Results 131 to 140 of about 229,436 (314)

Potential Protective Effects of Boldine in Rat with an Experimental Myocardial Ischemia-Reperfusion Model [PDF]

Objectives: Myocardial ischemia-reperfusion injury (MIRI) remains a major challenge in cardiovascular medicine due to its complex pathophysiology involving oxidative stress, inflammation, and cellular dysfunction.
SEZEN, ŞABAN CEM, Yığman, Zeynep, Ali Doğan Dursun, KÜÇÜK, AYŞEGÜL, DEMİRTAŞ, HÜSEYİN, Zeynep Yığman, Ayşegül Küçük, YILDIRIM, ALPEREN KUTAY, YIĞMAN, ZEYNEP, ÖZER, ABDULLAH, Mustafa Arslan, Şaban Cem Sezen, DURSUN, ALİ DOĞAN, Hüseyin Demirtaş, Abdullah Özer, Alperen Kutay Yıldırım, Dursun, Alı Dogan, Yıldırım, Alperen Kutay, ARSLAN, MUSTAFA   +18 more
core   +1 more source

Levosimendan in Regional Myocardial Ischemia

Cardiovascular Drugs and Therapy, 2002
Levosimendan is a new positive inotropic agent with anxillary vasodilating effects. It increases heart rate, stroke volume, and cardiac output and decreases systemic, pulmonary and coronary artery vascular resistance as well as filling pressures [1]. Its mode of action is believed to involve a unique calcium sensitizing effect: it binds to Troponin C ...
openaire   +3 more sources

TWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays

Arthritis &Rheumatology, EarlyView.
Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...
Yale Liu, Zhu Yan, Xueting Peng, Meixuan Li, Juan Wang, Yan Zhang, Xiaoqian Hu, Mingzhu Zhou, Kaixuan Ren, Dan Zhang, Xingyi Guo, Yumin Xia, Huanhuan Huo   +12 more
wiley   +1 more source

Inferring Rheumatoid Arthritis Disease Activity Status From the Electronic Health Records Across Health Systems

Arthritis &Rheumatology, EarlyView.
Objective Disease activity plays a central role in rheumatoid arthritis (RA) clinical studies. The inconsistent availability of data on disease activity in real‐world electronic health records (EHRs) data has limited the ability to generate real‐world evidence (RWE).
David Cheng, Xuan Wang, Gregory C. McDermott, Jennifer S. Hanberg, Zoe Love, Katherine Zhong, Mary Jeffway, Jue Hou, Vidul Panickan, Rahul Sangar, Ying Qi, Connor Melley, Lauren Costa, Dakota Feil, Rachael Matty, Dana Weisenfeld, Abisayo Animashaun, Aimee Schreiner, Sara Morini, Lauren Rusnak, Andrew Cagan, Misti Paudel, J. Michael Gaziano, Brian Sauer, Michael Weinblatt, Joshua Baker, Bryant England, Yuk‐Lam Ho, Kelly Cho, Paul Monach, Grant W. Cannon, Nancy Shadick, Ted R. Mikuls, Tianxi Cai, Katherine P. Liao   +34 more
wiley   +1 more source

Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling

, 2003
Background— Transplantation of endothelial progenitor cells (EPCs) improves vascularization and left ventricular function after experimental myocardial ischemia.
Dimmeler, S, Henze, E, Aicher, A, Brenner, W, Eckey, T, Zuhayra, M, Badorff, C, Assmus, B, Massoudi, S, Zeiher, AM   +9 more
core  

Corrigendum: C1q/TNF-Related Protein 9 Attenuates Atherosclerosis by Inhibiting Hyperglycemia-Induced Endothelial Cell Senescence Through the AMPKα/KLF4 Signaling Pathway

Frontiers in Pharmacology, 2021
Gang Wang, Gang Wang, Baihe Han, Baihe Han, Ruoxi Zhang, Qi Liu, Qi Liu, Xuedong Wang, Xuedong Wang, Xingtao Huang, Xingtao Huang, Dandan Liu, Dandan Liu, Weishen Qiao, Weishen Qiao, Mengyue Yang, Mengyue Yang, Xing Luo, Xing Luo, Jingbo Hou, Jingbo Hou, Bo Yu, Bo Yu   +22 more
doaj   +1 more source

Human Fibroblast‐Myeloid cell tissue atlas across lung, synovium, skin and heart

Arthritis &Rheumatology, Accepted Article.
Background The availability of single‐cell RNA sequencing (scRNAseq data) in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source

Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia

, 2006
Background— Stem and progenitor cell therapy is a novel approach to improve neovascularization and function of ischemic tissue. Enhanced tissue expression of chemoattractant factors such as stromal cell–derived factor 1 and vascular endothelial growth ...
Dimmeler, S, Aicher, A, Heeschen, C, Sasaki, K, Urbich, C, Zeiher, AM   +5 more
core  

Cold-driven biphasic vascular healing in elderly patients: 4D optical coherence tomography stratification of major adverse cardiovascular event risk based on age-environment interactions

Frontiers in Cardiovascular Medicine
BackgroundBiological aging and prolonged cold exposure each impair vascular healing after implantation of a drug-eluting stent. However, their combined effect—particularly in older adults living in cold climates—remains poorly understood.ObjectiveTo ...
Linxing Feng, Linxing Feng, Huaxing Liu, Huaxing Liu, Zhiyong Li, Zhiyong Li, Lei Xing, Lei Xing   +7 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source