Results 91 to 100 of about 141,107 (310)

Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells

BMC Genomics, 2012
Background We have shown previously that pan-HDAC inhibitors (HDACIs) m-carboxycinnamic acid bis-hydroxamide (CBHA) and trichostatin A (TSA) attenuated cardiac hypertrophy in BALB/c mice by inducing hyper-acetylation of cardiac chromatin that was ...
Majumdar Gipsy, Adris Piyatilake, Bhargava Neha, Chen Hao, Raghow Rajendra   +4 more
doaj   +1 more source

A pseudo active kinematic constraint for a biological living soft tissue: an effect of the collagen network [PDF]

, 2008
Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber direction. We suggested
Bourdarias, Christian, Gerbi, Stéphane, Ohayon, Jacques   +2 more
core   +5 more sources

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

Functional role of t-tubules on calcium transients in canine cardiac myocytes

Heart and Mind, 2019
Background: A loss of t-tubules and alterations in ultrastructure occur in cultured ventricular myocytes. A similar alteration in t-tubules and ultrastructure is well documented under certain pathological conditions such as heart failure. We examined the
Alicia A Barnes, Zachary E Williams, Samuel Olzcyk, Alida Cooke, Jonathan A Cordeiro, Tanya Zeina, Rueben Mathew, Jacqueline A Treat, Gary L Aistrup, Jonathan M Cordeiro   +9 more
doaj   +1 more source

IL-1α and TNF-α Down-Regulate CRH Receptor-2 mRNA Expression in the Mouse Heart [PDF]

, 2001
Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II.
Coste, Sarah C., Heldwein, Kurt A., Stenzel-Poore, Mary P., Stevens, Susan L., Tobar-Dupres, Eric   +4 more
core   +2 more sources

Progression and prognostic significance of electrocardiographic findings in patients with cardiac amyloidosis

ESC Heart Failure, Volume 12, Issue 2, Page 809-818, April 2025.
Abstract Aims This study aimed to evaluate the change of the main electrocardiographic (ECG) characteristics and their prognostic role across the main subtypes of cardiac amyloidosis [light‐chain amyloidosis (AL) and hereditary (ATTRv) and wild‐type transthyretin amyloidosis (ATTRwt)].
Alessia Argirò, Mattia Zampieri, Carlotta Mazzoni, Carlo Fumagalli, Michela Baccini, Alessandra Mattei, Alberto Cipriani, Laura De Michieli, Aldostefano Porcari, Gianfranco Sinagra, Marco Merlo, Giacomo Tini, Beatrice Musumeci, Domitilla Russo, Pier Filippo Vianello, Marco Canepa, Roberto Licordari, Gianluca di Bella, Claudio Rapezzi, Federico Perfetto, Francesco Cappelli   +20 more
wiley   +1 more source

Increased sarcolemmal Na+/H+ exchange activity in hypertrophied myocytes from dogs with chronic atrioventricular block

Frontiers in Physiology, 2013
Dogs with compensated biventricular hypertrophy due to chronic atrioventricular block (cAVB), are more susceptible to develop drug-induced Torsade-de-Pointes arrhythmias and sudden cardiac death.
Marcel evan Borren, Marc eVos, Marien eHoutman, Gudrun eAntoons, Jan Hindrik Ravesloot   +4 more
doaj   +1 more source

PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes. [PDF]

PLoS ONE, 2011
Phosphoinositide 3-kinases (PI3Ks) regulate numerous physiological processes including some aspects of cardiac function. Although regulation of cardiac contraction by individual PI3K isoforms has been studied, little is known about the cardiac ...
Chia-Yen C Wu, Zhiheng Jia, Wei Wang, Lisa M Ballou, Ya-Ping Jiang, Biyi Chen, Richard T Mathias, Ira S Cohen, Long-Sheng Song, Emilia Entcheva, Richard Z Lin   +10 more
doaj   +1 more source

Biochemical and immunochemical analysis of the arrangement of connexin43 in rat heart gap junction membranes [PDF]

, 1990
A 43 × 10^3 M_r protein (designated connexin43 or Cx43) is a major constituent of heart gap junctions. The understanding of its arrangement in junctional membranes has been extended by means of site-directed antibodies raised against synthetic peptides ...
Laird, D. W., Revel, J.-P.
core  

Cell-based gene therapy for mending infarcted hearts [PDF]

, 2011
The goal of this study was to analyse the efficiency of a combinatorial cell/growth factor therapy to improve function of infarcted murine hearts. The Insulin-like Growth Factor-1 (IGF-1) isoform, IGF-1Ea, has been shown to reduce scar formation and ...
Poudel, Bhawana, Poudel, Bhawana
core   +1 more source