Results 191 to 200 of about 5,458,082 (292)

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Artificial Intelligence-Based Arterial Input Function for the Quantitative Assessment of Myocardial Blood Flow and Perfusion Reserve in Cardiac Magnetic Resonance: A Validation Study. [PDF]

Diagnostics (Basel)
van der Meulen LR, van Dinther M, Chiribiri A, Smink J, Crucial Investigators, Backes WH, Bennett J, Wildberger JE, Scannell CM, Holtackers RJ.   +9 more
europepmc   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Myocardial blood flow quantification in patients with an implanted cardiodefibrillator during stress and at rest using a wideband perfusion pulse sequence: an initial feasibility study. [PDF]

J Cardiovasc Magn Reson
Fan L, Jimenez MD, Bishara D, Urban J, Hong K, Culver AE, Collins JD, Hsu LY, Wang S, Patel AR, Aboyewa OB, Topel C, Lee DC, Kim D.   +13 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

⁸²Rb positron emission tomography myocardial blood flow quantification: Influence of arterial input curve quality on diagnostic accuracy. [PDF]

J Nucl Cardiol
Fujito H, Lemley M, Builoff V, Zhang W, Kuronuma K, Ramirez G, Killekar A, Liang JX, Kavanagh P, Hyun MC, Hayes SW, Thomson LEJ, Friedman JD, Van Kriekinge SD, Di Carli MF, Dey D, Berman DS, Slomka PJ.   +17 more
europepmc   +1 more source

Biomarkers of lung congestion and injury in acute heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi, Gabriele Novello, Francesca Bursi, Anna Caretti, Noemi Furlotti, Ross Arena, Paola Argiento, Julio Núñez, Antoni Bayes‐Genis, Marco Metra   +9 more
wiley   +1 more source

The impact of fast vs. slow rubidium-82 infusion profile on precision and accuracy of PET myocardial blood flow perfusion metrics using a 1-tissue compartment model. [PDF]

Eur Heart J Imaging Methods Pract
Koos A, Milani RV, Velasco-Gonzalez C, Morin DP, Bober RM.   +4 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

A ketogenic-promoting beverage acutely elevates cardiac function and myocardial blood flow compared to placebo in adults: A cardiac MRI investigation. [PDF]

Physiol Rep
Crabtree CD, Pan Y, Chandrasekaran P, Wang Y, Scandling D, Bedell T, Stoner J, Decker D, Kackley M, Robinson B, Buga A, Han Y, Volek J, Simonetti OP.   +13 more
europepmc   +1 more source