Noruzinia   +3 more
doaj  

The protective effect of Apelin-13 against cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): To determine the protective effect of Apelin-13 on cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway.Materials and Methods: The phenylephrine-induced cardiomyocyte hypertrophy model was established in H9C2 cells in ...
Yu Peng, Ruan Jingming, Chen Shaowen, Huang Feng, Zhu Pengli   +4 more
doaj   +1 more source

Unique Transcriptional Profile of Sustained Ligand-Activated Preconditioning in Pre- and Post-Ischemic Myocardium [PDF]

, 2013
BACKGROUND: Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3–5 days of opioid receptor (OR) agonism induces persistent protection against ischemia-reperfusion (I-R) injury in young and aged hearts, and is mechanistically distinct
Ashton, Kevin J., Headrick, John P., Kiessling, Can J., Peart, Jason N., See Hoe, Louise E., Tupicoff, Amanda, Williams-Pritchard, Grant   +6 more
core   +6 more sources

Rapid diagnostic testing of a neonate in a family with hypertrophic cardiomyopathy

Clinical and Experimental Obstetrics & Gynecology, 2020
Familial hypertrophic cardiomyopathy (HCM) is a common but severe genetic disease. A pregnant woman with familial HCM was referred to our hospital as both the couple and their families were concerned that the baby would later develop HCM.
H. Ueda, T. Miyamoto, Y. Tsurusaki, G. Minase, N. Matsumoto, K. Sengoku   +5 more
doaj   +1 more source

Impaired muscle morphology in a Drosophila model of myosin storage myopathy was suppressed by overexpression of an E3 ubiquitin ligase

Disease Models & Mechanisms, 2020
Myosin is vital for body movement and heart contractility. Mutations in MYH7, encoding slow/β-cardiac myosin heavy chain, are an important cause of hypertrophic and dilated cardiomyopathy, as well as skeletal muscle disease. A dominant missense mutation (
Martin Dahl-Halvarsson, Montse Olive, Malgorzata Pokrzywa, Michaela Norum, Katarina Ejeskär, Homa Tajsharghi   +5 more
doaj   +1 more source

Low-frequency maternal novel MYH7 mosaicism mutation in recurrent fetal-onset severe left ventricular noncompaction: a case report

Frontiers in Pediatrics, 2023
BackgroundLeft ventricular noncompaction (LVNC) is a rare inherited cardiomyopathy with a broad phenotypic spectrum. The genotype-phenotype correlations in fetal-onset LVNC have not yet been fully elucidated.
Hiroshi Kawamura, Masamichi Ikawa, Keiichi Hirono, Junya Kimura, Takashi Okuno, Masao Kawatani, Masao Kawatani, Kunihiro Inai, Yukiko Hata, Naoki Nishida, Yoshio Yoshida   +10 more
doaj   +1 more source