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Panax Notoginseng Saponins Attenuate Myocardial Ischemia-Reperfusion Injury Through the HIF-1&agr;/BNIP3 Pathway of Autophagy

Journal of Cardiovascular Pharmacology, 2019
Background and Objective: Panax Notoginseng Saponins (PNS) is a formula of Chinese medicine commonly used for treating ischemia myocardial in China. However, its mechanism of action is yet unclear.
Xinwen Liu   +4 more
semanticscholar   +1 more source

Mechanisms of myocardial ischemia

Cardiovascular Drugs and Therapy, 1990
The very first presentation of ischemic heart disease--acute infarction, sudden death, or unstable angina--most often occurs abruptly. The first approximation that it occurs as a random event only when a certain "threshold severity" of coronary atherosclerosis has gradually developed, although widely accepted, should perhaps be reconsidered and ...
openaire   +2 more sources

The novel relationship between Sirt3 and autophagy in myocardial ischemia–reperfusion

Journal of Cellular Physiology, 2018
Class III histone deacetylases (HDACs) belong to the proteasome family, comprising seven family members identified in mammalian cells, identified Sirt1–Sirt7. As an important member of HDACs, Sirt3 is hotly debated for its multiple functions.
Yitian Zheng   +4 more
semanticscholar   +1 more source

Chemokines in Myocardial Ischemia

Trends in Cardiovascular Medicine, 2005
Chemokine expression is markedly upregulated in healing myocardial infarcts and may play an important role in regulating leukocyte infiltration and activity and in modulating infarct angiogenesis as well as fibrous tissue deposition. The CC chemokine monocyte chemoattractant protein-1/CCL2 has important effects in infarct healing.
Mark L. Entman   +1 more
openaire   +2 more sources

'Myocardial Ischemia-Reperfusion Injury and the Influence of Inflammation.

Trends in cardiovascular medicine, 2022
M. Algoet   +6 more
semanticscholar   +1 more source

pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury.

Journal of the American Chemical Society, 2016
Hydrogen sulfide (H2S) is a critical signaling molecule that regulates many physiological and/or pathological processes. Modulation of H2S levels could have potential therapeutic value.
Jianming Kang   +8 more
semanticscholar   +1 more source

Image-Guided Hydrogen Gas Delivery for Protection from Myocardial Ischemia-Reperfusion Injury via Microbubbles.

ACS Applied Materials and Interfaces, 2017
Cardiomyocyte death induced by ischemia-reperfusion is a major cause of morbidity and mortality worldwide. Hydrogen (H2), as an antioxidant, has been shown to have great potential in preventive and therapeutic applications against lethal injury that ...
Yingjuan He   +6 more
semanticscholar   +1 more source

Thrombocytopenia and Myocardial Ischemia

JAMA: The Journal of the American Medical Association, 1974
Two patients had myocardial ischemia in a setting of chronic thrombocytopenia. Awareness of such occurrences should stimulate the reporting of other cases, so that the role of quantitative changes in platelets on the course of ischemic heart disease may receive greater attention. ( JAMA 228:1568-1569, 1974)
openaire   +3 more sources

On the genesis of myocardial ischemia

Zeitschrift f�r Kardiologie, 2004
About three quarters of myocardial ischemic events are triggered by the autonomic nervous system. The pathognomonic constellation is a combination of an almost complete withdrawal of tonic vagal activity with increased sympathetic activity. The reduction of tonic vagal activity, which is characteristic for ischemic heart disease, and the acute ...
openaire   +2 more sources

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