Results 141 to 150 of about 430,076 (285)
Generative Algorithms for Myocardial-Scar-Tissue structures
embargoed_20260327This work examines machine-learning algorithm for generating the organic shape of a myocardial scar within a human heart geometry. This approach creates a set of plausible scars, which can be filtered to represent relevant features and ...
BAYER PUERTA, VICTOR HANS
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Value of 12-lead electrocardiogram to predict myocardial scar on FDG PET in heart failure patients
, 2019 PURPOSE A surface 12-lead electrocardiogram (ECG) is widely available, fast, inexpensive, and safe. However, its value to predict a true myocardial scar in patients with ischemic cardiomyopathy (ICM) has not been studied extensively yet.
Giannopoulos, Andreas A +23 more
core +1 more source
Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam +3 more
wiley +1 more source
MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann +7 more
wiley +1 more source
Dioscin Promotes Ferroptosis in Cervical Cancer Cells via the TIGAR‐ROS Axis
Cancer Science, EarlyView.Dioscin suppresses cervical cancer progression by promoting ferroptosis. Mechanistically, Dioscin binds to TIGAR and inhibits TIGAR function, elevating ROS levels and inducing ferroptosis. ABSTRACT Cervical cancer seriously threatens women's life and health, highlighting the urgent need for targeted therapies.
Yameng Liu +6 more
wiley +1 more source
Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs
Clinical Endocrinology, EarlyView.ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams +3 more
wiley +1 more source
Liver Organoids: From Disease Modelling to Regenerative Medicine
Cell Proliferation, EarlyView.Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang +5 more
wiley +1 more source
Gadolinium-Free Cardiac MRI Myocardial Scar Detection by 4D Convolution Factorization. [PDF]
Med Image Comput Comput Assist Interv, 2023 Amyar A +8 more
europepmc +1 more source
, 2005 We sought to determine the relative impact of myocardial scar and viability on post-infarct left ventricular (LV) remodeling in medically-treated patients with LV dysfunction.
Chan, J. +3 more
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