Results 91 to 100 of about 78,026 (273)
How to formulate membrane potential in a spatially homogeneous myocyte model? [PDF]
arXiv, 2005 Membrane potential in a mathematical model of a cardiac myocyte can be formulated in different ways. Assuming a spatially homogeneous myocyte that is strictly charge-conservative and electroneutral as a whole, two methods will be compared: (1) the differential formulation dV/dt=-I/C_m of membrane potential used traditionally; and (2) the capacitor ...
arxiv
An In-Silico Study on Integrated Mechanisms of Mechano-Electric Coupling in Ischaemic Arrhythmogenesis [PDF]
arXiv, 2023 Heterogeneous mechanical dyskinesis during acute myocardial ischaemia is thought to contribute to arrhythmogenic alterations to cardiac electrophysiology. Various forms of mechano-electric coupling (MEC) mechanisms have been suggested to contribute to these changes, with two primary mechanisms being: (1) myofilament-dependent calcium release events ...
arxiv
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Ryanodine receptor type 2 (RYR2) is a large calcium channel that has been identified as one of the most frequently mutated genes in lung adenocarcinoma (LUAD). Despite its potential significance, the role of RYR2 in LUAD remains poorly understood.
Tao Wang +3 more
wiley +1 more source
The contribution of extracellular RNA and its derived biomaterials in disease management
BMEMat, EarlyView.The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei +8 more
wiley +1 more source
Generation and escape of local waves from the boundary of uncoupled cardiac tissue [PDF]
, 2007 We aim to understand the formation of abnormal waves of activity from myocardial regions with diminished cell-to-cell coupling. In route to this goal, we studied the behavior of a heterogeneous myocyte network in which a sharp coupling gradient was placed under conditions of increasing network automaticity.
arxiv +1 more source
Fueling cardiac myocyte proliferation
The Journal of Cardiovascular Aging[Image: see text]
Manisha Deogharia, Priyatansh Gurha
openaire +2 more sources
BMEMat, EarlyView.Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu +9 more
wiley +1 more source
Journal of Pharmacological Sciences, 2008 It has been suggested that a new type of large-conductance Ca2+-activated K+ (BK) channel is distributed in the inner mitochondrial membrane (mitoKCa channel) and that its opening may attenuate ischemic cardiac injury.
Kazuho Sakamoto +3 more
doaj
Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart
Frontiers in Cardiovascular Medicine, 2020 The integrity of the proteome in cardiac myocytes is critical for robust heart function. Proteome integrity in all cells is managed by protein homeostasis or proteostasis, which encompasses processes that maintain the balance of protein synthesis ...
Adrian Arrieta +3 more
doaj +1 more source
Segmentation of histological images and fibrosis identification with a convolutional neural network [PDF]
, 2018 Segmentation of histological images is one of the most crucial tasks for many biomedical analyses including quantification of certain tissue type. However, challenges are posed by high variability and complexity of structural features in such images, in addition to imaging artifacts.
arxiv +1 more source