Results 121 to 130 of about 416,720 (250)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Elevated cardiovascular risk associated with hormone replacement therapy: A comprehensive analysis of reproductive factors and atherosclerotic cardiovascular disease outcomes in the UK Biobank cohort

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Among 170,250 UK Biobank women (2006–2024), ever HRT use was associated with higher incident ASCVD risk (adjusted HR 1.13, 95% CI 1.08–1.18), largely driven by ischemic stroke. Associations were stronger in women ≤45 years and during perimenopause. Mediation via sex hormones, inflammatory markers, or lipids was minimal (<2%).
Mengchun Wang, Can Zhang, Chunlai Yang, Baosen Meng, Xiaohui Li, Qian Huang, Baibing Mi   +6 more
wiley   +1 more source

Post-Myocardial Revascularization: As a Nidus for an Electrical Storm! [PDF]

Cureus, 2023
Belharty N, El Ghali T, Siagh S, Choho Z, Benmessaoud FA, Fellat I, Oukerraj L, Cherti M.   +7 more
europepmc   +1 more source

The impact of coronary artery bypass grafting on the short‐ and long‐term development and progression of diabetic retinopathy: A Danish national matched cohort study

Acta Ophthalmologica, EarlyView.
Abstract Purpose Diabetic retinopathy (DR) is a frequent long‐term complication of diabetes. While hemodynamic changes are known risk factors for DR, the effect of coronary artery bypass grafting (CABG) on the development of DR is poorly investigated.
Lukas Greve Maschoreck, Lonny Stokholm, Frederik Nørregaard Pedersen, Nis Andersen, Jens Andresen, Toke Bek, Sebastian Dinesen, Javad Hajari, Steffen Heegaard, Kurt Højlund, Caroline Schmidt Laugesen, Ryo Kawasaki, Sören Möller, Katja Christina Schielke, Yousif Subhi, Anne Suhr Thykjær Petersen, Jakob Grauslund   +16 more
wiley   +1 more source

The burden of diabetic foot ulcers in a multi‐ethnic Asian cohort

Diabetic Medicine, EarlyView.
Abstract Aims Diabetic foot ulcers (DFUs) are a major source of morbidity among individuals with diabetes mellitus (DM), imposing a substantial burden on healthcare systems. Our institution established a multidisciplinary service aiming to facilitate early specialist intervention for DFU management.
Zongwen Wee, Yong Mong Bee, Sueziani Binte Zainudin   +2 more
wiley   +1 more source

Revascularization in Severe Left Ventricular Dysfunction: Does Myocardial Viability Even Matter?

, 2015
Left ventricular dysfunction is a powerful prognostic predictor in patients with coronary artery disease and increasing number of patients with CAD and ischemic left ventricular (LV) dysfunction is a major clinical problem.
Hani Kozman, Nishant Sethi, Navneet Kaur, Pahul Singh   +3 more
core   +1 more source

Wearable Electronic Monitoring of Vital Signs in Hospitalised Adults: A Nursing Focused Scoping Review of Clinical, Economic and Implementation Outcomes

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To synthesise evidence on wearable devices for continuous vital signs monitoring in adult hospital inpatients, focusing on clinical effectiveness, nursing perspectives, workflow impact, patient experience and resource implications. Design Scoping review.
Sian Myfanwy Shaw, Sophie Bethan Shaw, Gillian Janes   +2 more
wiley   +1 more source

Association Between Optimal Revascularization for Chronic Total Occlusion and Long‐Term Outcomes in Patients With Heart Failure With or Without Type 2 Diabetes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The relationship between optimal revascularization for chronic total occlusion (CTO) lesions and long‐term clinical outcomes in patients with heart failure with or without type 2 diabetes (T2D) remains unclear.
Yanjun Song, Zhangyu Lin, Jining He, Rui Fu, Kefei Dou   +4 more
doaj   +1 more source

Cardiovascular preventive role of thiazolidinedione in patients with type 2 diabetes mellitus undergoing percutaneous coronary intervention

Journal of Diabetes Investigation, EarlyView.
Among patients with type 2 diabetes undergoing percutaneous coronary intervention, thiazolidinedione use was independently associated with a significantly reduced risk of a composite of myocardial infarction, stroke, and all‐cause death, notably without an increased risk of admission for heart failure. ABSTRACT Background Thiazolidinediones (TZD) are a
Jinkwon Kim, Jimin Jeon, Joonsang Yoo, Minyoul Baik, Seok‐Jae Heo, Ji Woong Roh   +5 more
wiley   +1 more source

Myocardial revascularization results: electrical, structural, and geometric left ventricular remodelling in diastolic heart failure

Кардиоваскулярная терапия и профилактика, 1970
Aim. To assess the dynamics of structural and geometric left ventricular (LV) remodelling and myocardial electrical instability in patients with post-infarction cardiosclerosis (PICS), at baseline and one year after coronary artery bypass graft (CABG ...
I. P. Tatarchenko, N. V. Pozdnyakova, I. A. Petrushin, O. I. Morozova, A. G. Mordovina   +4 more
doaj