Results 41 to 50 of about 443,078 (244)

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Effect of myocardial revascularization upon long-term prognosis of patients with acute coronary syndrome and concomitant dıseases [PDF]

, 2019
The aim – to assess the prognostic effect of myocardial revascularization in patients with acute coronary syndrome (ACS) with comorbidity or multimorbidity. Materials and methods.
R.R. Komorovsky
core   +2 more sources

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR‐4913

Advanced Science, EarlyView.
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao, Yanchun Li, Nan Li, Juan Zhang, Xiaolong Ma, Fei Yang, Ruihan Long, Yining Tian, Yichen Wang, Shengchao Ma, Huiping Zhang, Yideng Jiang   +11 more
wiley   +1 more source

Surgical revascularization in patients with acute myocardial infarction [PDF]

, 1993
This retrospective study was done to access the results of emergency revascularization in patients with acute myocardial ...
Eckel, Lothar, Satter, Peter, Maut, Frank, Mitrev, Zan, Beyersdorf, Friedhelm, Wendt, Th, Sarai, Koppany   +6 more
core   +1 more source

The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events

JACC: Advances
Background: Observational data have suggested that patients with moderate to severe ischemia benefit from revascularization. However, this was not confirmed in a large, randomized trial. Objectives: Using a contemporary, multicenter registry, the authors
Robert JH. Miller, MD, Bryan Bednarski, MSc, Yujie Cui, MSc, Vinicius Calsavara, PhD, Krishna Patel, MD, Alan Rozanski, MD, Joanna X. Liang, MPH, Valerie Builoff, BSc, Wanda Acampa, MD, Timothy M. Bateman, MD, Marcelo Di Carli, MD, Sharmila Dorbala, MD, MPH, Andrew J. Einstein, MD, PhD, Matthews B. Fish, MD, M. Timothy Hauser, MD, Philipp A. Kaufmann, MD, Edward J. Miller, MD, PhD, Terrence D. Ruddy, MD, Tali Sharir, MD, Albert J. Sinusas, MD, Damini Dey, PhD, Daniel S. Berman, MD, Piotr J. Slomka, PhD   +22 more
doaj   +1 more source

Implantable Systems for Cardiovascular Treatment and Monitoring: Comparative Insights From Intracardiovascular and Extracardiovascular Technologies

Advanced Intelligent Systems, EarlyView.
A unifying device–cardiovascular interface framework is presented to classify implantable cardiovascular technologies as intracardiovascular blood‐contacting systems or extracardiovascular tissue‐only and blood‐handling architectures. Cross‐class comparison across shared semiquantitative criteria, including blood‐contact burden, biomimicry ...
Bergo Nicolò, Semproni Federica, Maselli Martina, Colli Andrea, Cianchetti Matteo, Ciuti Gastone, Stefanini Cesare, Menciassi Arianna   +7 more
wiley   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Colchicine to Reduce Atrial Fibrillation in the Postoperative Period of Myocardial Revascularization

Arquivos Brasileiros de Cardiologia, 2016
Background: The high prevalence of atrial fibrillation (AF) in the postoperative period of myocardial revascularization surgery increases morbidity and mortality.
Camila Stuchi Zarpelon, Miguel Chomiski Netto, José Carlos Moura Jorge, Cátia Carolina Fabris, Dieli Desengrini, Mariana da Silva Jardim, Diego Guedes da Silva   +6 more
doaj   +1 more source

Complete revascularization in elderly patients with myocardial infarction-a safe, effective, and necessary strategy? [PDF]

, 2023
The FIRE trial compared culprit-only revascularization to physiology-guided complete revascularization strategy in elderly patients presenting with myocardial infarction. The study has shown that it is a safe approach and may confer additional prognostic
Gue, Ying X., Lip, Gregory YH, Lip, Gregory Y. H., Gue, Ying X   +3 more
core   +1 more source