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Heart Failure Reviews, 2003
Myocardial stunning refers to the contractile dysfunction that occurs following an episode of acute ischaemia, despite the return of normal blood flow. The phenomenon was initially identified in animal models, where it has been very well characterised, and there was initial doubt about whether a similar syndrome occurred in humans, and if it did ...
Edward, Barnes, Masood A, Khan
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Myocardial stunning refers to the contractile dysfunction that occurs following an episode of acute ischaemia, despite the return of normal blood flow. The phenomenon was initially identified in animal models, where it has been very well characterised, and there was initial doubt about whether a similar syndrome occurred in humans, and if it did ...
Edward, Barnes, Masood A, Khan
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Therapy for myocardial stunning
Basic Research in Cardiology, 1995Myocardial stunning, or postischemic dysfunction, is defined as delayed recovery of systolic and/or diastolic function of viable myocardium despite restoration of coronary flow after an ischemic insult (4). The severity and duration of myocardial stunning is highly dependent on the duration and severity of the previous ischemic insult (2).
Y, Birnbaum, R A, Kloner
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Ubiquity of myocardial stunning
Basic Research in Cardiology, 1995The prolonged depression of myocardial function following episodes of myocardial ischemia now known as myocardial stunning, appears ubiquitous in both the experimental and clinical settings. With recent therapies designed to ameliorate ischemic myocardium, e.g., coronary artery bypass, coronary thrombolysis, coronary angioplasty, the inexorable ...
S F, Vatner, G R, Heyndrickx
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Clinical manifestations of myocardial stunning
Coronary Artery Disease, 2001The phenomenon of myocardial stunning has been observed in all animal species studied. The possible occurrence of myocardial stunning in man has been demonstrated after either regional ischemia (such as exercise-induced angina, vasospastic or unstable angina) or after global ischemia (i.e., after cardioplegic arrest during cardiac surgery, or cardiac ...
AMBROSIO, Giuseppe, TRITTO, Isabella
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A flow-limiting stenosis is the major determinant of exercise-induced myocardial stunning in patients with coronary artery disease [PDF]
Journal of Cardiology, 2010 SummaryBackgroundAlthough stress-induced myocardial stunning often develops after exercise testing, determinants of this phenomenon have not been evaluated.Methods and resultsThirty-one patients with 1-vessel coronary artery disease, limited to the left ...
Nobuhiro Tanaka +2 more
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Clinical relevance of myocardial ?stunning?
Cardiovascular Drugs and Therapy, 1991Experimental studies have demonstrated that myocardium reperfused after reversible ischemia exhibits prolonged depression of contractile function ("stunning"). Despite the multiplicity of clinical situations in which myocardial stunning would be expected to occur, investigation of this phenomenon in humans has been hindered by several major problems ...
R, Bolli, C J, Hartley, R S, Rabinovitz
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Journal of Cardiac Surgery, 1993
The use of animal models is a valuable approach to the elucidation of the pathophysiology of myocardial stunning. Coronary occlusion followed by reperfusion produces stunning experimentally, mimicking a myocardial infarction followed by thrombolysis, angioplasty, or coronary bypass.
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The use of animal models is a valuable approach to the elucidation of the pathophysiology of myocardial stunning. Coronary occlusion followed by reperfusion produces stunning experimentally, mimicking a myocardial infarction followed by thrombolysis, angioplasty, or coronary bypass.
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Myocardial Stunning: An Overview
Journal of Cardiac Surgery, 1993Over the past two decades, we have challenged the belief that transient ischemia is benign with little functional sequelae following resolution of ischemia. The phenomenon of prolonged postischemic contractile dysfunction, or of myocardial stunning, has been developed and is under investigation using multiple experimental and clinical models ...
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Therapy of myocardial stunning
Basic Research in Cardiology, 1997Since in the clinical setting stunning may coexist with persistently ischemic and infarcting myocardium, the ben fit el therapeutic interventions on the stunned myocardium must be weighed against potential deleterious effects on the ischemic myocardium.
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Independency of myocardial stunning of endothelial stunning?
Basic Research in Cardiology, 2007Vascular endothelial cells play an important role in the control of vascular tone. The reasons for coronary endothelial dysfunction are complex and may involve ischemia/reperfusion injury. We investigated whether endothelial, smooth muscle, and myocardial dysfunction are independent phenomena.Rabbit hearts were rapidly excised without intermittent ...
Solange C, Garcia +4 more
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