Results 281 to 290 of about 11,460,446 (385)

12‐HETE Is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, EarlyView.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Right Ventricular Myocardial Work Predicts Pulmonary Capillary Wedge Pressure Rise During Exercise in Heart Failure. [PDF]

JACC Adv
Huang KC, Lin TT, Lin LC, Lin LY, Wu CK.
europepmc   +1 more source

Reinstating Niche Failure in Diabetic Cranial Defects via Chronotaxic Signal‐Amplifying Fluidic Biomimetic Hydrogel

Advanced Science, EarlyView.
An in situ moldable GelSSO/PDA@SDF hydrogel functions as a chronotaxic signal‐amplifying biomimetic niche to restore regenerative failure in diabetic cranial defects. By sequentially releasing SDF‐1α‐loaded PDA nanoparticles and osteoinductive oligodeoxynucleotides, it orchestrates immunomodulation, progenitor recruitment, angiogenesis, and ...
Yingji Mao, Yu Chen, Runlin Fan, Pengzhen Zhuang, Hongbo Zhang, Pinghui Zhou   +5 more
wiley   +1 more source

Study of the rehabilitation, prognosis and capacity to resume work of patients with myocardial infarction. Comparison of 4-week and 8-week rehabilitation programs.

, 1983
Yoshinori Fujita, Takeshi Hasegawa, Hirokazu Niitani   +2 more
openalex   +2 more sources

Non-Invasive Myocardial Work Identifies Patients with Obstructive Coronary Lesions After Orthotopic Heart Transplantation. [PDF]

Diagnostics (Basel)
Manrique Antón R, Pascual Izco M, Bastarrika G, Díaz Dorronsoro A, Ezponda A, de la Torre Carazo F, Salteráin N, Jimeno-San Martín L, Martín-Calvo N, Iribarren MJ, Rábago G.   +10 more
europepmc   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, EarlyView.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Assessment of myocardial work in sarcomere gene mutation carriers, healthy controls and overt nonobstructive hypertrophic cardiomyopathy. [PDF]

Echo Res Pract
Pires CM, Joy G, Triantafyllou M, Monteiro RP, Ferreira A, Savvatis K, Lopes LR.   +6 more
europepmc   +2 more sources

Systemic Vascular Resistance and Myocardial Work Analysis in Hypertrophic Cardiomyopathy and Transthyretin Cardiac Amyloidosis with Preserved Left Ventricular Ejection Fraction

Cesare de Gregorio, Giancarlo Trimarchi, Denise Cristiana Faro, Cristina Poleggi, Lucio Teresi, Fabrizio De Gaetano, Concetta Zito, Francesca Lofrumento, Ioanna Koniari, Roberto Licordari, Nicholas G. Kounis, Ines Monte, Gianluca Di Bella   +12 more
openalex   +2 more sources

The impact of hypercortisolism beyond metabolic syndrome on left ventricular performance: a myocardial work analysis. [PDF]

Cardiovasc Diabetol
Sahiti F, Detomas M, Cejka V, Hoffmann K, Gelbrich G, Frantz S, Kroiss M, Heuschmann PU, Hahner S, Fassnacht M, Deutschbein T, Störk S, Morbach C.   +12 more
europepmc   +1 more source