Results 141 to 150 of about 11,293,345 (337)

Prognostic implications of left ventricular myocardial work indices in cardiac amyloidosis [PDF]

, 2020
Tor Skibsted Clemmensen, Hans Eiskjær, Bertil Ladefoged, Fabian Mikkelsen, Jens Sørensen, Sven-Olof Granstam, Sara Rosengren, Frank A. Flachskampf, Steen Hvitfeldt Poulsen   +8 more
openalex   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

P1774 Myocardial work indices in adult patients with repaired aortic coartation [PDF]

, 2020
Ana Teresa Timóteo, Luísa Moura Branco, A Galrinho, Rita Ilhão Moreira, Lídia de Sousa, Ana Agapito, Rui Cruz Ferreira   +6 more
openalex   +1 more source

METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

Advanced Science, EarlyView.
METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang, Shuirong Lin, Yutong Zhao, Jiale Chen, Linyuan Huang, Yuyao Liu, Zixin Huang, Dongxin An, Yifan Zhang, Zimin Song, Xi Yu, Yunpeng Hua, Jing Wang, Weiwei Wang, Yu Guo, Ming Kuang, Fang Wang, Shuibin Lin, Shunli Shen   +18 more
wiley   +1 more source

Myocardial Work Assessment for the Prediction of Prognosis in Advanced Heart Failure

, 2021
Felix Hedwig, Olena Nemchyna, Julia Stein, Christoph Knosalla, Nicolas Merke, Fabian Knebel, Andreas Hagendorff, Felix Schoenrath, Volkmar Falk, Jan Knierim   +9 more
openalex   +1 more source

155 Myocardial work in hypertension and mitral regurgitation- insights from non-invasive assessment of left ventricular pressure-strain relations [PDF]

, 2020
Filip Lončarić, M Marciniak, L Nunno, João Filipe Fernandes, M Mimbrero, Laia Tirapu, Dora Fabijanović, Laura Sanchís, A Doltra, Maja Čikeš, Pablo Lamata, Bart Bijnens, Marta Sitges   +12 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Acute responses to low-intensity aerobic exercise with continuous and intermittent blood flow restriction

Frontiers in Sports and Active Living
IntroductionThis study examined muscular and cardiovascular responses to light-intensity aerobic exercise with different blood flow restriction (BFR) protocols.MethodsTen males performed four protocols on the cycle ergometer: low-intensity exercise with ...
James Brown, Jakob D. Lauver, Jakob D. Lauver, Timothy R. Rotarius, Justin P. Guilkey   +4 more
doaj   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

The emerging role of echocardiography-based techniques in cardio-onco-hematology

Frontiers in Oncology
In decades, the overall survival rate for cancer patients has improved significantly with continuous advances in cancer treatment technologies. However, cancer therapeutics-related cardiac dysfunction (CTRCD) has been one of the most worrying side ...
Yichan Zhang, Mingxing Xie, Mingxing Xie, Mingxing Xie, Jing Wang, Jing Wang, Jing Wang, Bo Zhang   +7 more
doaj   +1 more source